Vasculitis as Temporally Associated With COVID-19 Infection or Vaccination: A Single-center Experience

Hočevar, Alojzija; Simonović, Zoran; Rotar, Žiga; Tomšič, Matija

doi:10.3899/jrheum.210788

Cited by 13 publications

(18 citation statements)

References 7 publications

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“…It has been observed after the Pfizer-BioNTech mRNA vaccine (BNT16B2b2) ( 57 – 65 ). Moderna mRNA vaccine (mRNA-1273) ( 66 – 68 ). Oxford-AstraZeneca adenoviral vaccine (ChAdOx1 nCoV-19 AZD1222) ( 69 – 79 ).…”

Section: Anti-sars-cov-2 Vaccination-induced Cutaneous Vasculitismentioning

confidence: 99%

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Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic

et al. 2022

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Cutaneous vasculitides encompass a heterogeneous group of clinicopathological entities, which may occur as single-organ vasculitis of the skin or present as skin-limited variant of systemic vasculitis (i.e., skin-limited ANCA-associated vasculitis), and are triggered by various factors, including infections, drugs and vaccines. The COVID-19 pandemic has challenged us with a variety of both disease- and vaccine-associated skin manifestations, including vasculitis. Among the latter, cutaneous small-vessel vasculitis, previously known as leukocytoclastic vasculitis, seems to be the most reported in either scenario, i.e., natural infection and vaccination. Vasculopathy without true vasculitic changes on histology develops in but a minority of cases, mostly severe/critical COVID-19 patients, and appears to be the result of endothelial injury due to pauci-immune thromboembolic mechanisms. Herein, we provide an overview of the available literature on COVID-19-associated and anti-SARS-CoV-2-vaccine-associated cutaneous vasculitis. Although evidence is mostly limited to isolated reports, with a proportion of cases lacking histopathological confirmation, ample overlap with pre-pandemic forms is shown.

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Section: Anti-sars-cov-2 Vaccination-induced Cutaneous Vasculitismentioning

confidence: 99%

“…Almost every case was biopsy-confirmed. Notably, some of these cases were reported as “immunocomplex vasculitides” ( 65 – 68 ). Some patients experienced systemic symptoms such as joint pain ( 64 , 70 , 73 , 80 , 84 ), and microhematuria ( 79 , 80 ).…”

Section: Anti-sars-cov-2 Vaccination-induced Cutaneous Vasculitismentioning

confidence: 99%

Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic

et al. 2022

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“…Vasculitis was the most common condition with nine cases. Therefore, Hocevar and colleagues implied that COVID-19 vaccinations might be associated with the induction of autoimmune and autoinflammatory diseases [ 65 ]. Elsalti elaborated on the slight increase of myocarditis following COVID-19 mRNA vaccination, particularly among young males.…”

Section: Covid-19 and Related Topics During Auto13mentioning

confidence: 99%

The mosaic of autoimmunity – Finally discussing in person. The 13th international congress on autoimmunity 2022 (AUTO13) Athens

Mahroum

Elsalti

Alwani

et al. 2022

Autoimmunity Reviews

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“…The outbreak of COVID-19, which is caused by SARS-CoV-2, began in December 2019 in Wuhan, Hubei, China, and then, it became a pandemic [ 5 ]. Among the morbidities associated with COVID-19, vascular complications, including vasculopathy, thrombotic microangiopathy, and intravascular coagulopathy, are of increasing concern because devastating vital organ injuries could be induced at various stages of the disease progression [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…With the advent of promising anti-COVID-19 vaccines, the SARS-CoV-2 pandemic was expected to quickly subside [ 6 ]. In line with this concept, the national vaccination program in Japan started on February 21, 2021, mainly by using the approved messenger RNA (mRNA) Comirnaty concentrate for dispersion of injection (Pfizer-BioNTech: Mainz, Germany).…”

Section: Introductionmentioning

confidence: 99%

A Case of Segmental Arterial Mediolysis of Multiple Visceral Arteries Following Anti-COVID-19 Vaccination: Late Complication or Rare Coincidence?

2022

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Patient: Male, 68-year-old Final Diagnosis: Segmental arterial mediolysis Symptoms: Abdominal pain Medication:— Clinical Procedure: — Specialty: General and Internal Medicine Objective: Unusual clinical course Background: Segmental arterial mediolysis (SAM) is a rare noninflammatory, nonatherosclerotic vascular disorder characterized by arterial media disruption. In conjunction with the SARS-CoV-2 infection or anti-COVID-19 vaccination, vascular disorders have been recognized as organ-specific immune-mediated complications, and the number of reported cases is gradually increasing. Case Report: A 68-year-old man presented with severe upper abdominal pain and nausea 58 days after a third injection of Pfizer-BioNTech anti-COVID-19 mRNA vaccination. An abdominal dynamic computed tomography angiography showed stenosis and dilatation of multiple visceral arteries, including the middle and right colic arteries. In the omental arteries, spindle-shaped dilatation and stenosis were identified. The left epiploic artery was not visualized, suggesting the development of occlusion due to arterial dissection. Based on these findings, SAM of multiple visceral arteries was diagnosed. Because the patient’s vital condition was stable, treatment by observation, with restriction of daily living, was chosen. Seventy-five days later, the pathological lesions in the affected vessels spontaneously resolved. Conclusions: While coincidence could not be completely excluded in this case, anti-COVID-19 mRNA vaccination should be noted for its potential association with SAM as a possible late complication.

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Vasculitis as Temporally Associated With COVID-19 Infection or Vaccination: A Single-center Experience

Cited by 13 publications

References 7 publications

Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic

Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic

The mosaic of autoimmunity – Finally discussing in person. The 13th international congress on autoimmunity 2022 (AUTO13) Athens

A Case of Segmental Arterial Mediolysis of Multiple Visceral Arteries Following Anti-COVID-19 Vaccination: Late Complication or Rare Coincidence?

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