Viscoelastic and optical properties of four different PDMS polymers

Deguchi, Shinji; Hotta, Junya; Yokoyama, Susumu; Matsui, Tsubasa S.

doi:10.1088/0960-1317/25/9/097002

Cited by 52 publications

(28 citation statements)

References 24 publications

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“…52 The Sylgard 184 PDMS material in the commercial vessel tubing absorbs and scatters light minimally (µ a ∼ µ ′ s ∼ 0 cm −1 ). 53 The refractive index of Sylgard 184 PDMS is 1.40, which is comparable to that soft tissue (1.36-1.44). 23 Thus it can be assumed that the vessels are optically transparent within the phantoms.…”

Section: B2 Optical Properties Of Phantom Vesselsmentioning

confidence: 92%

Multilayered tissue mimicking skin and vessel phantoms with tunable mechanical, optical, and acoustic properties

et al. 2016

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Section: B2 Optical Properties Of Phantom Vesselsmentioning

confidence: 92%

Multilayered tissue mimicking skin and vessel phantoms with tunable mechanical, optical, and acoustic properties

et al. 2016

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“…38 PDMS displays a high refractive index of >1.40 and optical transparency. 38 PDMS displays a high refractive index of >1.40 and optical transparency.…”

Section: Fabrication Of Bioengineered Eggshellmentioning

confidence: 99%

“…[33][34][35][36][37] PDMS possesses favorable unique properties as it is permeable to gases, chemically inert, thermally stable, rigid, and optically clear. [38][39][40][41] Lai and Liu 32 and Huang et al 30 have fabricated cubic eggshells made of PDMS with an internal egg-shaped feature in the former model but not in the latter. Huang et al 31 further developed the cubic eggshell to have the ability to direct blood vessel formation.…”

Section: Glass Bowl Glass Bowl With Clear Lid Angiogenesis and Vasculmentioning

confidence: 99%

“…PDMS, in particular Sylgard-184, was the material of choice to fabricate the bioengineered eggshell because of its optical properties and relatively clear appearance. 38 PDMS displays a high refractive index of >1.40 and optical transparency. 38 Its excellent moldability provides ease of fabrication true to the intended design.…”

Section: Fabrication Of Bioengineered Eggshellmentioning

confidence: 99%

“…38 PDMS displays a high refractive index of >1.40 and optical transparency. 38 Its excellent moldability provides ease of fabrication true to the intended design. It also possesses rigidity, 44 dependent on thickness, thus allowing handling.…”

Section: Fabrication Of Bioengineered Eggshellmentioning

confidence: 99%

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Bioengineered three‐dimensional transparent eggshell as a chicken embryo experimentation platform for biomedical research

Ishak

Chan

Ang

et al. 2020

Engineering Reports

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The chicken embryo is widely used as an experimental model in the areas of regenerative medicine, tumor biology, and angiogenesis. Eggshell opacity and rigidity present restricted three-dimensional (3D) viewing and accessibility to the embryo and its circulatory network despite egg windowing. The ability to engineer an eggshell, which eliminates the opacity yet provides 3D access for manipulation is beneficial and would potentially make it enticing for the use of chicken embryo as a cheaper alternative vertebrate model.Here, we present the feasibility of fabricating a morphologically analogous transparent chicken eggshell made of polydimethylsiloxane using a biaxial rotation computer-controlled bioreactor to achieve uniform thickness. By culturing chicken embryo in the bioengineered eggshell, we demonstrated success in meeting developmental milestones and its practicality as an experimental platform by visualizing both embryo and vasculature development using common laboratory imaging tools. Although the viability of the embryo in the bioengineered eggshell was lower than in the normal egg, this was attributed to the absence of calcium source. The bioengineered eggshell, in its initial stage of development, provides a platform to be used to investigate beyond gross observations of the embryo and vascular network in 3D optical clarity and its imaging capabilities has the potential to be extended to other imaging modalities. We have developed a transparent ex ovo eggshell, biomimicking the elliptical geometry to address the lack of 3D optical clarity contributed by the eggshell opacity.This retains the natural shape that may support the development of the chicken embryo and allows easy access to the embryo, its circulatory system and respective organ development in far reaching applications. K E Y W O R D Sbioengineering, chicken embryo, fabrication, imaging, rotation moldingThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.The use of chicken embryo as an experimental model confers several advantages over other vertebrate models. It is a unique model, which allows relatively easy access to the embryo and its circulatory system, rendering the possibility for embryo manipulation and monitoring of the chicken embryo development from blastoderm formation until hatching. The chicken embryo is an inexpensive model with a relatively short embryonic development of 21 days. 1,2 In addition, they are ethically acceptable, only requiring animal ethics approval if hatching is expected. Moreover, its amenability to xenografting due to its naturally immunodeficient system in the first 2 weeks of development allows cell transplantation and cell tracking without rejection, rendering it an attractive model widely used in tumor biology, angiogenesis, and regenerative medicine studies. 3-11 These embryo manipulations and visualizati...

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Ultrathin and Wearable Microtubular Epidermal Sensor for Real‐Time Physiological Pulse Monitoring

Yeo

et al. 2017

Adv Materials Technologies

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high performance of these sensors, their complicated structures, in many cases, require more expensive and complex production routes, limiting its scalability and reproducibility. [33] Conductive liquids belong to another class of materials suitable for deployment in soft and stretchable sensing platforms. These liquids assume the shape of the microchannels within the soft silicone elastomer due to the weak intermolecular forces of attraction between particles. As such, they are highly patternable and reconfigurable. [34][35][36] Recently, several liquid metals that exist in a fluid state in room temperatures are gaining popularity. Among which, Gallistan and eutectic gallium-indium (eGaIn) are two widely reported electrically conductive liquid metallic alloys that are nontoxic and highly deformable. [37] Microfluidic devices based on the liquid metals have therefore been increasingly employed as wearable pressure sensors, [38] strain sensors, [39] temperature sensors, [40] and even more recently as a thermotherapy platform. [41] However, the macroscopic monolithic film format of microfluidics may not fully meet the requirements of imperceptibility and affect conformability due to many subtle but nonflat topologies on the surface of human skin. Thus, an ultrasensitive tactile sensor that is ultrathin, ultralight, and shape configurable is highly desirable.Here, we report an ultrathin microtubular resistive sensor that is soft, flexible, stretchable, and simple to manufacture. The microtube facilitates the deployment of liquid metallic alloy eGaIn which serves as a thin flexible conduit with excellent electrical conductivity and mechanical deformability. Specifically, by considering the radius and thickness of the microtube, we realize an ultrasensitive liquid-based tactile sensor with high flexibility and durability. The self-sustaining fiber-like shape of the sensor is entirely conformal to human interfaces due to its ability to twist around 3D curvatures and objects. In addition, its tiny footprint of 120 µm in diameter makes it almost imperceptible when worn on bare skin. The results of this work establish an attractive option for imperceptible epidermal healthcare diagnostics and monitoring platform.To achieve sensitive force measurements, we utilize liquid metallic alloy within a tubular structure in a submillimeter regime. Liquid metal core fiber of ≈400 µm inner diameter and ≈100 µm in wall thickness has been previously demonstrated as a strain sensor. [42] However, in our current study, we developed a facile manufacturing strategy to achieve an ultrathin, soft core fiber that was previously unattainable. The fabrication process A flexible, stretchable, soft, and ultrathin wearable microtubular sensor that is highly sensitive to mechanical perturbations is developed. The sensor comprises a unique architecture consisting of a liquid-state conductive element core within a soft silicone elastomer microtube. The microtubular sensor can distinguish forces as small as 5 mN and possesses a high force sensitivity ...

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Viscoelastic and optical properties of four different PDMS polymers

Cited by 52 publications

References 24 publications

Multilayered tissue mimicking skin and vessel phantoms with tunable mechanical, optical, and acoustic properties

Multilayered tissue mimicking skin and vessel phantoms with tunable mechanical, optical, and acoustic properties

Bioengineered three‐dimensional transparent eggshell as a chicken embryo experimentation platform for biomedical research

Ultrathin and Wearable Microtubular Epidermal Sensor for Real‐Time Physiological Pulse Monitoring

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