Versatile ligands for high-performance liquid chromatography: An overview of ionic liquid-functionalized stationary phases

Preparation and evaluation of 2-methylimidazolium-functionalized silica as a mixed-mode stationary phase for hydrophilic interaction and anion-exchange chromatography

“…ILs have been widely used in two aspects in high performance liquid chromatography (HPLC), which are either added in mobile phase as additives to shelter the adverse effect of residual silanols on separation of basic compounds [17][18][19] or bonded to stationary phases for chromatographic packing. Different with conventional stationary phases, ILs stationary phases can exhibit more interactions with solutes, including hydrophobic, -, electrostatic, hydrogen bonding and ion-dipole interactions [20], so it is very important for the development of mixed-mode chromatography.…”

Ionic liquids as mobile phase additives for determination of thiocyanate and iodide by liquid chromatography

“…The unique properties of ILs result in wide use in the fields of organic synthesis [1][2][3], catalysis [3,4], electrochemistry [5,6], nanotechnology [7], and analytical chemistry [8][9][10][11]. In recent years, the applications of ILs in the fields of GC stationary phases [12], LC stationary phases [13][14][15][16][17][18] and mobile phase additives [19,20] have received increasing attention. There are some reports on the analysis of organic substances such as alkaloids [21][22][23][24][25] and metal ions [26][27][28] by using ionic liquids as mobile phase additives, but there are few reports on the analysis of anions [29,30] which needs to be further studied extensively.…”

A new version of hydrophilic interaction liquid chromatography with the use of ionic liquids based on imidazole for the determination of highly polar drugs in body fluids

“…Роль таких реаген-тов могут выполнить ионные жидкости (ИЖ) на ос-нове имидазола, способные модифицировать не-подвижную фазу, образуя многослойные покрытия, а наличие имидазолиевого катиона и алкильных радикалов в структуре ионных жидкостей обеспе-чивает им дополнительные взаимодействия (элек-тростатические, p-π, гидрофобные, образование во-дородных связей) как с неподвижной фазой, так и с определяемым веществом [9][10][11][12], что может ока-заться дополнительным резервом в увеличении се-лективности разделения аналитов. Стационарные фазы на основе ионных жидкостей обычно получают путем ковалентной модификации сорбента [13][14][15][16][17][18][19].…”