VEGF −460C&gt;T polymorphism and cancer risk: a meta-analysis

Xu, Bingying; Feng, Na; Tong, Na; Wang, Zi-Dun; Zhang, Wei; Wu, Hongfei; Hua, Lin-Xin

doi:10.1007/s12032-009-9329-2

Cited by 16 publications

(12 citation statements)

References 25 publications

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“…The previous metaanalyses performed by Xu et al, 35 Hong et al, 36 and Liu et al 37 contained one study related to OC; those by Cao et al 38 and Hong et al 39 included 2 studies that tested OC. None of these 5 meta-analyses focused exclusively on OC, and none of them conducted subgroup analysis for OC.…”

Section: Discussionmentioning

confidence: 99%

Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, −460C > T, and −2578C > A) and Their Susceptibility to Ovarian Cancer

Zhang

Qin

Qin³

2015

International Journal of Gynecological Cancer

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Section: Discussionmentioning

confidence: 99%

Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, −460C > T, and −2578C > A) and Their Susceptibility to Ovarian Cancer

Zhang

Qin

Qin³

2015

International Journal of Gynecological Cancer

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“…VEGF gene -460T/C polymorphism, one of the most frequently seen polymorphisms, is located at the -460 position in the promoter region. VEGF gene promoter region contains multiple regulatory elements, which involved in the regulation of VEGF gene expression, and -460T/C polymorphism C allele showed 70% increased promoter activity over T allele [36,37]. Therefore, we speculate that -460T/C polymorphism may increase expression of VEGF , resulting in a increased susceptibility to DR. Of course, the detailed mechanisms need further study.…”

Section: Discussionmentioning

confidence: 99%

Association of VEGF Gene Polymorphisms with Diabetic Retinopathy: A Meta-Analysis

Gong

Sun

2013

PLoS ONE

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BackgroundStudies on the association of vascular endothelial growth factor (VEGF) gene -460T/C and -2578C/A polymorphisms with diabetic retinopathy (DR) have reported conflicting results. The aim of the present study was to assess the association by using meta-analysis.MethodsA systematic search of electronic databases (PubMed, EMBASE, Elsevier Science Direct, ISI Web of Science, CBM, CNKI and VIP) was carried out until Sept 18, 2013. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were used to assess the strength of the association.ResultsEleven studies (-460T/C: 6 studies including 932 cases and 722 controls; -2578C/A: 6 studies including 1,071 cases and 1,137 controls) were involved in this meta-analysis. Significant association was found for -460T/C polymorphism (C versus T: OR=1.48, 95%CI=1.07–2.05, P=0.02; TC+CC versus TT: OR=1.78, 95%CI=1.02–3.12, P=0.04; CC versus TT+TC: OR=1.76, 95%CI=1.10–2.81, P=0.02), but not for -2578C/A polymorphism (P>0.05). Similar results were found in the subgroup analysis.ConclusionsThis meta-analysis demonstrates that DR is associated with VEGF gene -460T/C polymorphism, but not -2578C/A polymorphism. Further case-control studies based on larger sample size are still needed, especially for -2578C/A polymorphism.

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“…There might be some other SNPs in VEGF associated with risk of cancer. Xu et al [24] conducted a meta-analysis of 14 studies showed the evidence that VEGF -460T was associated with increased cancer risk in Asians. Schneider et al [25] found that VEGF -1498C alleles contributed to the susceptibility of breast cancer in American population.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of vascular endothelial growth factor –2578C/A with cancer risk: evidence from 11263 subjects

et al. 2010

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Published data on the association between vascular endothelial growth factor (VEGF) -2578C/A polymorphism and cancer risk is inconclusive. To derive a more precise estimation of association between VEGF -2578C/A polymorphism and the risk of cancer, we performed a meta-analysis of 5415 cancer cases and 5848 controls from 16 published case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Our meta-analysis indicated that VEGF -2578C/A polymorphism was associated with the risk of colorectal cancer under homozygote comparison (OR=0.70, 95% CI=0.53-0.92), dominant model (OR=0.72, 95% CI=0.57-0.92), and recessive model (OR=0.82, 95% CI=0.67-1.01), although no evidence of association between VEGF -2578C/A polymorphism and cancer risk was observed as we compared in the pooled analyses (homozygote comparison: OR=0.97, 95% CI=0.81-1.16). More studies are needed to detect VEGF -2578C/A polymorphism and its association with cancer in different ethnic populations incorporated with environmental exposures in the susceptibility of different kinds of cancer.

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VEGF −460C>T polymorphism and cancer risk: a meta-analysis

Cited by 16 publications

References 25 publications

Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, −460C > T, and −2578C > A) and Their Susceptibility to Ovarian Cancer

Three Polymorphisms of Vascular Endothelial Growth Factor (+936C > T, −460C > T, and −2578C > A) and Their Susceptibility to Ovarian Cancer

Association of VEGF Gene Polymorphisms with Diabetic Retinopathy: A Meta-Analysis

Polymorphism of vascular endothelial growth factor –2578C/A with cancer risk: evidence from 11263 subjects

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