Verlust der Proliferationsfähigkeit der Hepatozyten nach subtotaler Hepatektomie

Tuczek, H. V.; Rabes, H.

doi:10.1007/bf02147577

Cited by 29 publications

(13 citation statements)

References 2 publications

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“…3, 4). Discussion A 90% hepateetomy of the rat in one study reportedly led to 100% mortality within 48 h without regeneration of the remnant liver [9], In the present study, however, the rats pre treated with olive oil survived this drastic sur gery with low mortality (17%, 2/12, by natural survival analysis. 16% by Kaplan-Meier anal ysis).…”

Section: Resultscontrasting

confidence: 42%

Influences of Ciclosporin Pretherapyon 90&percnt; Hepatectomized Rats

Kim¹,

Kawano²,

Iwao³

et al. 1992

Eur Surg Res

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We studied the effect of ciclosporin (Cs) on rats which underwent a 90% hepatectomy. Rats were divided into two groups: group 1 (without Cs pretreatment) and group 2 (with Cs pre-treatment). Animals were given a 4-day treatment of Cs (10 mg/kg/day) prior to hepatectomy. The 1-week survival, serum biochemistry and parameters for hepatocyte proliferation (indices for mitosis and 5-bromo-2-deoxyuridine uptake) were serially investigated. Although Cs pretherapy significantly upregulated liver cell proliferation in group 2, there was no improvement in the survival rate of the immunosuppressed animals (group 2) compared to the controls (group 1). The implications of Cs pretherapy are discussed in the setting of extensive hepatectomy.

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Section: Resultscontrasting

confidence: 42%

Influences of Ciclosporin Pretherapyon 90&percnt; Hepatectomized Rats

Kim¹,

Kawano²,

Iwao³

et al. 1992

Eur Surg Res

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“…Liver regeneration after hepatectomy in rats is remarkably rapid; however, rats that have undergone excessive hepatectomy die from liver failure. 90% hepatectomy has been reported as a fatal model of acute liver failure in rats 16–18 . We have already reported that a portal‐systemic shunt after 90% hepatectomy significantly affects the survival rate 19 .…”

Section: Discussionmentioning

confidence: 95%

Improvement of the survival rate after rat massive hepatectomy due to the reduction of apoptosis by caspase inhibitor

Yoshida

Iwata

Yamada

et al. 2007

J of Gastro and Hepatol

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“…is not yet well understood, and so, to clarify it, numerous animal models have been established [1][2][3][4][5][6][7][8][9][10][11][12]. Previously, we clearly demonstrated that 90%-hepatectomy is a safety limit for rat hepatectomy.…”

Section: Introductionmentioning

confidence: 98%