Valsartan in combination with metformin and gliclazide in diabetic rat model using developed RP-HPLC method

Abstract

Background Oral administration of biguanides (metformin) and sulfonylureas (gliclazide) are the most common approach of management of type 2 diabetes in humans. Among these diabetic patients, approximately 40–60% suffers from hypertension. Hence, the need of the day is application of polytherapy. A major challenge in polytherapy is the drug-drug interactions that may arise. Hence, this study is focused to develop a reverse phase high-performance liquid chromatography (RP-HPLC) method for concurrent estimation of diabetic drug metformin and hypertension drug valsartan using C18 column and find any possible pharmacokinetic interactions between the two drug combinations strategies, i.e., metformin-valsartan and gliclazide-valsartan in streptozotocin-induced diabetic rats. Result The bioanalysis of drug-drug interaction pharmacokinetic result showed no significant difference in the tmax of single treatment of gliclazide and single treatment of metformin or upon co-administration with valsartan. Conclusion Our study has shown that polytherapy of valsartan, a drug administered for hypertension along with hypoglycemic drugs metformin and gliclazide, can be advantageous and safe in patients suffering from both diabetes and hypertension.

[Retracted] Effects of Valsartan on LN, FN, MDA, Renal Tissue Fibrosis, and Inflammatory Infiltration in DN Rats

“…The MEK-specific inhibitor U0126 can inhibit the MEK/ERK pathway and thus inhibit the migration of cavity squamous cell carcinoma [ 16 ]. Nrf1, as a mitochondrial function gene, can regulate antioxidant genes, proteasome genes, and other transcription genes, so as to play an antioxidative stress role and protect cells from oxidative stress [ 17 ]. This examination found that, in contrast with the normal set, the protein standards of MEK and p-ERK in the model set are subjoined, and the standard of Nrf1 protein is lessened ( p < 0.05).…”

Characterization And Compatibility Studies Of Valsartan With Pharmaceutical Excipients

“…The surface morphology of the raw materials and of the binary systems was examined by means of Hitachi SEM (Tokyo Japan). The powders were precisely fixed on an aluminium stub using double-sided adhesive 16910 tape and then were made electrically conductive by coating in a vaccum with a thin layer of gold for 30 seconds and at 30 W [14].…”