2012
DOI: 10.4161/cc.21927
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VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes

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Cited by 28 publications
(70 citation statements)
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References 48 publications
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“…Recently, a centrosome localization domain (CLD) was found in human Mps1 (amino acids 53-175), based on homology among vertebrate Mps1 proteins (23). This domain interacts with a novel centrosomal component voltage-dependent anion channel 3 (VDAC3), which is required for Mps1 localization to the centrosome (23).…”
mentioning
confidence: 99%
“…Recently, a centrosome localization domain (CLD) was found in human Mps1 (amino acids 53-175), based on homology among vertebrate Mps1 proteins (23). This domain interacts with a novel centrosomal component voltage-dependent anion channel 3 (VDAC3), which is required for Mps1 localization to the centrosome (23).…”
mentioning
confidence: 99%
“…Immunostaining of several mammalian cells including RPE1 cells using a VDAC3-specific antibody showed prominent centrosomal staining and comparatively weak mitochondrial staining. We also showed that centrosomal VDAC3 is preferentially associated with the mother centriole, and the centrosomal pool of both the endogenous and ectopically expressed VDAC3 is regulated by degradation 16 . In order to validate the quantitative IIF assay we examined the changes in the centrosome-associated VDAC3 pool in cells that are in S-phase.…”
Section: Representative Resultsmentioning
confidence: 90%
“…Our recent studies identified novel centrosomal localization and function of VDAC3, one of the mitochondrial porins 16,28 . Immunostaining of several mammalian cells including RPE1 cells using a VDAC3-specific antibody showed prominent centrosomal staining and comparatively weak mitochondrial staining.…”
Section: Representative Resultsmentioning
confidence: 99%
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