Vehicular Traffic–Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP)

Mordukhovich, Irina; Beyea, Jan; Herring, Amy H.; Hatch, Maureen; Stellman, Steven D.; Teitelbaum, Susan L.; Richardson, David B.; Millikan, Robert C.; Engel, Lawrence S.; Shantakumar, Sumitra; Steck, Susan E.; Neugut, Alfred I.; Rössner, Pavel; Santella, Regina M.; Gammon, Marilie D.

doi:10.1289/ehp.1307736

Cited by 85 publications

(87 citation statements)

References 51 publications

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“…This is consistent with the positive association between exposure to polycyclic aromatic hydrocarbons from car traffic and BC incidence, reported by the Long Island Breast Cancer Study. 24 The authors of the Taiwan study concluded that particle-induced ROS formation contributed to oxidative DNA damage that may mediate particle-induced carcinogenesis. 23 The finding that particles have oestrogenic and DNA-damaging effects suggests a potential mechanism for an effect on BC: if inhaled PM entered the circulatory system from the lungs, oestrogenic particles might find their way to breast tissue.…”

Section: Discussionmentioning

confidence: 99%

Atmospheric fine particulate matter and breast cancer mortality: a population-based cohort study

et al. 2016

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ObjectivesAtmospheric fine particulate matter (PM2.5) has multiple adverse effects on human health. Global atmospheric levels of PM2.5 increased by 0.55 μg/m3/year (2.1%/year) from 1998 through 2012. There is evidence of a causal relationship between atmospheric PM2.5 and breast cancer (BC) incidence, but few studies have investigated BC mortality and atmospheric PM2.5. We investigated BC mortality in relation to atmospheric PM2.5 levels among patients living in Varese Province, northern Italy.MethodsWe selected female BC cases, archived in the local population-based cancer registry, diagnosed at age 50–69 years, between 2003 and 2009. The geographic coordinates of each woman's place of residence were identified, and individual PM2.5 exposures were assessed from satellite data. Grade, stage, age at diagnosis, period of diagnosis and participation in BC screening were potential confounders. Kaplan-Meir and Nelson-Aalen methods were used to test for mortality differences in relation to PM2.5 quartiles. Multivariable Cox proportional hazards modelling estimated HRs and 95% CIs of BC death in relation to PM2.5 exposure.ResultsOf 2021 BC cases, 325 died during follow-up to 31 December 2013, 246 for BC. Risk of BC death was significantly higher for all three upper quartiles of PM2.5 exposure compared to the lowest, with HRs of death: 1.82 (95% CI 1.15 to 2.89), 1.73 (95% CI 1.12 to 2.67) and 1.72 (95% CI 1.08 to 2.75).ConclusionsOur study indicates that the risk of BC mortality increases with PM2.5 exposure. Although additional research is required to confirm these findings, they are further evidence that PM2.5 exposure is harmful and indicate an urgent need to improve global air quality.

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Section: Discussionmentioning

confidence: 99%

Atmospheric fine particulate matter and breast cancer mortality: a population-based cohort study

et al. 2016

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“…Recent studies examining air pollution exposure and breast cancer risk reported mixed results, one with no association,11 while the other found a positive association 12. However, the majority of studies to date focused on ambient air pollution, smoking and other sources that confer exposure that is, compared with PAH-contaminated workplaces,13–18 much lower in intensity.…”

Section: Introductionmentioning

confidence: 99%

Women’s occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer

Lee

Burstyn

Lai³

et al. 2018

Occup Environ Med

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ObjectiveTo estimate the association between occupational polycyclic aromatic hydrocarbon (PAH) exposure and female breast cancer.MethodsLifetime work histories for 1130 cases and 1169 controls from British Columbia and Ontario (Canada) were assessed for PAH exposure using a job-exposure matrix based on compliance measurements obtained during US Occupational Safety and Health Administration workplace safety inspections.ResultsExposure to any level of PAHs was associated with an increased risk of breast cancer (OR=1.32, 95% CI: 1.10 to 1.59), as was duration at high PAH exposure (for >7.4 years: OR=1.45, 95% CI: 1.10 to 1.91; ptrend=0.01), compared with women who were never exposed. Increased risk of breast cancer was most strongly associated with prolonged duration at high occupational PAH exposure among women with a family history of breast cancer (for >7.4 years: OR=2.79, 95% CI: 1.25 to 6.24; ptrend<0.01).ConclusionsOur study suggests that prolonged occupational exposure to PAH may increase breast cancer risk, especially among women with a family history of breast cancer.

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“…PAH exposure has also been linked to respiratory distress in asthmatic children (Gale et al 2012). Chronic exposure in adults has been linked to the development of breast, lung, gastrointestinal, and bladder cancers (Armstrong, Hutchinson, Unwin, and Fletcher 2004; Bosetti et al 2007; Mastrangelo, Fadda, and Marzia 1996; Mordukhovich et al 2016; Zhang et al 2016). Although the majority of studies investigating PAH-associated cancers have focused on occupational exposures (Bosetti et al 2007), a growing body of evidence has highlighted the need for additional research in residential settings (DellaVale et al 2016; Deziel et al 2014; Kang et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Domestic Exposure to Polycyclic Aromatic Hydrocarbons in a Houston, Texas, Environmental Justice Neighborhood

Sansom

Kirsch²,

Stone³

et al. 2018

Environmental Justice

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Polycyclic aromatic hydrocarbons (PAHs) are a class of >100 chemicals that naturally occur in coal tar, crude oil, and gasoline and can be manufactured as part of dyes, plastics, and pesticides. PAHs are complex environmental toxicants and exposure to them have been linked to adverse health outcomes including cancer, as well as diseases of the skin, liver, and immune system. Residents of the environmental justice neighborhood of Manchester, located on Houston’s East End, are disproportionally exposed to toxic pollutants from both industry and transportation infrastructure. Based on a longstanding community engagement partnership with the research team, neighborhood residents sought to better understand their domestic exposure to PAHs. Particulate wipes were used to collect dust from a marked area within the entryway of randomly selected homes to assess for the presence of PAHs. Nineteen of the 61 PAH analytes, including the Environmental Protection Administration’s 16 priority PAHs and the subgroup of 7 probable human carcinogens, were found in the sampled homes. Residents of the Houston neighborhood of Manchester potentially have significant domestic exposure to PAHs from combustion sources. More research is needed to assess the source of the PAHs and to better understand the potential health impacts of these exposures.

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Vehicular Traffic–Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP)

Cited by 85 publications

References 51 publications

Atmospheric fine particulate matter and breast cancer mortality: a population-based cohort study

Atmospheric fine particulate matter and breast cancer mortality: a population-based cohort study

Women’s occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer

Domestic Exposure to Polycyclic Aromatic Hydrocarbons in a Houston, Texas, Environmental Justice Neighborhood

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