Verbessertes Diagnoseverfahren zur Erkennung des Diabetes mellitus

Gutsche, H; Fichte, K; Hartmann, E.

doi:10.1007/bf01476050

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Für eine Einbeziehung des 1-Stunden-Wertes (7,22,23,24) gibt es keinen einsichtigen Grund, da die Blutzuckerwerte 60 Minuten nach oraler Gabe aufgrund unterschiedlicher Resorptionsgeschwindigkeiten stark streuen. Im Mittel lag die Differenz zwischen der höchsten und der niedrigsten Glucose-Konzentration des 2-Stunden-Wertes für aile^.50 Probanden bei 0,31 mmol/l.…”

Section: Bestimmung Der Glucose-konzentration Im Blutunclassified

Zur Reproduzierbarkeit der Ergebnisse des oralen Glucose-Toleranz-Tests

Heil¹,

Jachtmann²,

Rick³

1990

LaboratoriumsMedizin

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Zusammenfassung: An 50 ambulanten Probanden, die zum Zeitpunkt der Untersuchung nicht an einem manifesten Diabetes mellitus erkrankt waren, wurden jeweils drei orale Glucose-Toleranz-Tests in unterschiedlichen Abständen durchgeführt. Die Vorbereitung der Testpersonen auf die Funktionsprüfung erfolgte unter streng definierten Bedingungen. Für jeden einzelnen Probanden zeigte der 2-Stunden-Wert in der Differenz zwischen der höchsten und der niedrigsten Glucose-Konzentration die geringste Streuung mit einem Mediän von 0,31 mmol/l. Die 2,5.-Perzentile lag zu diesem Zeitpunkt bei 0,06 mmol/l und die 97,5.-Perzentile bei 0,56 mmol/l. Zu allen anderen Probennahmezeiten variierten die Glucose-Konzentrationen erheblich stärker. Aus den dargestellten Ergebnissen läßt sich Summary:' · 50 ambulant test persons without signs of diabetes mellitus at the time of examination underwent an oral glucose tolerance test three times in varying intervals. The preparation of the persons for the function test took place unter strictly defined conditions. For every single test person the 2 hour value showed the smallest variance in respect to the difference between the highest and lowest glucose concentration. The median at this time was found to be 0.31 mmol/l with the 2.5 percent!le at 0.06 mmol/l and the 97.5 percent!le at 0.56 mmol/l. At all other sampling times the glucose concentrations varied much more. The conclusion of the results shown in this paper is that it is only efficient to carry out an oral glucose tolerance test if the conditions for the preparation of the patient and the performance of the test are defined exactly.

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Section: Bestimmung Der Glucose-konzentration Im Blutunclassified

Zur Reproduzierbarkeit der Ergebnisse des oralen Glucose-Toleranz-Tests

Heil¹,

Jachtmann²,

Rick³

1990

LaboratoriumsMedizin

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Use and Usefulness of Diagnostic Tests. The Oral Glucose Tolerance Test and the So Called Chlorpropamide Alcohol Flush Test

Köbberling

1985

Prognose- Und Entscheidungsfindung in Der Medizin

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Are all glucose solutions used for oGTT equal?

Heinemann¹

2022

Diabet Med

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Aims Oral glucose tolerance tests (oGTT) are widely used for the diagnosis of diabetes. It is well known that the reproducibility of oGTT is poor and that a number of factors have an impact on the outcome of this diagnostic test. It appears as if one aspect, the oral glucose solution (OGS) used has not achieved much attention. Very little is published about this, despite the fact that apparently most often not a pure and freshly prepared glucose solution is used but a ready‐to‐use solution prepared by a (pharmaceutical) company. Methods A literature search was performed to find respective publications. Results It appears as if no or only a small number of not adequately designed clinical‐experimental studies have been performed comparing different OGS head‐to‐head. Conclusions The composition of such OGS, including the excipients added to improve taste and smell, can have an impact on blood glucose increase after drinking the given OGS. Such factors can also have an impact on endogenous insulin secretion. If significant differences in the blood glucose excursions exist depending on which OGS is used, this calls for the use of a standardized OGS in oGTT to have a comparable outcome everywhere.

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Verbessertes Diagnoseverfahren zur Erkennung des Diabetes mellitus

Cited by 3 publications

References 3 publications

Zur Reproduzierbarkeit der Ergebnisse des oralen Glucose-Toleranz-Tests

Zur Reproduzierbarkeit der Ergebnisse des oralen Glucose-Toleranz-Tests

Use and Usefulness of Diagnostic Tests. The Oral Glucose Tolerance Test and the So Called Chlorpropamide Alcohol Flush Test

Are all glucose solutions used for oGTT equal?

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