Viren als immunologische Adjuvantien f�r die Produktion von Antik�rpern gegen Wirtszellantigene

Bandlow, G.; Kieling, F.; Thomssen, R.

doi:10.1007/bf01242974

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1972

1976

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Cited by 7 publications

(2 citation statements)

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“…Eine Steigerung der immunogenen }Virkung heterologer Zellen dureh virusinduzierte Membranantigene ist mehrfaeh besehrieben worden (2,3,4,5,8). So beriehten u. a. BAXDLOW et al (2,3,4) (1) gesehert werdem Sic a.pplizierten Kaninchen intraartikulgr tIerpesvirem Es entwickelte sich eine chronische Arthritis im kontrMateralen Knie, die histologisch der rheuraatoiden Arthritis i~hnlich war.…”

Section: Diskussionunclassified

Herpesvirus-induced autoantibodies in animals

Wutzler

Färber

Sprössig

et al. 1976

Archives of Virology

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Section: Diskussionunclassified

Herpesvirus-induced autoantibodies in animals

Wutzler

Färber

Sprössig

et al. 1976

Archives of Virology

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“…In preceding papers we have reported that viruses act as immunological adjuvants (2). Guinea pigs being actively immunized against heterologous virusinfected cells showed an increased production of humoral antibodies against the host cells used.…”

Section: Introductionmentioning

confidence: 99%

Increased cellular immunity against host cell antigens induced by vacciniavirus

Bandlow

Koszinowski

1974

Archiv f Virusforschung

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The exclusive copyright for all languages and countries, including the right for photomechanical and any other reproductions including microform is transferred to the publisher. SummaryGuinea pigs show an increased cell-mediated immunity against host cell antigens after active immunization with vaccinia virus infected tissue culture cells. This immunologic adjuvant effect was observed in a heterologous system comprising primary rabbit kidney cells, primary fibroblasts from the mouse, permanent monkey kidney cells and in vivo infected mouse brain cells. The quantitative determination of the cellular immune response was carried out both in macrophage migration inhibition and in lymphocyte transformation tests. Cell-mediated immunity appears on the third day after immunization. A prerequisite for the adjuvant effect is the reproduction of the virus in the cell against which the increased cell-mediated immune response is directed.

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