Viral zoonoses in Europe

Kallio‐Kokko, Hannimari; Uzcátegui, Nathalie Y.; Vapalahti, Olli; Vaheri, Antti

doi:10.1016/j.femsre.2005.04.012

Cited by 59 publications

(49 citation statements)

References 214 publications

(240 reference statements)

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“…9,[24][25][26][27][28] Several transmissible agents, from animal origin, either bacterial or viral, can cause zoonotic diseases in humans. 2,29 However, only a few papers have evaluated the association between contact with livestock and subsequent risk of lymphoma; most findings of an increased risk were related to contact with cattle or swine, [9][10][11] whilst a reduced risk was reported with contact with sheep or poultry, rabbits and hare. 10 We are not aware of previous publications exploring the risk of non-Hodgkin lymphoma or any other lymphoma type or subtype, analyzed by age at onset of occupational contact with livestock.…”

Section: Discussionmentioning

confidence: 99%

Lymphoma risk in livestock farmers: Results of the Epilymph study

Cocco

Satta

D’Andrea

et al. 2012

Intl Journal of Cancer

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We explored the risk of lymphoma and its most prevalent subtypes associated with occupational contact with livestock, and whether risk was modified by age at first contact, in 2,348 incident lymphoma cases and 2,462 controls who participated in the EPILYMPH case-control study. A detailed occupational history was collected in cases and controls, including working in a livestock farm, species of livestock, its approximate number and circumstances of contact. For each disease outcome, and each type of livestock, odds ratios (OR) and their 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for age, gender, education and center. Lymphoma risk (all subtypes combined) was not increased amongst those exposed to contact with any livestock (OR 5 1.0, 95% CI 0.8-1.2). Overall, we did not observe an association between occupational contact with livestock and risk of lymphoma (all types) and B-cell lymphoma. The risk of diffuse large B cell lyphoma (DLBCL) was significantly lower amongst subjects who started occupational contact with any species of livestock before or at age 12 (OR 5 0.5, 95% CI 0.2-0.9), but not at older ages. A significant heterogeneity in risk of B cell lymphoma by age at first contact was detected for contact with cattle, poultry and swine. Early occupational contact with livestock might be associated with a decrease in risk of B cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Lymphoma risk in livestock farmers: Results of the Epilymph study

Cocco

Satta

D’Andrea

et al. 2012

Intl Journal of Cancer

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“…The best-known rodent-borne zoonotic viruses in Europe include hantaviruses, lymphocytic choriomeningitis virus (LCMV), Ljungan virus (LV), and cowpox virus (CPXV) (Kallio-Kokko et al 2005, Jääskeläinen et al 2013, Vaheri et al 2013. No human-to-human transmission has been identified for these viruses (except for LCMV infections associated with organ transplantation; Fischer et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Food resources and intestinal parasites as limiting factors for boreal vole populations during winter

Forbes

Stuart

Mappes

et al. 2014

Ecology

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Processes limiting the growth of cyclic vole populations have stimulated considerable research and debate over several decades. In Fennoscandia, the peak density of cyclic vole populations occurs in fall, and is followed by a severe winter decline. Food availability and intestinal parasites have been demonstrated to independently and synergistically limit wildlife populations. The purpose of this study was to directly compare competing food and parasite hypotheses on the limitation of overwintering high‐density vole populations. Moreover, we evaluated the ability of food limitation and nematode infection to interact and thereby intensify population declines. A two‐factor experiment with food supplementation and antihelminthic medication was conducted on replicated, enclosed field vole (Microtus agrestis) populations in central Finland over one full boreal winter. Population abundance, survival, and demographic attributes were monitored through live trapping. Vole feces were concurrently examined for the eggs of Heligmosomidae nemadotes and oocysts of eimerian coccidians. We found that vole density declined in all treatment groups throughout winter. However, food supplementation mitigated this decline through positive effects on reproduction, and voles in food‐supplemented populations were generally in better physiological condition than non‐supplemented voles. Food supplementation and antihelminthic treatment reduced the prevalence of Heligmosomidae nematodes, while neither food nor medication affected the prevalence of eimerians, or infection intensity of either parasite group. Although food supplementation and antihelminthic medication aided in the clearance of Heligmosomidae nematodes, their prevalence did not influence vole population growth, and this parasite group is therefore unlikely to contribute to the cyclic winter decline of boreal vole populations. Instead food resources acting alone were the primary factor limiting vole population growth.

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“…Saaremaa virus (SAAV), first isolated in Estonia and found also in Russia, Slovenia and Germany, is genetically closely related to DOBV but causes a mild form of HFRS [8,9]. Although other hantaviruses have been isolated in Germany, hantavirus infections in central Europe are generally caused by PUUV [10,11].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of hantavirus infections in Switzerland in 2009: difficulties in determining prevalence in a country with low endemicity

et al. 2013

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In several European countries, diagnosis of nephropathia epidemica, a mild form of haemorrhagic fever with renal syndrome (HFRS) caused by Puumalavirus infection, has increased over the past 10-20 years. In Switzerland, despite its geographical proximity to regions with epidemic outbreaks in Germany and France, infections are detected only sporadically. To estimate the actual prevalence and potential risk factors of human hantavirus infections in Switzerland, a seroepidemiological study was performed in 2009 on serum samples from 4,559 blood donors and 1,810 military personnel. Sera were screened using commercial Puumala IgG and hantavirus IgG enzyme-linked immunosorbent assays indicating a seroprevalence of 1% and 9%, respectively. Subsequently, the samples were analysed by immunofluorescence assay and immunoblot assay, showing a much lower prevalence, of 0.4% and 0.3%, respectively. Two of the serum samples achieved an 80% reduction in plaque-forming units in a neutralisation test. Statistical evaluation of questionnaires only identified an association of age (above 50 years) with hantavirus seropositivity when adjusted for sex (odds ratio: 2.36; 95% confidence interval: 1.10-5.05). This study provides baseline data (0.3-0.4%) for future monitoring of hantavirus seroprevalence in Switzerland and highlights the challenges in estimating the seroprevalence of these viruses in a country with very low endemicity.

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Viral zoonoses in Europe

Cited by 59 publications

References 214 publications

Lymphoma risk in livestock farmers: Results of the Epilymph study

Lymphoma risk in livestock farmers: Results of the Epilymph study

Food resources and intestinal parasites as limiting factors for boreal vole populations during winter

Seroprevalence of hantavirus infections in Switzerland in 2009: difficulties in determining prevalence in a country with low endemicity

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