Vegetable Purgatives Containing Anthracene Derivatives

Fairbairn, James; Saleh, M. R. I.

doi:10.1111/j.2042-7158.1951.tb13135.x

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Frangula Bark1

Discussion1

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1952

1993

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Cited by 17 publications

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References 7 publications

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“…However, there is enhanced activity in crude preparations of frangula due to synergism. We have reported similar syner gistic effects with the mixed glycosides of senna leaf (Fairbairn and Saleh, 1951). Auterhoff (1953) has also shown that mixtures of anthraquinone drugs produce synergism.…”

Section: Frangula Barkmentioning

confidence: 49%

Biological Assay and Its Relation to Chemical Structure

Jw¹

1976

Pharmacology

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Section: Frangula Barkmentioning

confidence: 49%

Biological Assay and Its Relation to Chemical Structure

Jw¹

1976

Pharmacology

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“…It has been shown that senna leaves have a higher relative risk based on aloe-emodin content than senna pods. The higher proportion of non-rhein-based anthranoids in the leaves has been reported by Fairbairn and Saleh [10]. In purified sennosides the risk is considerably less.…”

Section: Discussionmentioning

confidence: 64%

Analytics of Senna Drugs with Regard to the Toxicologicai Discussion of Anthranoids

Grimminger¹,

Witthohn²

1993

Pharmacology

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Toxicological studies indicate that two hydroxyanthraquinones (HAs), aloe-emodin and emodin, present as minor components in senna, might represent a genotoxic or cancerogenetic risk for man. Since aloe-emodin and emodin occur in senna in the free form as well as their glucosides and dianthrone glucosides, a HPLC method was established to allow the quantification of all free and glycosidic 1,8-dihydroxy anthranoids. The sum of the free HAs and their calculated content in each of their prodrug forms is defined as the potential HA content. For the comparison of different senna drugs in respect to the genotoxic risk arising from their potential aloe-emodin or emodin contents, a risk index has been established.

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Wissenswertes Für Die Pharmazeutische Praxis. Die Chemie und Pharmakologie pflanzlicher Laxantien

Schmidt¹

1960

Arch. Pharm. Pharm. Med. Chem.

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Vegetable Purgatives Containing Anthracene Derivatives

Cited by 17 publications

References 7 publications

Biological Assay and Its Relation to Chemical Structure

Biological Assay and Its Relation to Chemical Structure

Analytics of Senna Drugs with Regard to the Toxicologicai Discussion of Anthranoids

Wissenswertes Für Die Pharmazeutische Praxis. Die Chemie und Pharmakologie pflanzlicher Laxantien

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