Vasopressin levels in peripheral blood and in cerebrospinal fluid during passive and active avoidance behavior in rats

Greidanus, T.B. van Wimersma; Croiset, Gerda; Goedemans, Hans J.H.; Dogterom, J.

doi:10.1016/0018-506x(79)90016-3

Cited by 22 publications

(3 citation statements)

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“…Previous findings presented by Van Wimersma Greidanus et al (1979b) also support this hypothesis, although in that study CSF was withdrawn from the lateral ventricle and not from the cisterna magna as in the present experiments. This difference in CSF origin may account for the lower levels of AVP in CSF observed in the present experiment as compared to the previous study.…”

Section: Discussionsupporting

confidence: 84%

“…Thompson and De Wied (1973) have reported that the antidiuretic activity of eyeplexus blood in rats increased during a 24-hr postshock retention trial of a passive avoidance response. However, using a RIA, changes in AVP levels in peripheral blood and in ventricular CSF could not be demonstrated using various shock intensities during the learning trial, although these different shock intensities resulted in marked differences in avoidance latencies during retention (Van Wimersma Greidanus et al, 1979b). In the present study only one shock level was used during the learning trial and this induced a wide range of avoidance latencies during retention, which were not correlated to vasopressin levels in blood and CSF.…”

Section: Discussioncontrasting

confidence: 68%

“…Only 5 min after the onset of the retention session of a passive avoidance task a slight but significant elevation of plasma AVP levels was found in animals that displayed a long avoidance latency (Van Wimersma Greidanus, Croiset, Goedemans, and Dogterom, 1979b).…”

mentioning

confidence: 96%

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Neurohypophyseal peptide levels in CSF and plasma during passive avoidance behavior in rats

Mens

Egmond

Rotte

et al. 1982

Hormones and Behavior

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Levels of vasopressin (AVP), oxytocin (OXT), and neurophysin (NP) in CSF and plasma of rats were determined during acquisition and retention of passive avoidance behavior. None of the levels of neurohypophyseal peptides in CSF were changed either during the adaptation period, or during acquisition or the retention of this behavior. Moreover, no differences were found in hormone levels in CSF of the various groups of rats subjected to different shock intensities during the acquisition trial. The marked differences in individual latencies of nonavoiding rats, and the differences in latencies due to a different shock intensity applied during the learning trial were not reflected by changes in CSF hormone levels. Neither AVP nor NP levels in plasma were affected by the different shock intensities applied, when measured at 20 min after the learning trial. In contrast, a decrease in plasma OXT levels was observed after application of a shock intensity of 0.25 mA during the learning trial. During retention of the passive avoidance response plasma levels of AVP, OXT and NP were not different from the levels found in the nonshocked groups. It is suggested that under the conditions used in this study the CSF is apparently not involved in the distribution of neurohypophyseal peptides to their possible sites of behavioral action in the brain.Arginine-Svasopressin (AVP) and oxytocin (OXT) both modulate memory processes. AVP affects memory processes by facilitating both storage and retrieval of information (Ader and De Wied, 1972;Rigter, Van Riezen, and De Wied, 1974;De Wied, 1976), whereas OXT generally has an opposite effect. This latter neuropeptide may be a naturally occurring amnesic neuropeptide (Bohus, Kovacs, and De Wied, 1978a). Prom the effects of AVP in rats bearing lesions in various limbic structures as well as from the effects of locally applied vasopressin, it was suggested that AVP may act on intact midbrain limbic circuits, including

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Section: Discussionsupporting

confidence: 84%

Section: Discussioncontrasting

confidence: 68%