Ventromedial Prefrontal Cortex and Amygdala Dysfunction During an AngerInduction Positron Emission Tomography Study in Patients With Major DepressiveDisorder With Anger Attacks

Dougherty, Darin D.; Rauch, Scott L.; Deckersbach, Thilo; Marci, Carl D.; Loh, Rebecca; Shin, Lisa M.; Alpert, Nathaniel M.; Fischman, Alan J.; Fava, Maurizio

doi:10.1001/archpsyc.61.8.795

Cited by 149 publications

(91 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…32 Morphological and functional abnormalities within the amygdala in individuals with MDD have also been consistently demonstrated. 13,33,34 As it is possible that the decreased functional connectivity of rPFCamygdala circuitry detected in our MDD group may relate to both executive and emotional dysfunction, future neuroimaging studies using tasks that investigate these functions would be of interest.…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

Kong

Chen

Tang

et al. 2013

J Psychiatry Neurosci

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

Kong

Chen

Tang

et al. 2013

J Psychiatry Neurosci

View full text Add to dashboard Cite

“…However, other studies have demonstrated negative correlations between amygdala and medial OFC (Hariri et al, 2000(Hariri et al, , 2003. Previous fMRI studies showing negative correlations between amygdala and OFC have employed event-related designs showing acute reactions to aversive stimuli (Dougherty et al, 2004;Shin et al, 2005). Our study, in contrast, employs 18 FDG-PET, which reflects an average of activity of a 30-min epoch.…”

Section: Implications Of Group Differences In Fronto-amygdala Correlamentioning

confidence: 90%

Amygdala–Prefrontal Disconnection in Borderline Personality Disorder

New

Hazlett

Buchsbaum

et al. 2007

Neuropsychopharmacol

259

160

View full text Add to dashboard Cite

Abnormal fronto-amygdala circuitry has been implicated in impulsive aggression, a core symptom of borderline personality disorder (BPD). We examined relative glucose metabolic rate (rGMR) at rest and after m-CPP (meta-chloropiperazine) with 18 fluorodeoxyglucose (FDG) with positron emission tomography (PET) in 26 impulsive aggressive (IED)-BPD patients and 24 controls. Brain edges/amygdala were visually traced on MRI scans co-registered to PET scans; rGMR was obtained for ventral and dorsal regions of the amygdala and Brodmann areas within the prefrontal cortex (PFC). Correlation coefficients were calculated between rGMR for dorsal/ventral amygdala regions and PFC. Additionally, amygdala volumes and rGMR were examined in BPD and controls. Correlations PFC/amygdala Placebo: Controls showed significant positive correlations between right orbitofrontal (OFC) and ventral, but not dorsal, amygdala. Patients showed only weak correlations between amygdala and the anterior PFC, with no distinction between dorsal and ventral amygdala. Correlations PFC/amygdala: m-CPP response: Controls showed positive correlations between OFC and amygdala regions, whereas patients showed positive correlations between dorsolateral PFC and amygdala. Group differences between interregional correlational matrices were highly significant. Amygdala volume/metabolism: No group differences were found for amygdala volume, or metabolism in the placebo condition or in response to meta-chloropiperazine (m-CPP). We demonstrated a tight coupling of metabolic activity between right OFC and ventral amygdala in healthy subjects with dorsoventral differences in amygdala circuitry, not present in IED-BPD. We demonstrated no significant differences in amygdala volumes or metabolism between BPD patients and controls.

show abstract

“…Note also that the aggression seen in psychopathy [a condition associated with high BAS activity (Cole and Zahn-Waxler, 1992;Gray, 1994)] is frequently goal directed, linked to the gain of monetary and sexual rewards or social status (Cornell et al, 1996). The reduced frontostriatal response with increasing BAS drive was associated with increased amygdala activity, a similar pattern to the experience of aggression (Dougherty et al, 2004). Similarly, individuals with intermittent explosive disorder show an exaggerated amygdala response and reduced vmPFC response to aggressive facial expressions relative to controls (Coccaro et al, 2007), whereas a comparable exaggerated pattern is found in participants carrying the low-expression variant of the MAO-A (monoamine oxidize A) polymorphism (Meyer-Lindenberg et al, 2006), associated with increased risk for violent behavior (Caspi et al, 2002).…”

Section: Bas Aggression and Rewardmentioning

confidence: 94%

“…The involvement of these structures has been identified by both human and comparative research (Davidson et al, 2000;Dielenberg and McGregor, 2001;Blair, 2003;Soloff et al, 2003;Izquierdo and Murray, 2004;Coccaro et al, 2007), with heightened aggression associated with decreased vmPFC activation (thought to reflect decreased control) and increased amygdala activation (reflecting increased negative affect) (Davidson et al, 2000;Dougherty et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Appetitive Motivation Predicts the Neural Response to Facial Signals of Aggression

et al. 2008

View full text Add to dashboard Cite

The "behavioral approach system" (BAS) (Gray, 1990) has been primarily associated with reward processing and positive affect. However, additional research has demonstrated that the BAS plays a role in aggressive behavior, heightened experience of anger, and increased attention to facial signals of aggression. Using functional magnetic resonance imaging, we show that variation in the BAS trait in healthy participants predicts activation in neural regions implicated in aggression when participants view facial signals of aggression in others. Increased BAS drive (appetitive motivation) was associated with increased amygdala activation and decreased ventral anterior cingulate and ventral striatal activation to facial signals of aggression, relative to sad and neutral expressions. In contrast, increased behavioral inhibition was associated with increased activation in the dorsal anterior cingulate, a region involved in the perception of fear and threat. Our results provide the first demonstration that appetitive motivation constitutes a significant factor governing the function of neural regions implicated in aggression, and have implications for understanding clinical disorders of aggression.

show abstract

Ventromedial Prefrontal Cortex and Amygdala Dysfunction During an AngerInduction Positron Emission Tomography Study in Patients With Major DepressiveDisorder With Anger Attacks

Abstract: These results suggest a pathophysiology of MDD + A that is distinct from that of MDD - A and that may be responsible for the unique clinical presentation of patients with MDD + A.

Cited by 149 publications

References 129 publications

Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

Amygdala–Prefrontal Disconnection in Borderline Personality Disorder

Appetitive Motivation Predicts the Neural Response to Facial Signals of Aggression

Contact Info

Product

Resources

About