Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

Martino, Emanuela; Casamassima, Giuseppe; Deschênes, Marie-France; Cellupica, Edoardo; Pantalone, Serena; Papagni, Francesca; Rui, Marta; Siciliano, Angela Marika; Collina, Simona

doi:10.1016/j.bmcl.2018.06.044

Cited by 261 publications

(227 citation statements)

References 97 publications

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“…Seedlings were separately transplanted into individual pots (18.2 cm × 14.2 cm) and treated with 0 (control), 80, 200 and 300 mg/L copper sulphate (CuSO 4 ) for eight weeks. Nutrient solutions were renewed every 4 days . At the end of the treatment (in December), the fresh leaves were separated, and dried in a drying room with active ventilation at room temperature (about 26–28°C) until constant weight.…”

Section: Methodsmentioning

confidence: 99%

“…We prepared the hydroalcoholic leaves extract by applying the MASE methodology we had previously developed and reported and analysed by HPLC‐UV/PAD, at 1 mL/min flow rate, at room temperature using a Phenyl X‐Bridge endcapped column (50 mm × 4.6 mm, length × inner diameter, 3 μm particle size, macropore size 2 μm, mesopore size 13 nm, Merck, Darmstadt, Germany). The mobile phase consisted of water containing 0.1% ( v / v ) formic acid (A) and methanol containing 0.1% ( v/v ) formic acid (B).…”

Section: Methodsmentioning

confidence: 99%

“…The extensive use of plants for millennia for healthcare purposes has found renewed interest due to recent advances in modern biology, pharmacology, chemistry and related disciplines . The integration of traditional and modern medicine has given birth to “Green Medicine”; which has been proven to be more effective with fewer side effects on human beings.…”

Section: Introductionmentioning

confidence: 99%

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The use of a microwave‐assisted solvent extraction coupled with HPLC‐UV/PAD to assess the quality of Marrubium vulgareL. (white horehound) herbal raw material

Martino

Volpe

Cavalloro

et al. 2019

Phytochemical Analysis

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Introduction Marrubium vulgare is a herbal remedy presents in several European Pharmacopoeias and commonly marketed as white horehound. The chemotaxonomic marker of Marrubium genus is marrubiin and its content may change in response to biotic and abiotic stress. Objective Development of a microwave‐assisted solvent extraction (MASE) methodology suitable for exhaustively extracting marrubiin from M. vulgare leaves, easily applicable to large sets of samples. Evaluation of the influence of copper(II) on marrubiin production. Material and methods M. vulgare leaves were dried, extracted exploiting MASE and analysed via high‐performance liquid chromatography ultraviolet photodiode array detection (HPLC‐UV/PAD) system. A design of experiments approach was adopted to select the best extraction conditions. Extraction parameters (solvent composition, extraction time and temperature), were studied applying two full factorial experimental designs in a sequential approach. To analyse samples, a rapid HPLC‐UV/PAD method was set up. Results The best results in terms of marrubiin extraction yield were obtained extracting samples at 120°C with 100% ethanol, for 15 min (3 × 5 min microwave cycles). The developed methodology was successfully applied to matrices grown in Greenhouse conditions and under stress induced by copper(II), selected as model agent for abiotic stress. Progressively decreasing production of marrubiin was evidenced in connection with treatment with 80, 200 and 300 mg/L copper sulphate. Conclusion An efficient methodology for the extraction and determination of the amount of marrubiin in large sets of samples of M. vulgare plants was developed. Results demonstrated that marrubiin is an easily detectable marker useful for evaluating M. vulgare reaction to stress.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The use of a microwave‐assisted solvent extraction coupled with HPLC‐UV/PAD to assess the quality of Marrubium vulgareL. (white horehound) herbal raw material

Martino

Volpe

Cavalloro

et al. 2019

Phytochemical Analysis

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“…For instance, vinblastine, vinorelbine, vincristine, vindesine and vinflunine are five major vinca alkaloids derived from the Madagascar periwinkle plant (Catharanthus roseus G. Don, also called Vinca rosea) . Vinca alkaloids are the earliest natural plant‐derived antimitotic compounds approved to be used in clinic . Besides vinblastine and vincristine which are natural vinca alkaloids, vinorelbine, vindesine and vinflunine are semisynthetic derivatives .…”

Section: Introductionmentioning

confidence: 99%

“…Currently, these compounds are used to treat various types of human cancers with aggressive behaviour. In particular, vinca alkaloids are broadly used in management of leukaemia, colorectal cancer, melanoma, glioma, osteosarcoma, testicular cancer, small cell lung cancer and breast cancer, either alone or in combination with other chemotherapeutic agents …”

Section: Introductionmentioning

confidence: 99%

Pharmacological properties and therapeutic potential of saffron (Crocus sativus L.) in osteosarcoma

Eğe

Yumrutaş

Ege

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives In this comprehensive study, we aimed to investigate pharmacological properties and therapeutic significance of saffron in osteosarcoma cancer cells. Methods Plant materials were obtained from Safranbolu district of Karabuk, Turkey. For the determination of anticancer properties, thiazolyl blue tetrazolium bromide (MTT) cell viability, colony formation, wound closure, DNA ladder assays and gene expression analysis by real‐time PCR were performed. Also, cellular inflammation, total antioxidant and oxidants status were determined. Key findings Dichloromethane and hexane extracts of saffron were significantly inhibited cell proliferation and interfered with colony forming and migration capabilities of U2‐OS osteosarcoma cancer cells. Also, both extracts induced the activation of tumour suppressor CDKN2B gene and altered cellular morphology resembling the induction of apoptosis. However, DNA fragmentation was not observed after extract treatments. Saffron was also found to have no significant effect on cellular inflammation. Unexpectedly, both dichloromethane and hexane extracts of saffron had no marked effect on cellular total antioxidant and oxidant status. Lastly, vanillic acid, resveratrol, caffeic acid and 4‐hydroxybenzoic acid were found to be highly rich in our extracts. Conclusions Findings of this study demonstrated significant antiproliferative and antitumorigenic properties of saffron in osteosarcoma.

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Natural Products as Cytotoxic Agents

Pullman,

León,

Cutler

2021

Burger's Medicinal Chemistry and Drug Discovery

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Nature has proved to be a wellspring of important antineoplastic agents. In recent years, there has been a resurgence in the study of natural products with an emphasis on the discovery of novel therapeutic agents. New technologies and approaches such as high‐throughput screening, parallel synthesis, and other programs has facilitated this increased interest in natural products research. The scientific literature indicates that natural sources not previously considered as bioactive have in fact, become potential valuable treasure troves of novel chemical structures. For example, marine products from diverse sources such as thermal vents, sponges, terrestrial thermal vents, glacial cryogenic organisms, and xerophytic and endophytic organisms now give rise to a vast assortment of microorganisms. Additionally, the study of the biosynthetic machineries and biochemical process in microorganism has enhanced the research of cryptic natural products, fueling the search for natural products in the treatment of cancer. It comes as no surprise that nature biosynthesizes chemical compounds that chemists have not considered even in their imaginations. Although this article provides a few of these examples, it is certain that more will be present in the literature as the intellectual property in these discoveries are protected.

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Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

Cited by 261 publications

References 97 publications

The use of a microwave‐assisted solvent extraction coupled with HPLC‐UV/PAD to assess the quality of Marrubium vulgareL. (white horehound) herbal raw material

The use of a microwave‐assisted solvent extraction coupled with HPLC‐UV/PAD to assess the quality of Marrubium vulgareL. (white horehound) herbal raw material

Pharmacological properties and therapeutic potential of saffron (Crocus sativus L.) in osteosarcoma

Natural Products as Cytotoxic Agents

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