Visible light-induced photocatalytic chlorine activation enhanced the 0.5% neutral-NaClO/TiO2-x system as an efficient and safe root canal irrigant

Super-Rapid In Situ Formation of a Silver Ion-Induced Supramolecular Hydrogel with Efficient Antibacterial Activity for Root Canal Disinfection

“…Therefore, the antimicrobial efficacies of the CH paste or Ag-isoG hydrogel in eliminating microorganisms from root canal walls and dentine tubules were compared using an in vitro root canal model infected with E. faecalis. 45,52 A schematic illustration of the application of the Ag-isoG hydrogel in root canal infection treatment is shown in Figure 5A.…”

“…faecalis . , A schematic illustration of the application of the Ag-isoG hydrogel in root canal infection treatment is shown in Figure A.…”

Surface-Confined Piezocatalysis Inspired by ROS Generation of Mitochondria Respiratory Chain for Ultrasound-Driven Noninvasive Elimination of Implant Infection

“…The polymer implants with piezoelectric surface, i.e., “piezoPolymer”, proposed in this paper has a wide range of potential applications and might be applied to many medical scenarios (Figure a), such as oral implants, bone grafts, urinary catheters, bioelectronics encapsulation, etc. For instance, when there are serious dental caries, wedge-shaped defects, trauma, and other damage to the pulp, it is necessary to carry out root canal therapy (RCT) to protect the tooth against future infection. − In traditional RCT, the infected or inflamed pulp is removed and the root canal space is typically filled with gutta-percha (GP), a trans -1,4-polyisoprene dominated nondegradable natural polymer isolated from the percha tree. However, there are still some teeth failure after RCT mainly due to bacteria regrowth in the leakage of GP and root canal. − Once the root canal reinfection occurs, the original filling must be taken out, and the root canal will be cleaned and reshaped and then refilled with new GP, which is both time-consuming and damaging to dental tissue (Figure b).…”

Near-Infrared-Enhanced Dual Enzyme-Mimicking Ag–TiO2–x@Alginate Microspheres with Antibactericidal and Oxygeneration Abilities to Treat Periodontitis

“…Titania (TiO 2 ) has many advantages such as excellent chemical stability, biocompatibility, and low cost, and it has been widely applied in biomedical fields. − TiO 2 is one of the most commonly used pharmaceutical excipients as white pigments or opacifiers, further indicating its biocompatibility and safety. Oxygen-deficient titania (TiO 2– x ), derived from TiO 2 via reduction treatment, possesses multiple properties including photocatalytic activity, POD-like catalytic activity, and photothermal property and their synergistic effects. − As a result, TiO 2– x has acquired greatly extended research interests in antitumor and antibacterial therapies with high efficiency. , Our previous studies demonstrated the near-infrared (NIR)-induced photothermally enhanced Fenton-like activity of nano-TiO 2– x , which can greatly activate H 2 O 2 to produce hydroxyl radicals ( • OH) for discolored-tooth bleaching . In this context, it is reasonable to speculate that TiO 2– x has excellent application potential in the construction of novel periodontal antibacterial systems.…”

“…31−33 As a result, TiO 2−x has acquired greatly extended research interests in antitumor and antibacterial therapies with high efficiency. 34,35 Our previous studies demonstrated the near-infrared (NIR)induced photothermally enhanced Fenton-like activity of nano-TiO 2−x , which can greatly activate H 2 O 2 to produce hydroxyl radicals ( • OH) for discolored-tooth bleaching. 36 In this context, it is reasonable to speculate that TiO 2−x has excellent application potential in the construction of novel periodontal antibacterial systems.…”