Abstract. In this work we characterize a high order Toda lattice in terms of a family of matrix polynomials orthogonal with respect to a complex matrix measure. In order to study the solution of this dynamical system we give explicit expressions for the Weyl function, generalized Markov function, and we also obtain, under some conditions, a representation of the vector of linear functionals associated with this system. We show that the orthogonality is embedded in these structure and governs the high order Toda lattice. We also present a Lax type theorem for the point spectrum of the Jacobi operator associated with a Toda type lattice.