Vibrio cholerae GbpA elicits necrotic cell death in intestinal cells

Mandal, Sudipto; Chatterjee, Nando K.

doi:10.1099/jmm.0.000298

Cited by 8 publications

(7 citation statements)

References 43 publications

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“…P. aeruginosa releases various effectors, including quorum-sensing molecules, phenazines, cyanide, and siderophores that attenuate mitochondrial OXPHOS [ 7 , 54 ]. V. cholerae also induces mitochondrial bioenergetic dysfunction, characterized by ROS generation through its virulence factors GbpA [ 55 ] and cholix toxin [ 56 ]. Many of the effectors that induce mitochondrial apoptosis discussed above similarly attenuate mitochondrial respiration by disrupting the mitochondrial membrane potential.…”

Section: How Bacteria Cause Mitochondrial Dysfunctionmentioning

confidence: 99%

Mitochondrial Dysfunction in Bacterial Infections

Maurice

Sadikot

2023

Pathogens

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Mitochondria are critical in numerous cellular processes, including energy generation. Bacterial pathogens target host cell mitochondria through various mechanisms to disturb the host response and improve bacterial survival. We review recent advances in the understanding of how bacteria cause mitochondrial dysfunction through perturbations in mitochondrial cell-death pathways, energy production, mitochondrial dynamics, mitochondrial quality control, DNA repair, and the mitochondrial unfolded protein response. We also briefly highlight possible therapeutic approaches aimed at restoring the host mitochondrial function as a novel strategy to enhance the host response to bacterial infection.

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Section: How Bacteria Cause Mitochondrial Dysfunctionmentioning

confidence: 99%

Mitochondrial Dysfunction in Bacterial Infections

Maurice

Sadikot

2023

Pathogens

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“…In addition, V . cholerae disrupts mitochondrial function by elevating ROS production through the production of Chx and GbpA, two virulence factors that promote intestinal colonization by suppressing the immune response and increasing mucus production, respectively [116,117]. V .…”

Section: Bacterial Effectors That Target Mitochondriamentioning

confidence: 99%

“…OM, outer membrane; IM, inner membrane; OMM, outer mitochondrial membrane; IMM, inner mitochondrial membrane. promote intestinal colonization by suppressing the immune response and increasing mucus production, respectively [116,117]. V. cholerae also produces cytolysin (VCC), a pore-forming toxin that leads to permeabilization of target cell membranes [118].…”

Section: Vibrio Choleraementioning

confidence: 99%

On the offense and defense: mitochondrial recovery programs amidst targeted pathogenic assault

2021

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review, we will provide an overview of mitochondrial recovery programs including mitochondrial dynamics, the mitochondrial unfolded protein response (UPR mt ), and mitophagy. We will then discuss the various approaches used by bacterial pathogens to target mitochondria, which result in mitochondrial dysfunction. Lastly, we will discuss how cells leverage mitochondrial recovery programs beyond their role in organelle repair, to promote host defense against pathogen infection.

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“…GbpA induces mucin secretion by intestinal epithelium, and mucin increases expression of GbpA [21]. Studies also determined that GbpA can induce necrosis of intestinal cells by increasing their membrane permeability [28]. Recently, a chitin cleavage activity under copper saturation has been described for GbpA and would therefore make it a lytic polysaccharide monooxygenase, a metalloenzyme copper-dependant capable of polysaccharide cleavage by oxidation [29].…”

Section: Secreted Proteinsmentioning

confidence: 99%

The Secretome of Vibrio cholerae

Mathieu-Denoncourt¹,

Giacomucci²,

Duperthuy³

2021

Infections and Sepsis Development

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Vibrio cholerae is a facultative human pathogen responsible for the cholera disease which infects millions of people worldwide each year. V. cholerae is a natural inhabitant of aquatic environments and the infection usually occurs after ingestion of contaminated water or food. The virulence factors of V. cholerae have been extensively studied in the last decades and include the cholera toxin and the coregulated pilus. Most of the virulence factors of V. cholerae belong to the secretome, which corresponds to all the molecules secreted in the extracellular environment such as proteins, exopolysaccharides, extracellular DNA or membrane vesicles. In this chapter, we review the current knowledge of the secretome of V. cholerae and its role in virulence, colonization and resistance. In the first section, we focus on the proteins secreted through conventional secretion systems. The second and third sections emphasize on the membrane vesicles and on the secretome associated with biofilms.

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Vibrio cholerae GbpA elicits necrotic cell death in intestinal cells

Cited by 8 publications

References 43 publications

Mitochondrial Dysfunction in Bacterial Infections

Mitochondrial Dysfunction in Bacterial Infections

On the offense and defense: mitochondrial recovery programs amidst targeted pathogenic assault

The Secretome of Vibrio cholerae

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