Variação dos parâmetros físicos do campo ultra-sônico em fonoforese com diclofenaco gel

Abstract

I The objective of the present work was of analyzing, experimentally, the variation of the transmission index and the coefficient of ultrasonic reduction in the half diclofenaco gel, as well as, the penetration of the drug in samples of similar jelly the human skin through the phonophoresis. The variation of these parameters was investigated in 120 agar-agar samples, (continuous way, 1MHz of frequency, in the intensities of 1,0 and 1,5 W/cm²), for 5 minutes. The proof bodies form divided in referring groups the ultrasound intensities used, and each one of these groups, it was subdivided in subgroups corresponding to the different means used for irradiation. The investigation of the ultrasonic transmission was measured starting from a ULTRASONIC POWER to PUT, I model UPM-DT 10. The calculate it of the reduction coefficient was accomplished starting from the data of reading of the ultrasonic transmission. The penetration or not of the drug it was studied for it analyzes macroscopic and microscopic. According to the obtained results there was not significant variation in the transmission indexes and in the coefficients of reduction of the diclofenaco gel in comparison with the neutral gel. The penetration of the medicine went of 3 mm to the samples irradiated with the intensity of 1,0W/cm² and of 5 mm for the samples irradiated with 1,5W/cm², there was not evidences of penetration of the drug in the group control. The results obtained in this study suggest that the phonophoresis of the diclofenaco gel is effective in the intensities 1,0 and 1,5 W/cm².

Concentração plasmática de diclofenaco sódico em cães, submetidos à fonoforese

“…A baixa intensidade e o modo pulsado, utilizados nesta pesquisa, são as características do equipamento desenvolvido, o qual tem sido empregado em investigações experimentais e clínicas por Xavier e Duarte (1983) e Rubin et al (2001). A quantidade de 2g de diclofenaco sódico aplicada, nos grupos sem o gel comum para ultrassonografia, foi suficiente para a realização da sessão, evitando que o cabeçote do ultrassom ficasse sem o meio de acoplamento, segundo recomenda Starkey (2001 Carnio (2005), em avaliação da fonoforese com diclofenaco sódico em gelatina imitando pele humana, verificou que a penetração do medicamento foi de 3mm para a irradiação com 1,0Wcm…”

Ex vivo study of use of physiotherapy ultrasound in polymethylmethacrylate beads doped with methylene blue as an antibiotic carrier

“…Firstly, the silicone (Siloc ® , ITW Polymers, São Paulo, Brazil) mold was developed by using a Petri dish (23-cm diameter) as mold base; its inner surface was coated with petroleum jelly to avoid adhesion (2,(13)(14)(15). Silicone was spread onto a Petri dish, and 50 synthetic beads (0.6-mm diameter) embedded in petroleum jelly were distributed in two dish, 25 beads in two Petri dish in total (Figure 1 and 2).…”

“…Subsequently, the other part of the mold remained there until final polymerization, which took approximately 10 min. Finally, PMMA beads (0.6 mm diameter) doped with methylene blue were removed from the silicone mold (2,15) .…”

“…The beaker was placed on magnetic stirrer (75° C to 85° C) until getting a homogenous and transparent mix. The mix was distributed into five plastic vials (180 mL) and left to jellify at room temperature (22º C) (15) .…”

“…Eight (8) specimens comprised the control group, which was not irradiated with ultrasound. The control group was added to the experiment in order to check the incidence (or not) of passive methylene blue dispersion from doped beads in the gelling agent (15) .…”