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ZusammenlassungMonolayerkulturen yon prim/~ren M/~usefibroblasten werden mit Myxovirus parainfluenza 1 (Sendal) infiziert. W~thrend der Virusvermehrung wird homologes Sendai-Immunserum und Komplement zugefiigt. An den infizierten Zellen k6nnen dann parallel zum Auftreten h/~madsorbierender Oberfl~chenantigene immuneytotoxisehe Reaktionen beobaehtet werden. Cytotoxieit/ttsparameter sin d die Freisetzung von Laktatdehydrogenase nnd von 3H naeh Markierung der Zellen mit 3H-Uridin. Die immuncytotoxisehe Aktivit/tt, die in den IgM-und IgG-Fraktionen lokalisiert ist, 1/igt sieh dutch Sendal-Virus absorbieren. SummaryCytotoxic Reactions on Cells Infected with Sendal Virus Monolayer cultures of primary mouse fibroblasts were infected with parainfluenza-1 (Sendal) virus. During virus replication homologous Sendal-immuneserum and complement were added. On infected cells immunocytotoxic reactions could be observed as soon as hemadsorbing surface antigens were appearing. Parameters of cytotoxicity were the liberation of lactic dehydrogenase and the ~H-release after labeling the cells with 3H-uridine. The immunocytotoxic activity localized in the IgM and IgG fractions could be absorbed by Sendal virus.

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