Viruses' Life History: Towards a Mechanistic Basis of a Trade-Off between Survival and Reproduction among Phages

Paepe, Marianne De; Taddéi, François

doi:10.1371/journal.pbio.0040193

Cited by 280 publications

(332 citation statements)

References 45 publications

Supporting

Mentioning

307

Contrasting

Unclassified

Order By: Relevance

“…For example, if prokaryote and virus abundances varied systematically with another environmental co-factor during a transect, then this would potentially influence the inferred relationship between virus and prokaryote abundances. In that same way, variation in environmental correlates, including temperature and incident ration, may directly modify virus life history traits [20,44]. Likewise, some of the marine survey datasets examined here constitute repeated measurements at the same location (e.g., at the Bermuda Atlantic Time-series Study (BATS)).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Re-examination of the relationship between marine virus and microbial cell abundances

et al. 2016

View full text Add to dashboard Cite

Marine viruses are critical drivers of ocean biogeochemistry and their abundances vary spatiotemporally in the global oceans, with upper estimates exceeding 10 8 per ml. Over many years, a consensus has emerged that virus abundances are typically 10-fold higher than prokaryote abundances. The use of a fixed-ratio suggests that the relationship between virus and prokaryote abundances is both predictable and linear. However, the true explanatory power of a linear relationship and its robustness across diverse ocean environments is unclear. Here, we compile 5671 prokaryote and virus abundance estimates from 25 distinct marine surveys to characterize the relationship between virus and prokaryote abundances. We find that the median virus-to-prokaryote ratio (VPR) is 10:1 and 16:1 in the near-and sub-surface oceans, respectively. Nonetheless, we observe substantial variation in the VPR and find either no or limited explanatory power using fixed-ratio models. Instead, virus abundances are better described as nonlinear, power-law functions of prokaryote abundances -particularly when considering relationships within distinct marine surveys. Estimated power-laws have scaling exponents that are typically less than 1, signifying that the VPR decreases with prokaryote density, rather than remaining fixed. The emergence of power-law scaling presents a challenge for mechanistic models seeking to understand the ecological causes and consequences of marine virusmicrobe interactions. Such power-law scaling also implies that efforts to average viral effects on microbial mortality and biogeochemical cycles using "representative" abundances or abundanceratios need to be refined if they are to be utilized to make quantitative predictions at regional or global ocean scales.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Cochlan et al [17], Hara et al [26], Paul et al [34,35], Wommack et al [58] 1995 Maranger and Bird [31] survey 22 Quebec lakes and collect literature from 14 studies [4, 5, 7, 17, 26-28, 34, 41, 51, 58] and report VBR higher in freshwater (20)(21)(22)(23)(24)(25) than marine systems (1-5).…”

mentioning

confidence: 99%

Re-examination of the relationship between marine virus and microbial cell abundances

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Given that our hypothesized functional dependence leaves α and θ fixed, pathogen generation length is then fixed, and we can take N as surrogate for multiplication rate. De Paepe and Taddei (2006) report that the logarithm of multiplication rate declines linearly in particle mass; the resulting approximation in our model's terms is N ≈ N max e −ϕm ; ϕ > 0. Since ϕ should depend on processes within host tissues, greater suppression of infection by the host should increase ϕ.…”

Section: Less Numerous More Persistent Particlesmentioning

confidence: 87%

“…Suppose that increasing the expected persistence time of FLP requires that a pathogen convert more host resources per particle produced (see De Paepe and Taddei, 2006). If shed rate and burst size remain constant, the pathogen must then accelerate consumption of the infected host's resources.…”

Section: Curse Of the Pharaohmentioning

confidence: 99%

Free-living pathogens: Life-history constraints and strain competition

Caraco

Wang

2008

Journal of Theoretical Biology

View full text Add to dashboard Cite

Many pathogen life histories include a free-living stage, often with anatomical and physiological adaptations promoting persistence outside of host tissues. More durable particles presumably require that the pathogen metabolize more resources per particle. Therefore, we hypothesize functional dependencies, pleiotropic constraints, between the rate at which free-living particles decay outside of host tissues and other pathogen traits, including virulence, the probability of infecting a host upon contact, and pathogen reproduction within host tissues. Assuming that pathogen strains compete for hosts preemptively, we find patterns in trait dependencies predicting whether or not strain competition favors a highly persistent free-living stage.

show abstract

“…1998, De Paepe and Taddei 2006) and consequently also among aquatic environments (Wommack and Colwell 2000, Weinbauer 2004, Parada et al. 2006) harboring different viral communities.…”

Section: Discussionmentioning

confidence: 99%

Mixing alters the lytic activity of viruses in the dark ocean

Winter

Köstner

Kruspe

et al. 2018

Ecology

View full text Add to dashboard Cite

In aquatic habitats, viral lysis of prokaryotic cells lowers the overall efficiency of the microbial loop, by which dissolved organic carbon is transfered to higher trophic levels. Mixing of water masses in the dark ocean occurs on a global scale and may have far reaching consequences for the different prokaryotic and virus communities found in these waters by altering the environmental conditions these communities experience. We hypothesize that mixing of deep ocean water masses enhances the lytic activity of viruses infecting prokaryotes. To address this hypothesis, major deep‐sea water masses of the Atlantic Ocean such as North Atlantic Deep Water, Mediterranean Sea Overflow Water, Antarctic Intermediate Water, and Antarctic Bottom Water were sampled at five locations. Prokaryotic cells from these samples were collected by filtration and subsequently incubated in virus‐reduced water from either the same (control) or a different water mass (transplantation treatment). Additionally, mixtures of prokaryotes obtained from two different water masses were incubated in a mixture of virus‐reduced water from the same water masses (control) or in virus‐reduced water from the source water masses separately (mixing treatments). Pronounced differences in productivity‐related parameters (prokaryotic leucine incorporation, prokaryotic and viral abundance) between water masses caused strong changes in viral lysis of prokaryotes. Often, mixing of water masses increased viral lysis of prokaryotes, indicating that lysogenic viruses were induced into the lytic cycle. Mixing‐induced changes in viral lysis had a strong effect on the community composition of prokaryotes and viruses. Our data show that mixing of deep‐sea water masses alters levels of viral lysis of prokaryotes and in many cases weakens the efficiency of the microbial loop by enhancing the recycling of organic carbon in the deep ocean.

show abstract

Viruses' Life History: Towards a Mechanistic Basis of a Trade-Off between Survival and Reproduction among Phages

Cited by 280 publications

References 45 publications

Re-examination of the relationship between marine virus and microbial cell abundances

Re-examination of the relationship between marine virus and microbial cell abundances

Free-living pathogens: Life-history constraints and strain competition

Mixing alters the lytic activity of viruses in the dark ocean

Contact Info

Product

Resources

About