Virtual Angioscopy Using 3-Dimensional Rotational Digital Subtraction Angiography for Endovascular Assessment

Unno, Naoki; Mitsuoka, Hiroshi; Takei, Yasutaka; Igarashi, Tatsuya; Uchiyama, Takashi; Yamamoto, Naoto; Saito, Takaaki

doi:10.1177/152660280200900423

Cited by 17 publications

(4 citation statements)

References 14 publications

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“…Other invasive approaches, ie, elastography, 2 angioscopy, 3 thermography, 4 and intravascular ultrasound, 5,6 are designed to characterize late-stage vascular disease. In contrast, magnetic resonance imaging (MRI) offers a unique, noninvasive opportunity for sensitive detection and characterization of atherosclerotic disease.…”

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confidence: 99%

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles

et al. 2003

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Background-Angiogenesis is a critical feature of plaque development in atherosclerosis and might play a key role in both the initiation and later rupture of plaques that lead to myocardial infarction and stroke. The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to plaque instability, however, cannot be detected directly with any current diagnostic modality. Methods and Results-Atherosclerosis was induced in New Zealand White rabbits fed 1% cholesterol for Ϸ80 days.␣ v ␤ 3 -Integrin-targeted, paramagnetic nanoparticles were injected intravenously and provided specific detection of the neovasculature within 2 hours by routine magnetic resonance imaging (MRI) at a clinically relevant field strength (1.5 T). Increased angiogenesis was detected as a 47Ϯ5% enhancement in MRI signal averaged throughout the abdominal aortic wall among rabbits that received ␣ v ␤ 3 -targeted, paramagnetic nanoparticles. Pretreatment of atherosclerotic rabbits with ␣ v ␤ 3 -targeted, nonparamagnetic nanoparticles competitively blocked specific contrast enhancement of the ␣ v ␤ 3 -targeted paramagnetic agent. MRI revealed a pattern of increased ␣ v ␤ 3 -integrin distribution within the atherosclerotic wall that was spatially heterogeneous along both transverse and longitudinal planes of the abdominal aorta. Histology and immunohistochemistry confirmed marked proliferation of angiogenic vessels within the aortic adventitia, coincident with prominent, neointimal proliferation among cholesterol-fed, atherosclerotic rabbits in comparison with sparse incidence of neovasculature in the control animals. Conclusions-This molecular imaging approach might provide a method for defining the burden and evolution of atherosclerosis in susceptible individuals as well as responsiveness of individual patients to antiatherosclerotic therapies.

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confidence: 99%

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles

et al. 2003

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“…Virtual cisternoscopy was the fi rst described in the clinically relevant use of virtual endoscopy to achieve fl ythrough non-invasive imaging of the intracranial anatomic structures and vasculature topography [7] . Virtual endoscopic angioscopy is a new technique for the visualization of the internal surface of the vasculatures and aneurysms that allows fl ythrough views of the occlusive vascular pathology including the aneurysm orifi ce, intra-aneurysmal thrombi, and aneurysm wall calcifi cations [2,4,17] . Although such techniques are being increasingly used for preoperative evaluations they are rarely employed in perioperative procedures.…”

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confidence: 99%

Virtual Endoscope-Assisted Intracranial Aneurysm Surgery: Evaluation of Fifty-Eight Surgical Cases

Me¹,

Şekerci²,

Çakmakçı³

et al. 2007

Minim Invasive Neurosurg

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“…47 Although virtual angioscopic images acquired from angiographic data may help detect and classify endoleaks, this technique is still invasive compared to CT-VIE or MR-VIE. 48 Armerding et al 47 found no advantage of postprocedural DSA over CTA in the detection of postdeployment complications.…”

Section: Digital Subtraction Angiography (Dsa)mentioning

confidence: 99%

Transrenal Fixation of Aortic Stent-Grafts:Current Status and Future Directions

Sun

2004

Journal of Endovascular Therapy

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Aortic stent-graft repair has been widely used in clinical practice for more than a decade, achieving satisfactory results compared to open surgical techniques. Transrenal fixation of stent-grafts is designed to obtain secure fixation of the proximal end of the stent-graft to avoid graft migration and to prevent type I endoleak. Unlike infrarenal deployment of stent-grafts, transrenal fixation takes advantage of the relative stability of the suprarenal aorta as a landing zone for the uncovered struts of the proximal stent. These transostial wires have sparked concern about the patency of the renal arteries, interference with renal blood flow, and effects on renal function. Although short to midterm results with suprarenal stent-grafts have not shown significant changes in renal function, long-term effects of this technique are still not fully understood. This review will explore the current status of transrenal fixation of aortic stent-grafts, potential risks of stent struts relative to the renal ostium, alternative methods to preserve blood flow to the renal arteries, and future directions or developments in stent-graft design to prevent myointimal proliferation around the stent struts.

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Virtual Angioscopy Using 3-Dimensional Rotational Digital Subtraction Angiography for Endovascular Assessment

Cited by 17 publications

References 14 publications

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles

Virtual Endoscope-Assisted Intracranial Aneurysm Surgery: Evaluation of Fifty-Eight Surgical Cases

Transrenal Fixation of Aortic Stent-Grafts:Current Status and Future Directions

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Virtual Angioscopy Using 3-Dimensional Rotational Digital Subtraction Angiography for Endovascular Assessment

Cited by 17 publications

References 14 publications

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α v β 3 -Integrin–Targeted Nanoparticles

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α v β 3 -Integrin–Targeted Nanoparticles

Virtual Endoscope-Assisted Intracranial Aneurysm Surgery: Evaluation of Fifty-Eight Surgical Cases

Transrenal Fixation of Aortic Stent-Grafts:Current Status and Future Directions

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Product

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Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles