Burn accidents present a relevant frequency in Brazil and worldwide, maintaining high morbidity and mortality rates. Burn care requires long treatment, numerous consultations, dressing changes and long hospital stays, generating high costs for the health system. The objective of this study is to propagate the theme to increase the understanding of the recent biological dressing with the use of tilapia skin and its applicability in the treatment of burns. The innovative method created in Brazil, has as principle the use of tilapia skin for dressing on burns, with eminent potential in medicine for the treatment of these wounds, where the technique with “biological dressing” has been used since 2016. 19 contributed to a significant increase in burns due to the use of alcohol, both liquid and gel, in the home environment and many accidents with child burns. This study is of an applied nature, exploratory objective, qualitative approach and bibliographic procedure from reliable scientific bases, with a 10-year periodicity, where studies were found, reinforcing the effectiveness of the use of tilapia skin, as well as its benefits , histological features and tests in humans. The research was conducted at the Federal University of Mato Grosso do Sul (UFMS) – Faculty of Medicine (FAMED). The research demonstrated that the biological dressing with tilapia skin is an innovative method in the treatment of burns, being a high quality bioproduct, showing biological capacity to cover burns, collagen properties, tensiometric strength and a biomaterial potential in regenerative medicine.