Vasectomy and the risk of prostate cancer in a Finnish nationwide population-based cohort

Seikkula, Heikki; Kaipia, Antti; Hirvonen, Elli; Rantanen, Matti; Pitkäniemi, Janne; Malila, Nea; Boström, Peter J.

doi:10.1016/j.canep.2019.101631

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…It was mainly focused on high-grade/low-grade cancer and lethality that increased overall risk of prostate cancer which reported by literatures ( Table 2 ) [ 44 45 46 47 ]. It has also been reported that the incidence of prostate cancer after vasectomy exhibits a slight increase, but mortality after vasectomy has been markedly reduced [ 48 ]. The reason may be that men who choose vasectomy are more willing to undergo regular testing for prostate-specific antigen so as to exclude prostate cancer, which is also related to a healthier lifestyle.…”

Section: Resultsmentioning

confidence: 99%

Review of Vasectomy Complications and Safety Concerns

Yang

Dong

et al. 2021

World J Mens Health

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Vasectomy is a simple, safe, effective, and economical method used worldwide for long-term male contraception. As a surgical operation, it has short-term and long-term complications such as hematoma formation, infection, sterilization failure, sperm granulomas, short-term postoperative pain (nodal pain, scrotal pain, and ejaculation pain), and chronic pain syndrome. Whether it increases the risk of autoimmune disease, cardiovascular disease, testicular cancer, or prostate cancer is still controversial. Changes in plasma concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone after vasectomy have also been studied, as well as the relation between vasectomy and sexual function. Sperm quality decreases very slowly after vasectomy, and vasovasostomy and intracytoplasmic sperm injection could help a couple achieve a pregnancy if they change their minds at any point. We include a follow-up strategy and suggestions for follow-up care at the end of this review.

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Section: Resultsmentioning

confidence: 99%

Review of Vasectomy Complications and Safety Concerns

Yang

Dong

et al. 2021

World J Mens Health

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“…Hasil Penelitian dan Pembahasan Berdasarkan sembilan belas artikel yang telah ditinjau, terdapat sepuluh artikel yang dapat menyimpulkan bahwa vasektomi dapat meningkatkan risiko kejadian kanker prostat (8) (17). Penelitian yang dilakukan oleh Giovannuci dkk menunjukkan bahwa vasektomi dikaitkan dengan rentang waktu setelah dilakukannya prosedur vasektomi yang didapatkan hasil dengan peningkatan risiko kanker prostat di antara pria yang menjalani vasektomi setidaknya pada 22 tahun yang lalu (12). Namun, Francois dkk menyimpulkan bahwa dalam penelitian mengenai hubungan vasektomi dengan kejadian kanker prostat, diketahui kemungkinan terdapat deteksi bias di antara individu yang melakukan vasektomi, sehingga mengakibatkan adanya peningkatan risiko kanker prostat setidaknya 10 tahun atau lebih setelah prosedur (14).…”

Section: Cunclassified

Analisis Vasektomi Sebagai Faktor Risiko Kejadian Kanker Prostat

Audia Hajera Bachtiar,

Ajeng Kartika Sari,

Eka Nurhayati

2024

BCSMS

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Abstract. Vasectomy or vas ligation is a method of contraception in men by cutting and tying the right and left of vas deferens with the aim of preventing spermatozoa from coming out during ejaculation. Vasectomy cannot be separated from long-term health risks, one of which is that men who undergo vasectomies have a 15% higher risk of developing prostate cancer overall. Prostate cancer is a type of cancer that develops from gland cells that produce prostate fluid combined with semen. The aim of this study is to provide information to readers regarding the relationship between vasectomy as a risk factor for prostate cancer. This research uses a scoping review study to identify and report several articles through Pubmed, ScienceDirect, SpringerLink, Taylor and Francis. The PRISMA diagram method was used in this research and resulted in nineteen articles that met the inclusion and eligibilty criteria. Based on results of the analysis, there are ten articles that can conclude that vasectomy could increase the risk of prostate cancer and nine articles concluded that vasectomy could not increase the risk of prostate cancer. Abstrak. Vasektomi atau vas ligation merupakan salah satu metode kontrasepsi pada pria dengan prosedur pemotongan dan pengikatan pada vas deferens kanan dan kiri dengan tujuan untuk mencegah spermatozoa keluar saat ejakulasi. Vasektomi tidak lepas dari dampak risiko kesehatan yang panjang, salah satunya yaitu pria yang menjalani vasektomi memiliki risiko 15% lebih tinggi terkena kanker prostat secara keseluruhan. Kanker prostat merupakan jenis kanker yang berkembang dari sel kelenjar yang menghasilkan cairan prostat yang tergabung dengan semen. Tujuan dari penelitian ini yaitu untuk memberikan informasi kepada pembaca mengenai hubungan vasektomi sebagai faktor risiko kejadian kanker prostat. Penelitian ini menggunakan studi scoping review untuk mengidentifikasi dan melaporkan beberapa artikel melalui sumber PubMed, ScienceDirect, SpringerLink, dan Taylor and Francis. Metode diagram PRISMA digunakan dalam penelitian ini dan menghasilkan sembilan belas artikel yang memenuhi kriteria inklusi dan kelayakan. Berdasarkan hasil analisis dan pembahasan dari uraian artikel penelitian yang ditinjau, sepuluh artikel menyimpulkan bahwa vasektomi dapat meningkatkan risiko kejadian kanker prostat dan sembilan artikel menyimpulkan bahwa vasektomi tidak dapat meningkatkan risiko kejadian kanker prostat.

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“…A total of 466 unique records were identified. Of these, 70 full-text articles were assessed for eligibility and 37 met the inclusion criteria for qualitative and quantitative analysis [4] , [6] , [7] , [8] , [9] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] . The reasons for exclusion are summarized in Figure 1 .…”

Section: Evidence Synthesismentioning

confidence: 99%

“…These discrepancies are due to the paucity of documented causal associations, and possible detection biases related to PCa screening and closer follow-up among vasectomy patients, and modest clinical significance with a relative risk very often close to 1. Recently, several large, high-quality reports demonstrated conflicting results [5] , [6] , [7] , [8] , [9] . A recent meta-analysis that included the most recent reports found that vasectomy was associated with localized and advanced PCa [10] .…”

Section: Introductionmentioning

confidence: 99%