2008
DOI: 10.1158/1541-7786.mcr-07-0366
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Vascular Endothelial Growth Factor Stimulates Organ-Specific Host Matrix Metalloproteinase-9 Expression and Ovarian Cancer Invasion

Abstract: Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP) regulate each other, contributing to tumor progression. We have previously reported that MMP9 induces the release of tumor VEGF, promoting ascites formation in human ovarian carcinoma xenografts. The aim of this study was to investigate whether tumor-derived VEGF regulated the expression of gelatinase by the stroma, influencing the invasive properties of ovarian tumors. Tumor variants derived from 1A9 human ovarian carcinoma, stably … Show more

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Cited by 66 publications
(49 citation statements)
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“…Recently, cross-talk between VEGF and MMP-9 has been suggested to play a role in ovarian carcinoma invasion and metastasis. [37][38][39][40] Host cells, specifically inflammatory cells as opposed to tumor cells, have been implicated as being the primary source of MMP-9 in these models. 37 Previous studies have determined that VEGF-mediated inflammation plays a critical role in the pathological angiogenesis induced by it.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Recently, cross-talk between VEGF and MMP-9 has been suggested to play a role in ovarian carcinoma invasion and metastasis. [37][38][39][40] Host cells, specifically inflammatory cells as opposed to tumor cells, have been implicated as being the primary source of MMP-9 in these models. 37 Previous studies have determined that VEGF-mediated inflammation plays a critical role in the pathological angiogenesis induced by it.…”
Section: Discussionmentioning
confidence: 99%
“…[37][38][39][40] Host cells, specifically inflammatory cells as opposed to tumor cells, have been implicated as being the primary source of MMP-9 in these models. 37 Previous studies have determined that VEGF-mediated inflammation plays a critical role in the pathological angiogenesis induced by it. [41][42][43] Our results suggest that both VEGF and active MMPs recruit CD11bϩ inflammatory cells to the corneal stroma, which are likely to play a critical role in the angiogenic response.…”
Section: Discussionmentioning
confidence: 99%
“…The anti-VEGF antibody inhibits both MMP-9 expression and tumor invasion into the ovaries. 48 In contrast, VEGF is released from extracellular stores by MMP-9, an event that increases the bioavailability of the angiogenic mitogen. 49 Furthermore, the implication of VEGFR-1 in MMP-9 expression in lung cancer was revealed.…”
Section: Hypoxia and Af Remodelingmentioning
confidence: 99%
“…Vascular endothelial growth factor (VEGF) and angiogenesis are important promoter of ovarian cancer progression 25,26 . Both co-relate directly with the extent of disease and inversely with progression free survival 27,28 and overall survival 29,30,31 often in dependently of known prognostic factors 32,33 .…”
Section: Casementioning
confidence: 99%