Vascular endothelial growth factor (VEGF) stimulates monocyte migration through endothelial monolayers via increased integrin expression

Heil, Matthias; Clauss, Matthias; Suzuki, Keisuke; Buschmann, Ivo; Willuweit, Antje; Fischer, Svaantje; Schäper, Wolfgang

doi:10.1078/0171-9335-00113

Cited by 113 publications

(79 citation statements)

References 51 publications

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“…Although they may be a source of endothelial or other progenitor cells, they probably act principally through paracrine mechanisms. 1,2 BMDCs are currently being used to treat ischemic conditions in clinical trials. [3][4][5] However, given our rudimentary knowledge of how BMDCs act as agents of vascular growth and tissue repair, it is not surprising that results of clinical trials to date are mixed.…”

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confidence: 99%

Lin− Cells Mediate Tissue Repair by Regulating MCP-1/CCL-2

Schatteman

Awad

Nau

et al. 2010

The American Journal of Pathology

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Exogenous bone marrow-derived cells (BMDCs) are promising therapeutic agents for the treatment of tissue ischemia and traumatic injury. However , until we identify the molecular mechanisms that underlie their actions , there can be no rational basis for the design of therapeutic strategies using BMDCs. The pro-healing effects of BMDCs are apparent very shortly after treatment , which suggests that they may exert their effects by the modulation of acute inflammation. We investigated this hypothesis by taking advantage of the fact that BMDCs from healthy , young, but not obese , diabetic mice stimulate vascular growth. By comparing both in vitro secretion and in vivo local induction of acute phase inflammatory cytokines by these cells , we identified monocyte chemoattractant factor 1 and tumor necrosis factor ␣ as potential mediators of BMDC-induced tissue repair. In vivo analysis of BMDC-treated ischemic limbs and cutaneous wounds revealed that the production of monocyte chemoattractant factor 1 by exogenous and endogenous BMDCs is essential for BMDC-mediated vascular growth and tissue healing , while the inability of BMDCs to produce tumor necrosis factor ␣ appears to play a lesser but still meaningful role. Thus, measurements of the secretion of cytokines by BMDCs may allow us to identify a priori individuals who would or would not be good candidates for BMDC-based therapies.

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mentioning

confidence: 99%

Lin− Cells Mediate Tissue Repair by Regulating MCP-1/CCL-2

Schatteman

Awad

Nau

et al. 2010

The American Journal of Pathology

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“…It is well known that neoangiogenesis is directly related to tumor hypoxia [16], leading to the secretion of VEGF fibroblasts with chemoatractism for macrophages and triggering the process of neoangiogenesis [17]. Moreover, hypoxia causes activation of fibroblasts by transforming them into myofibroblasts that secrete SDF1 and VEGF.…”

Section: Discussionmentioning

confidence: 99%

Neoangiogenesis. Assessment in Esophageal Adenocarcinomas

2014

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Esophageal cancer has always been subject of research for various studies. According to some authors, esophageal cancer represents the 10th leading cause of cancer in the world with a 5-year survival of 10 %. In terms of anatomopathological form of the esophageal neoplasia, the literature mainly describes two major pathological types: adenocarcinoma and esophageal squamous cell carcinoma. Lately there has been an increased incidence of esophageal adenocarcinoma. The aim of the present work was to study neoangiogenesis in esophageal adenocarcinomas. The study was conducted on 40 cases diagnosed and surgically treated. Subsequently, fragment processing was performed using various immunohistochemical staining and marking with CD34 and p53 antigen. Later, quantitative measurements were performed, and images were taken using a microscope imaging system. In the end of the procedures, the professional program PRODIT 5.2. was applied. The study of the vascular system in the esophageal epithelial tumors revealed an axis consisting of three elements which have a mutual induction process: inflammatory infiltrate-neoangiogenesis-fibrosis, with significant differences between the three degrees of differentiation. A significant increase in tumor micro vascular density was present together with the increasing of the histological grading, with an inverse correlation with the degree of differentiation and directly proportional to the risk of malignancy.

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“…Aus diesem Grund ist es ein wichtiges therapeutisches Ziel, nach Möglichkeiten zu suchen, das Wachstum von Kollateralarterien zu stimulieren und damit diesen natürlichen Prozess zu opti mieren. Die klinische Anwendung von be kannten Wachstumsfaktoren wie "mono cyte chemoattractant protein1" (MCP1) [6], "vascular endothelial growth factor" (VEGF) [1,2,5], "basic fibroblast growth factor" (bFGF), "fibroblast growth factor 2" oder 4 (FGF2, FGF4) werden jedoch kontrovers diskutiert [10,13].…”

Section: Stimulierung Des Wachstums Peripherer Und Zerebraler Kollateunclassified