Vasectomy and prostate cancer in Québec, Canada

Emard, Jean-François; Drouin, Guy; Thouez, Jean-Pierre; Ghadirian, Parviz

doi:10.1016/s1353-8292(01)00005-3

Cited by 12 publications

(16 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Vasectomy is a common method of male sterilization, whether it is linked to the increased risk of prostate cancer has been debated for many years. In 1980s, many case-control studies showed that vasectomy history was not linked to the increased risk of prostate cancer 22 23 , however, the following case-control studies suggested inconsistent results 24 25 26 . The selection and recall bias and smaller sample sizes of these case-control studies might limit the statistical effect and explained the varied findings.…”

Section: Discussionmentioning

confidence: 99%

Vasectomy and prostate cancer risk: a meta-analysis of cohort studies

Shang

Han

et al. 2015

Sci Rep

View full text Add to dashboard Cite

Some studies have suggested that vasectomy is associated with the increased risk of prostate cancer, however, this conclusion is not supported by all the published studies. In order to examine the relationship between vasectomy and prostate cancer risk, we conducted a meta-analysis of cohort studies to clarify this controversial association. PubMed and Medline were used to identify the cohort studies that reported the association of vasectomy with prostate cancer risk from 1980 to January 2015. Based on a random effects model, the RR and 95% CI were used to assess the combined risk. In total, 10 cohort studies involving more than 7027 cases and 429914 participants were included. There was no significant relationship between vasectomy and prostate cancer risk, the pooled RR (95%CI) was 1.11[0.98, 1.27] (P = 0.109). In subgroup-analysis, the relationship between vasectomy and prostate cancer risk was not significantly modified by the length of follow-up and population distribution except Americans. Omission of any single study had little effect on the pooled risk estimate. Little evidence of publication bias was found. In conclusion, our meta-analysis suggests that vasectomy is not associated with the increased risk of prostate cancer. More studies based on other populations including the Chinese are needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Vasectomy and prostate cancer risk: a meta-analysis of cohort studies

Shang

Han

et al. 2015

Sci Rep

View full text Add to dashboard Cite

show abstract

“…7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Potential biological mechanisms supporting an association between vasectomy and incident prostate cancer include increases in androgen levels, which are hypothesised to increase the risk of prostate cancer,31 and impaired secretory function of the prostate, which might prolong exposure of the prostate to carcinogenic factors 11. Although some studies have shown an increase in serum dihydrotestosterone and testosterone after vasectomy,32 33 34 others have found no statistically significant change in androgen levels 35…”

Section: Introductionmentioning

confidence: 99%

Vasectomy and risk of prostate cancer: population based matched cohort study

Nayan

Hamilton

Macdonald

et al. 2016

BMJ

View full text Add to dashboard Cite

Objective To determine the association between vasectomy and prostate cancer, adjusting for measures of health seeking behaviour.Design Population based matched cohort study.Setting Multiple validated healthcare databases in Ontario, Canada, 1994-2012.Participants 326 607 men aged 20 to 65 who had undergone vasectomy were identified through physician billing codes and matched 1:1 on age (within two years), year of cohort entry, comorbidity score, and geographical region to men who did not undergo a vasectomy.Main outcomes measures The primary outcome was incident prostate cancer. Secondary outcomes were prostate cancer related grade, stage, and mortality.Results 3462 incident cases of prostate cancer were identified after a median follow-up of 10.9 years: 1843 (53.2%) in the vasectomy group and 1619 (46.8%) in the non-vasectomy group. In unadjusted analysis, vasectomy was associated with a slightly increased risk of incident prostate cancer (hazard ratio 1.13, 95% confidence interval 1.05 to 1.20). After adjustment for measures of health seeking behaviour, however, no association remained (adjusted hazard ratio 1.02, 95% confidence interval 0.95 to 1.09). Moreover, no association was found between vasectomy and high grade prostate cancer (adjusted odds ratio 1.05, 95% confidence interval 0.67 to 1.66), advanced stage prostate cancer (adjusted odds ratio 1.04, 0.81 to 1.34), or mortality (adjusted hazard ratio 1.06, 0.60 to 1.85).Conclusion The findings do not support an independent association between vasectomy and prostate cancer.

show abstract

“…Epidemiological studies that associate vasectomy with prostate cancer are contradictory and inconclusive. Although some studies have indicated increased risk of prostate cancer in vasectomized men (Giovanucci et al, 1993a,b;Emard et al, 2001), another study reports that vasectomy decreases the relative risk (Ross et al, 1983), while others infer that there is no association between vasectomy and prostate cancer (Bernal-Delgado et al, 1998;Lesko et al, 1999;Cox et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Repercussions of castration and vasectomy on the ductal system of the rat ventral prostate

Pereira

Martinez

et al. 2006

Cell Biology International

View full text Add to dashboard Cite

Diseases, such as cancer and benign prostatic hyperplasia, are related to disruption of the mechanism regulating the balance between cell proliferation and apoptosis in prostatic cells. Since castration and vasectomy might alter that balance, this study evaluates the cell proliferation, apoptosis and height of the secretory epithelium of the ventral-prostate ductal system post-castration and vasectomy. Immunohistochemical (PCNA and Ki67), cytochemical (Fuelgen reaction) and morphometric investigation have been carried out. Cell proliferation indices decreased significantly in both regions of the ventral-prostate ductal system after castration compared to the sham-operated group. The apoptotic index increased significantly after 48 h, declining 7 days post-castration. The cell proliferation indices did not differ after 48 h significantly; however, they increased 7 days post-vasectomy in both regions. The apoptotic index did not differ significantly in either time post-vasectomy. Castration caused an imbalance in favor of apoptosis, whereas vasectomy caused an imbalance in favor of cell proliferation.

show abstract

Vasectomy and prostate cancer in Québec, Canada

Cited by 12 publications

References 44 publications

Vasectomy and prostate cancer risk: a meta-analysis of cohort studies

Vasectomy and prostate cancer risk: a meta-analysis of cohort studies

Vasectomy and risk of prostate cancer: population based matched cohort study

Repercussions of castration and vasectomy on the ductal system of the rat ventral prostate

Contact Info

Product

Resources

About