A Good Model of Hepatic Failure after Excessive Hepatectomy in Mice

Makino, Hirochika; Togo, Shinji; Kubota, Takeshi; Morioka, Daisuke; Morita, Tomoyuki; Kobayashi, Takatoshi; Tanaka, Kuniya; Shimizu, Tetsuya; Matsuo, Keitaro; Nagashima, Yoji; Shimada, Hiroshi

doi:10.1016/j.jss.2005.04.029

Cited by 50 publications

(54 citation statements)

References 24 publications

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“…Due to the vital significance of the liver, one compensatory mechanism seems to be a deceleration of liver regeneration in favor of stabilization of liver function. This phenomenon is also observed after 90% PH, where proliferatory activity is reduced in comparison to 70% PH [40]. Other compensatory or protective mechanisms have also been described but not yet investigated in the present model.…”

Section: Discussionsupporting

confidence: 63%

Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy

Seehofer

Stockmann

Schirmeier

et al. 2007

Langenbecks Arch Surg

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Section: Discussionsupporting

confidence: 63%

Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy

Seehofer

Stockmann

Schirmeier

et al. 2007

Langenbecks Arch Surg

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“…Makino et al in their study, which aimed to find a safe limit of experimental liver resection, revealed that an extra massive 90% PH was lethal for mice. The cause of death was associated with severe acute liver failure induced by small residual liver [6]. All 90% hepatectomized mice in that study died within 24 h while all 70% hepatectomized mice survived.…”

Section: Introductionmentioning

confidence: 78%

Role of platelets on liver regeneration after 90% hepatectomy in mice

Myronovych

Murata

Chiba

et al. 2008

Journal of Hepatology

103

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“…3,12 In resections with removal of 40%-70% of the liver, there is a linear association between the amount of tissue resected and the extent of hepatocyte proliferation, 13 but resection of more than 70% results in increased mortality. 14 It has been demonstrated that in mice a 30% hepatectomy elicits the priming reaction, but fails to induce cell-cycle progression. 15 We found no difference in recovery after 240 hours between 50% and 70% resection.…”

Section: Discussionmentioning

confidence: 99%

Effect of different liver resection methods on liver damage and regeneration factors VEGF and FGF-2 in mice

et al. 2012

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Background: Different approaches to study liver regeneration in murine models have been proposed. We investigated the effect of different liver resection models on liver damage and regeneration parameters in mice. Methods:We compared the technical aspect of the 2 most commonly used techniques of 50% and 70% liver resection. Liver damage, as determined by the change in serum alanine aminotransferase and aspartate aminotransferase, as well as the regeneration parameters VEGF and FGF-2 were analyzed at 6 time points. A postoperative vitality score was introduced.Results: Cholestasis was not observed for either technique. Both resection techniques resulted in full weight recovery of the liver after 240 hours, with no significant difference between sham and resection groups. Postoperative animal morbidity and total protein levels did not differ significantly for either method, indicating early and full functional recovery. However, comparing the mitogenic growth factors FGF-2 and VEGF, a significant increase in serum levels and, therefore, increased growth stimulus, was shown in the extended resection group. Conclusion:Extended resection led to a greater response in growth factor expression. This finding is important since it shows that growth factor response differs acdording to the extent of resection. We have demonstrated the need to standardize murine hepatic resection models to adequately compare the resulting liver damage.Contexte : Différentes approches ont été proposées pour étudier la régénérescence du foie dans des modèles murins. Nous avons exploré l'effet de divers modèles de résection sur l'atteinte hépatique et les paramètres de la régénérescence chez la souris. Méthodes :Nous avons comparé l'aspect technique des 2 approches les plus couramment utilisées, soit les résections de 50 % et de 70 % du foie. L'atteinte hépatique, déter-minée en fonction de la modification des taux d'alanine aminotransférase et d'aspartate aminotransférase sériques, ainsi que les paramètres de régénérescence VEGF (facteur de croissance endothéliale vasculaire) et FGF-2 (facteur de croissance des fibroblastes) ont été analysés à 6 moments. Un score de vitalité postopératoire a en outre été introduit.

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A Good Model of Hepatic Failure after Excessive Hepatectomy in Mice

Cited by 50 publications

References 24 publications

Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy

Intraabdominal bacterial infections significantly alter regeneration and function of the liver in a rat model of major hepatectomy

Role of platelets on liver regeneration after 90% hepatectomy in mice

Effect of different liver resection methods on liver damage and regeneration factors VEGF and FGF-2 in mice

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