Viral warts (Human Papilloma Virus) as a potential risk for breast cancer among younger females

Atique, Suleman; Hsieh, Chung-Ho; Hsiao, Ruei-Ting; Iqbal, Usman; Nguyễn, Phụng Anh; Islam, Mohaimenul; Li, Yu-Chuan; Hsu, Chien‐Yeh; Chuang, Ting-Wu; Syed-Abdul, Shabbir

doi:10.1016/j.cmpb.2017.03.024

Cited by 12 publications

(9 citation statements)

References 27 publications

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“…In a similar way, a study conducted in Rio de Janeiro with cervical cancer patients 25 have found low-risk types in tumour samples. Another study also indicated that women who develop viral warts are at a significantly higher risk of developing BC 26 ; low-risk HPV types are causal agents of genital warts 3 , 7 . In addition, a study conducted with oral cancer in 187 patients had also suggested that separating high- and low-risk groups based on the HPV status of other body parts might not be appropriate 27 .…”

Section: Discussionmentioning

confidence: 98%

Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence

Cavalcante

Pinheiro

Almeida

et al. 2018

Clinics

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OBJECTIVE:The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil.METHOD:One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region.RESULTS:Human papillomavirus DNA was detected in 51 (49.5%) breast carcinoma samples and 15 (15.8%) normal breast samples (p<0.0001). Human papillomavirus genotypes 6 and 11 were identified in 15.2% of all samples.CONCLUSIONS:The high frequency of human papillomavirus infection in breast cancer samples indicates a potential role of this virus in breast carcinogenesis in the studied participants.

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Section: Discussionmentioning

confidence: 98%

Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence

Cavalcante

Pinheiro

Almeida

et al. 2018

Clinics

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“…Similarly, HPV-associated cervical infections can precede the development of same type HPV-positive breast cancer in the same patient ( 169 ). In a recent study based on the Taiwan National Health Insurance data base, it was shown that women with viral warts were at a 23% higher risk of developing breast cancer when compared with women not diagnosed with viral warts ( 170 ). The viral warts were assumed to be associated with HPVs.…”

Section: High-risk Human Papilloma Viruses and Breast Cancermentioning

confidence: 99%

Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV)

Salmons²,

2018

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BackgroundAlthough the risk factors for breast cancer are well established, namely female gender, early menarche and late menopause plus the protective influence of early pregnancy, the underlying causes of breast cancer remain unknown. The development of substantial recent evidence indicates that a handful of viruses may have a role in breast cancer. These viruses are mouse mammary tumor virus (MMTV), bovine leukemia virus (BLV), human papilloma viruses (HPVs), and Epstein–Barr virus (EBV-also known as human herpes virus type 4). Each of these viruses has documented oncogenic potential. The aim of this review is to inform the scientific and general community about this recent evidence.The evidenceMMTV and human breast cancer—the evidence is detailed and comprehensive but cannot be regarded as conclusive. BLV and human breast cancer—the evidence is limited. However, in view of the emerging information about BLV in human breast cancer, it is prudent to encourage the elimination of BLV in cattle, particularly in the dairy industry. HPVs and breast cancer—the evidence is substantial but not conclusive. The availability of effective preventive vaccines is a major advantage and their use should be encouraged. EBV and breast cancer—the evidence is also substantial but not conclusive. Currently, there are no practical means of either prevention or treatment. Although there is evidence of genetic predisposition, and cancer in general is a culmination of events, there is no evidence that inherited genetic traits are causal.ConclusionThe influence of oncogenic viruses is currently the major plausible hypothesis for a direct cause of human breast cancer.

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“…In a retrospective study, Atique et al (2017) reported that the incidence of breast cancer was higher among 800,000 HPV-infected patients than among the non-HPV-infected population [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease

Maldonado-Rodríguez

Hernández-Barrales

Reyes-López

et al. 2022

CIMB

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Breast cancer is the leading cause of cancer death among women worldwide. Multiple extrinsic and intrinsic factors are associated with this disease’s development. Various research groups worldwide have reported the presence of human papillomavirus (HPV) DNA in samples of malignant breast tumors. Although its role in mammary carcinogenesis is not fully understood, it is known that the HPV genome, once inserted into host cells, has oncogenic capabilities. The present study aimed to detect the presence of HPV DNA in 116 breast tissue biopsies and classify them according to their histology. It was found that 50.9% of the breast biopsies analyzed were malignant neoplasms, of which 74.6% were histologically classified as infiltrating ductal carcinoma. In biopsies with non-malignant breast disease, fibroadenoma was the most common benign neoplasm (39.1%). Detection of HPV DNA was performed through nested PCR using the external primer MY09/11 and the internal primer GP5+/6+. A hybridization assay genotyped HPV. HPV DNA was identified in 20.3% (12/59) of malignant neoplasms and 35% non-malignant breast disease (16/46). It was also detected in 27.3% (3/11) of breast tissue biopsies without alteration. However, there are no statistically significant differences between these groups and the existence of HPV DNA (p = 0.2521). Its presence was more frequent in non-malignant alterations than in malignant neoplasias. The most frequent genotypes in the HPV-positive samples were low-risk (LR) HPV-42 followed by high-risk (HR) HPV-31.

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Viral warts (Human Papilloma Virus) as a potential risk for breast cancer among younger females

Cited by 12 publications

References 27 publications

Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence

Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence

Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein–Barr Virus (EBV)

Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease

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