Vascular Risks and Complications in Diabetes Mellitus: The Role of Helicobacter Pylori Infection

The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

“…Besides, it has been reported that SAA inhibits lecithin-cholesterol acyltransferase activity, and both mechanisms can reduce the concentrations of HDL-C (1). Our results are in agreement with the studies which have observed no significant difference in HDL-C and apo A-I levels between HP seropositive and seronegative subjects (2,5,10,18).…”

“…It is thought that HP induced inflammation can be a trigger to the production of high levels of IL-6 and TNF-a. It is known that IL-6 can increase hepatic gluconeogenesis and TG synthesis and TNF-a inhibits lipoprotein lipase activity and stimulates he patic lipogenesis, leading to lipid mobilisation from ti ssues and to elevated serum TG and lowered HDL-C concentrations (1,10,14). The pathogenic mechanisms underlying the increase in TC and LDL-C levels in HP seropositive subjects are still unclear.…”

“…Helicobacter pylori (HP) is a gram-negative microaerophilic spiral bacterium which causes one of the most prevalent infections in the world, affecting approximately 50% of the world's population (10). HP occurs naturally and inhabits the mucous layer that covers the gastric epithelial cells.…”

“…Although most authors reported about an association between HP infection and a proatherogenic lipid profile (6,(16)(17)(18)(19) which was normalized after successful eradication of HP (4,20), few studies did not confirm these results (1,2,5,10,21). Therefore, the influence of chronic HP infection on lipid parameter changes and their implication in atherogenic mechanisms of this infection are still unclear.…”

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

“…Some studies have shown a higher prevalence of H.pylori infection in people with type 1 (de Luis et al, 1998; El-Eshmawy et al, 2011) and type 2 diabetes (Bener et al, 2007;Devrajani et al, 2010). This relationship seems to be correlated with gender (Hamed et al, 2008), BMI (Bener et al, 2007;Perdichizzi et al, 1996), the duration of diabetes (de Luis et al, 1998), the presence of dyspepsia, cardiovascular autonomic neuropathy (Gulcelik et al, 2005) and glycated hemoglobin (Chen and Blaser, 2012;Hsieh et al, 2013), whilst other studies have indicated neutral or even negative results (Anastasios et al, 2002;Demir et al, 2008;Gillum, 2004). These contradictory findings might well be due to the different study populations.…”