Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection

Li, Kangli; Wang, Congcong; Yang, Fan; Cao, Weijun; Zhu, Zixiang; Zheng, Haixue

doi:10.3389/fimmu.2021.571509

Cited by 37 publications

(33 citation statements)

References 210 publications

(241 reference statements)

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“…αvβ6 is highly expressed in the epithelial cells of FMDV target tissues. This is also consistent with the fact that FMDV frequently targets epithelial cells during infection [ 125 ]. The reported FMDV receptors include, in addition to the integrin receptors, the heparan sulfate (HS) receptor and a third receptor that has not been yet identified [ 126 ].…”

Section: Challenges and Obstacles In Bovine Embryo-maternal Communica...supporting

confidence: 89%

Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model

Calle

Ramírez

2022

Cells

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Bovine mesenchymal stem cells are a relevant cell population found in the maternal reproductive tract that exhibits the immunomodulation capacity required to prevent embryo rejection. The phenotypic plasticity showed by both endometrial mesenchymal stem cells (eMSC) and embryonic trophoblast through mesenchymal to epithelial transition and epithelial to mesenchymal transition, respectively, is essential for embryo implantation. Embryonic trophoblast maintains active crosstalk via EVs and soluble proteins with eMSC and peripheral blood MSC (pbMSC) to ensure the retention of eMSC in case of pregnancy and induce the chemotaxis of pbMSC, critical for successful implantation. Early pregnancy-related proteins and angiogenic markers are detected as cargo in EVs and the soluble fraction of the embryonic trophectoderm secretome. The pattern of protein secretion in trophectoderm-EVs changes depending on their epithelial or mesenchymal phenotype and due to the uptake of MSC EVs. However, the changes in this EV-mediated communication between maternal and embryonic MSC populations infected by viruses that cause abortions in cattle are poorly understood. They are critical in the investigation of reproductive viral pathologies.

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Section: Challenges and Obstacles In Bovine Embryo-maternal Communica...supporting

confidence: 89%

Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model

Calle

Ramírez

2022

Cells

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“…FMDV spreading can occur in an extremely rapid manner for a variety of reasons, including the small amount of virus required to initiate infection, the large amount of virus excreted by affected animals, and the multiple routes of infection [ 26 , 35 ]. Additionally, the rate by which a population of viruses, including the FMDV, evolves can be influenced by genomic mutation rates, genomic architecture, and the speed of replication and recombination.…”

Section: Discussionmentioning

confidence: 99%

Fibroblast growth factor 11 inhibits foot-and-mouth disease virus gene expression and replication <i>in vitro</i>

Kang

Seong

Yim

et al. 2022

The Journal of Veterinary Medical Science

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Foot-and-mouth disease virus (FMDV) causes highly contagious disease of cloven-hoofed animals such as cattle, swine, and sheep. Although FMD vaccine is the traditional way to protect against the disease, the use of FMD vaccines to protect early infection is limited. The alternative strategy of applying antiviral agents is required to control the spread of FMDV in outbreak situations. Fibroblast growth factor 11 (FGF11) is a member of the intracellular FGF. Here, we identified the inhibitory effect of FGF11 on FMDV gene expression through the transcriptional and translational regulation. For the quantitative analysis of FMDV transcription/translation level, we firstly constructed a plasmid reporter system (FMDV five prime untranslated region (5′ UTR) -luci) conjugating luciferase encoding gene with FMDV 5′ UTR region, which is a non-coding region to control FMDV transcription/translation and includes cis-acting replication element (CRE) and internal ribosome entry site (IRES). FGF11 decreased the gene expression of FMDV 5′ UTR-luci reporter in a dose-dependent manner. We further confirmed the inhibitory function of FGF11 on FMDV gene expression a replication in the FMDV-infected pig cells. FGF11 expression inhibited RNA production of FMDV RNA polymerase 3D gene in the FMDV-infected cells. In addition, while FMDV cell infection induced cytopathic effect (CPE) within 24 hr, FGF11 expression dramatically repressed CPE at the basal level. These results indicate that FGF11 inhibits FMDV gene expression and replication in vitro , implicating to provide intervention strategy for FMDV pathogenesis and transmission.

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“…Thus, the mechanisms involved with inflammation need additional investigation. Human rhinovirus, encephalomyocarditis virus, and foot‐and‐mouth disease virus (FMDV) are (+) ssRNA viruses belonging to the Picornaviridae family and the Enterovirus genus, Cardiovirus genus, and Aphthous genus, respectively 62 . They are all picornavirus that causes general harm to humans.…”

Section: Picornaviruses That Induce Cell Pyroptosismentioning

confidence: 99%

“…Human rhinovirus, encephalomyocarditis virus, and foot-and-mouth disease virus (FMDV) are (+) ssRNA viruses belonging to the Picornaviridae family and the Enterovirus genus, Cardiovirus genus, and Aphthous genus, respectively. 62 They are all picornavirus that causes general harm to humans. There are few published reports that clearly delineate their relationship with cell pyroptosis.…”

Section: Other Picornavirusesmentioning

confidence: 99%

Cell pyroptosis in picornavirus and its potential for treating viral infection

Zheng

Zhuang

et al. 2022

Journal of Medical Virology

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Cell pyroptosis has received increased attention due to the associations between innate immunity and disease, and it has become a major focal point recently due to in‐depth studies of cancer. With increased research on pyroptosis, scientists have discovered that it has an essential role in viral infections, especially in the occurrence and development of some picornavirus infections. Many picornaviruses, including Coxsackievirus, a71 enterovirus, human rhinovirus, encephalomyocarditis virus, and foot‐and‐mouth disease virus induce pyroptosis to varying degrees. This review summarized the mechanisms by which these viruses induce cell pyroptosis, which can be an effective defense against pathogen infection. However, excessive inflammasome activation or pyroptosis also can damage the host's health or aggravate disease progression. Careful approaches that acknowledge this dual effect will aid in the exploration of picornavirus infections and the mechanisms that produce the inflammatory response. This information will promote the development of drugs that can inhibit cell pyroptosis and provide new avenues for future clinical treatment.

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Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection

Cited by 37 publications

References 210 publications

Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model

Mesenchymal Stem Cells in Embryo-Maternal Communication under Healthy Conditions or Viral Infections: Lessons from a Bovine Model

Fibroblast growth factor 11 inhibits foot-and-mouth disease virus gene expression and replication <i>in vitro</i>

Cell pyroptosis in picornavirus and its potential for treating viral infection

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