Verhalten von p-Nitrophenolglucuronid bei der Spaltung mit Minerals�uren

Abstract

The behaviour of p-nitrophenol and synthetic p-nitrophenol-glucuronide with mineral acids has been investigated. With sulfuric acid (33%) about 93% of the glucuronide derivative have been hydrolysed; the solution was heated in open vessel for 15 sec. With hydrochloric acid (6%) only about 65% of the conjugated p-nitrophenol have been converted to the free form. No losses were detected, when free p-nitrophenol was treated under the same conditions. Three other methods of hydrolysis have been applied.

Empfindlicher Nachweis von p-Nitrophenol in Blut und Urin mit HPLC nach E 605-Intoxikation

“…Dies ist eine Best~itigung analoger Untersuchungen unter differierenden Bedingungen der Hydrolyse mit Schwefels~iure [15]. Die Extraktionsrate von p-Nitrophenol im sauren Hydrolysat liegt bei nahezu 100%.…”

Priority toxic pollutants in human urine :

“…The behavior of £-nitrophenol and p-nitrophenyl Q-glucuronide with mineral acid has been investigated (220 (56).…”