Versatility of ‘hemorheologic fitness’ according to exercise intensity: emphasis on the “healthy primitive lifestyle”

Brun, J.‐F.; Varlet‐Marie, Emmanuelle; Chevance, Guillaume; Pollatz, M.; Fédou, C.; Mauverger, Éric Raynaud de

doi:10.1007/s13367-014-0029-x

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…Sedentary subjects undergo a host of metabolic (and hemorheologic) modifications that aim at coping with the lack of physiological activity, which represents a pathologic situation in these populations [259]. We previously published data in agreement with this theory, thus integrating them into a logical picture of hemorheologic homeostasis [260].…”

Section: Discussionmentioning

confidence: 89%

Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis

et al. 2021

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Many factors in the surrounding environment have been reported to influence erythrocyte deformability. It is likely that some influences represent reversible changes in erythrocyte rigidity that may be involved in physiological regulation, while others represent the early stages of eryptosis, i.e., the red cell self-programmed death. For example, erythrocyte rigidification during exercise is probably a reversible physiological mechanism, while the alterations of red blood cells (RBCs) observed in pathological conditions (inflammation, type 2 diabetes, and sickle-cell disease) are more likely to lead to eryptosis. The splenic clearance of rigid erythrocytes is the major regulator of RBC deformability. The physicochemical characteristics of the surrounding environment (thermal injury, pH, osmolality, oxidative stress, and plasma protein profile) also play a major role. However, there are many other factors that influence RBC deformability and eryptosis. In this comprehensive review, we discuss the various elements and circulating molecules that might influence RBCs and modify their deformability: purinergic signaling, gasotransmitters such as nitric oxide (NO), divalent cations (magnesium, zinc, and Fe++), lactate, ketone bodies, blood lipids, and several circulating hormones. Meal composition (caloric and carbohydrate intake) also modifies RBC deformability. Therefore, RBC deformability appears to be under the influence of many factors. This suggests that several homeostatic regulatory loops adapt the red cell rigidity to the physiological conditions in order to cope with the need for oxygen or fuel delivery to tissues. Furthermore, many conditions appear to irreversibly damage red cells, resulting in their destruction and removal from the blood. These two categories of modifications to erythrocyte deformability should thus be differentiated.

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Section: Discussionmentioning

confidence: 89%

Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis

et al. 2021

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“…Such a lifestyle is adapted to the "thrifty genotype" inherited from our Paleolithic ancestors because of its effects on energy metabolism and eating behavior. This concept also provides an explanation of some of the unexpected findings on relationships between rheological properties of blood and exercise in sedentary subjects and athletes [85].…”

Section: Physiological Relevance and Determinants Of Lipoxmaxmentioning

confidence: 86%

“…There is a continuum for plasma viscosity, which is lower in athletes than in low-intensity-trained, and even more sedentary, individuals. As humans since prehistoric periods performed a great deal of daily low-intensity exercise at this level, it is logical to assume that it was a part of the "healthy primitive lifestyle", and thus, that a decrease in plasma viscosity is one of the biological consequences of this lifestyle, likely with some to cardiovascular health [85].…”

Section: Lipoxmax Training Also Decreases Blood Viscositymentioning

confidence: 99%

Beyond the Calorie Paradigm: Taking into Account in Practice the Balance of Fat and Carbohydrate Oxidation during Exercise?

et al. 2022

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Recent literature shows that exercise is not simply a way to generate a calorie deficit as an add-on to restrictive diets but exerts powerful additional biological effects via its impact on mitochondrial function, the release of chemical messengers induced by muscular activity, and its ability to reverse epigenetic alterations. This review aims to summarize the current literature dealing with the hypothesis that some of these effects of exercise unexplained by an energy deficit are related to the balance of substrates used as fuel by the exercising muscle. This balance of substrates can be measured with reliable techniques, which provide information about metabolic disturbances associated with sedentarity and obesity, as well as adaptations of fuel metabolism in trained individuals. The exercise intensity that elicits maximal oxidation of lipids, termed LIPOXmax, FATOXmax, or FATmax, provides a marker of the mitochondrial ability to oxidize fatty acids and predicts how much fat will be oxidized over 45–60 min of low- to moderate-intensity training performed at the corresponding intensity. LIPOXmax is a reproducible parameter that can be modified by many physiological and lifestyle influences (exercise, diet, gender, age, hormones such as catecholamines, and the growth hormone-Insulin-like growth factor I axis). Individuals told to select an exercise intensity to maintain for 45 min or more spontaneously select a level close to this intensity. There is increasing evidence that training targeted at this level is efficient for reducing fat mass, sparing muscle mass, increasing the ability to oxidize lipids during exercise, lowering blood pressure and low-grade inflammation, improving insulin secretion and insulin sensitivity, reducing blood glucose and HbA1c in type 2 diabetes, and decreasing the circulating cholesterol level. Training protocols based on this concept are easy to implement and accept in very sedentary patients and have shown an unexpected efficacy over the long term. They also represent a useful add-on to bariatric surgery in order to maintain and improve its weight-lowering effect. Additional studies are required to confirm and more precisely analyze the determinants of LIPOXmax and the long-term effects of training at this level on body composition, metabolism, and health.

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“…13 Sementara pada penelitian Astuti et al 2 , Marie et al 16 , Brun et al 17 Saat melakukan latihan yang intens juga akan terjadi hemokonsentrasi atau peningkatan hematoktit, tetapi selama proses pemulihan terjadi fenomena yang dikenal dengan istilah auto hemodilusi di mana terjadi peningkatan kadar air yang lebih tinggi dalam plasma dan dengan demikian hematokrit dan viskositas menjadi lebih rendah. 18 Istilah auto hemodilusi ini disebutkan untuk menggambarkan ekpansi volume plasma yang mengikuti dehidrasi waktu singkat yang disebabkan oleh berolahraga. 16 Hemodilusi atau hematokrit yang menurun disebabkan karena penurunan eritrosit atau peningkatan kadar plasma darah.…”

Section: Crosssectionalunclassified

Literature Review: Hubungan Kadar Hematokrit dengan Nilai VO2 Maks pada Atlet

Norwidianti

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Huldani

2022

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Sport is defined as a subcategory of physical activity that is carried out systematically and progressively. Maximum oxygen consumption (VO2 max) is an indicator to determining an athlete’s fitness in achieving goals. VO2 max in a person largely depends on the efficient transport of oxygen to active tissues. Hematocrit is one indicator that plays a role in oxygen transport to active tissues. The purpose of writing this literature review is to make a review on the relationship between hematocrit levels and VO2 max values in athletes. The reviewed articles were obtained from search results on Google Scholar and PubMed. The articles included are in English and Indonesian, published in 2011-2021. There are differences in results between studies related to the relationship between hematocrit levels and VO2 max values in athletes due to differences in several influencing factors such as gender, physical exercise, dehydration, body fat composition, as well as haemoconcentration and auto-hemodilution phenomena. Keywords: correlations, hematocrit, VO2 max, athletes Abstrak: Olahraga didefinisikan sebagai sub kategori dari aktivitas fisik yang dilakukan secara sistematik dan progresif. Konsumsi oksigen secara maksimal (VO2 maks) merupakan indikator untuk menentukan kebugaran atlet dalam upaya menggapai prestasi. VO2 maks pada seseorang sebagian besar tergantung dari transport oksigen yang efisiensi ke jaringan yang aktif. Hematokrit merupakan salah satu indikator yang berperan terhadap transport oksigen pada jaringan yang aktif. Tujuan penulisan literature review ini adalah yaitu untuk membuat tinjauan tentang hubungan antara kadar hematokrit dengan nilai VO2 maks pada atlet. Artikel yang direview didapatkan dari hasil pencarian pada Google Scholar dan PubMed. Artikel yang disertakan menggunakan bahasa Inggris dan Indonesia yang dipublikasikan pada tahun 2011-2021. Terdapat perbedaan hasil antar penelitian terkait hubungan kadar hematokrit dengan nilai VO2 maks pada atlet yang disebabkan adanya perbedaan pada beberapa faktor yang memengaruhi seperti jenis kelamin, latihan fisik, dehidrasi, komposisi lemak tubuh, serta fenomena hemokonsentrasi dan auto hemodilusi. Kata-kata kunci: hubungan, hematokrit, VO2 maks, atlet

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Versatility of ‘hemorheologic fitness’ according to exercise intensity: emphasis on the “healthy primitive lifestyle”

Cited by 5 publications

References 35 publications

Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis

Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis

Beyond the Calorie Paradigm: Taking into Account in Practice the Balance of Fat and Carbohydrate Oxidation during Exercise?

Literature Review: Hubungan Kadar Hematokrit dengan Nilai VO2 Maks pada Atlet

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