Variation in fetal ultrasound biometry based on differences in fetal ethnicity

Ogasawara, Keith K.

doi:10.1016/j.ajog.2009.02.031

Cited by 15 publications

(11 citation statements)

References 20 publications

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“…Undoubtedly, ethnic differences in fetal femur and humerus diaphysis length would have a considerable impact on Down syndrome screening; in one study, positive sonographic results were reported more frequently in nonwhite ethnicities because of shorter long bones 2 . In our previous study, we obtained normal ranges for the fetal nasal bone during the second trimester of pregnancy 4 .…”

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confidence: 89%

Normal Ranges for Fetal Femur and Humerus Diaphysis Length During the Second Trimester in an Iranian Population

Tahmasebpour¹,

Pirjani²,

Rahimiforoushani³

et al. 2012

Journal of Ultrasound in Medicine

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onographic markers are widely used for aneuploidy screening. Shortening of the fetal long bones such as the humerus and femur is a sonographic soft marker for screening of Down syndrome in the second trimester. Ethnic differences in fetal biometric measurements have been documented. [1][2][3] Beigi and ZarrinKoub 3 reported that Iranian fetuses had a shorter femur length in comparison with western studies. Kovac et al 1 concluded that Asian groups had a less-than-expected femur length.Undoubtedly, ethnic differences in fetal femur and humerus diaphysis length would have a considerable impact on Down syndrome screening; in one study, positive sonographic results were reported more frequently in nonwhite ethnicities because of shorter long bones. 2 In our previous study, we obtained normal ranges for the fetal nasal bone during the second trimester of pregnancy. 4 The aim of this study was to provide normal ranges for femur and humerus diaphysis length during the second trimester in an Iranian population. -Reza Tahmasebpour, MD, Reihaneh Pirjani, MD, Abbas Rahimi-Foroushani, PhD, Saeed Reza Ghaffari, MD, Fatemeh Rahimi-Sharbaf, MD, Farzaneh Fattahi Masrour, MD Received November 18, 2011, from the Iranian Fetal Medicine Foundation, Tehran, Iran (A.-R.T., S.R.G., F.F.M.) Ahmad ORIGINAL RESEARCHObjectives-Shortening of the fetal long bones is a sonographic soft marker for screening of Down syndrome in the second trimester that can be influenced by ethnicity. The purpose of this study was to provide normal reference ranges for femur and humerus diaphysis length during the second trimester of pregnancy in an Iranian population.Methods-This cross-sectional study was performed on 3011 singleton fetuses at 15 to 28 weeks' menstrual age. The relationship between menstrual age and both femur and humerus diaphysis length was determined, and percentile values for each menstrual week were provided.Results-The median femur diaphysis length ranged from 18.05 mm at 15 menstrual weeks to 52.20 mm at 28 menstrual weeks, and the mean humerus diaphysis length ranged from 17.65 mm at 15 menstrual weeks to 48.10 mm at 28 menstrual weeks. There was a linear relationship between menstrual age and both femur diaphysis length (R 2 = 0.957) and humerus diaphysis length (R 2 = 0.941).Conclusions-We have provided normal reference ranges for femur and humerus diaphysis length during the second trimester of pregnancy in an Iranian population.

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confidence: 89%

Normal Ranges for Fetal Femur and Humerus Diaphysis Length During the Second Trimester in an Iranian Population

Tahmasebpour¹,

Pirjani²,

Rahimiforoushani³

et al. 2012

Journal of Ultrasound in Medicine

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“…Some studies have suggested that maternal ethnicity may influence long bone length, although Weisz et al found no evidence of ethnic differences. In this study, we did not consider maternal ethnicity, which may represent a limitation.…”

Section: Discussionmentioning

confidence: 99%

Association of midtrimester short femur and short humerus with fetal growth restriction

Carvalho

Figueiredo

et al. 2012

Prenatal Diagnosis

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“…It has been shown that the choice of reference charts for fetal size has a substantial impact on the quality of fetal biometric assessments 12 . There is also a rising concern that fetal charts developed in Europe or North America might not be appropriate for use in populations with different ethnic backgrounds, such as those from Latin America, because ethnicity has a considerable influence on fetal biometry 13 – 17 …”

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confidence: 99%

“…12 There is also a rising concern that fetal charts developed in Europe or North America might not be appropriate for use in populations with different ethnic backgrounds, such as those from Latin America, because ethnicity has a considerable influence on fetal biometry. [13][14][15][16][17] In addition, reports on comparative results of fetal size charts from different populations versus the most widely used charts [1][2][3][4][5][6][7][8][9]18 have shown differences in the percentile curves for the biparietal diameter, head circumference, abdominal circumference, and femur length, with some differences being more important than others. These differences can be due to variations in the methods used for measurement of the different fetal structures, selection criteria, statistical methods, and ethnicity variability; therefore, most of the authors who have made these comparisons have proposed the use of their local tables for fetal biometric assessments in their respective populations.…”

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confidence: 99%