Visualization of cerebrospinal fluid flow in syringomyelia through noninvasive magnetic resonance imaging with a time-spatial labeling inversion pulse (Time-SLIP)

Takeuchi, Kazuhiro; Ono, Atsushi; Hashiguchi, Yusuke; Misawa, Haruo; Takahata, Tomohiro; Teramoto, Arubi

doi:10.1080/10790268.2016.1140391

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…In symptomatic patients with Chiari I, peak systolic velocity was significantly higher than those in control volunteers [ 15 ], and CSF flow was characterized by flow jets, regions with a preponderance of flow in one direction, and synchronous bidirectional flow [ 16 17 ]. Additionally, one recent case report confirmed the patterns and directional changes of CSF flow in syringomyelia by using Time-SLIP [ 18 ].…”

Section: Introductionmentioning

confidence: 85%

Cerebrospinal fluid flow in normal beagle dogs analyzed using magnetic resonance imaging

et al. 2021

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Background Diseases related to cerebrospinal fluid flow, such as hydrocephalus, syringomyelia, and Chiari malformation, are often found in small dogs. Although studies in human medicine have revealed a correlation with cerebrospinal fluid flow in these diseases by magnetic resonance imaging, there is little information and no standard data for normal dogs. Objectives The purpose of this study was to obtain cerebrospinal fluid flow velocity data from the cerebral aqueduct and subarachnoid space at the foramen magnum in healthy beagle dogs. Methods Six healthy beagle dogs were used in this experimental study. The dogs underwent phase-contrast and time-spatial labeling inversion pulse magnetic resonance imaging. Flow rate variations in the cerebrospinal fluid were observed using sagittal time-spatial labeling inversion pulse images. The pattern and velocity of cerebrospinal fluid flow were assessed using phase-contrast magnetic resonance imaging within the subarachnoid space at the foramen magnum level and the cerebral aqueduct. Results In the ventral aspect of the subarachnoid space and cerebral aqueduct, the cerebrospinal fluid was characterized by a bidirectional flow throughout the cardiac cycle. The mean ± SD peak velocities through the ventral and dorsal aspects of the subarachnoid space and the cerebral aqueduct were 1.39 ± 0.13, 0.32 ± 0.12, and 0.76 ± 0.43 cm/s, respectively. Conclusions Noninvasive visualization of cerebrospinal fluid flow movement with magnetic resonance imaging was feasible, and a reference dataset of cerebrospinal fluid flow peak velocities was obtained through the cervical subarachnoid space and cerebral aqueduct in healthy dogs.

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Section: Introductionmentioning

confidence: 85%

Cerebrospinal fluid flow in normal beagle dogs analyzed using magnetic resonance imaging

et al. 2021

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“…In this context, identifying leakage points with MRI is beneficial in reducing the risk. While successful application of T-SLIP MRI has recently been reported in cases of cystic lesions of the spinal cord or syringomyelia,[512] the present report appears to be one of the first to successfully utilize T-SLIP MRI in the evaluation of patients with SIH. Using this technique, we were able to diagnose with confidence that CSF leakage occurred at the C1-2 level without performing dynamic CT or digital subtraction myelography, thus avoiding additional radiation exposure in a woman of reproductive age.…”

Section: Discussionmentioning

confidence: 88%

“…Second, unlike dynamic CT myelography or digital subtraction myelography, T-SLIP MRI is not a real-time imaging modality, and at present, it can only be performed using MRI equipped with specific software. [512] The actual speed of CSF outflow is twice that shown in Supplementary video 2. Third, it was not possible to make any conclusions regarding the pathoetiology of the pouch observed intraoperatively, as no surgical specimen was obtained.…”

Section: Discussionmentioning

confidence: 92%

Application of time-spatial labeling inversion pulse magnetic resonance imaging in the diagnosis of spontaneous intracranial hypotension due to high-flow cerebrospinal fluid leakage at C1-2

et al. 2016

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Background:Spontaneous intracranial hypotension (SIH) due to cerebrospinal fluid (CSF) leakage at C1-2 poses diagnostic and therapeutic challenges to spine surgeons. Although computed tomography (CT) myelography has been the diagnostic imaging modality of choice for identifying the CSF leakage point, extradural CSF collection at C1-2 on conventional CT myelography or magnetic resonance imaging (MRI) may often be a false localizing sign.Case Description:The present study reports the successful application of time-spatial labeling inversion pulse (T-SLIP) MRI, which enabled the precise identification of the CSF leakage point at C1-2 in a 28-year-old woman with intractable SIH. After identifying the leakage point using both CT myelography and T-SLIP MRI, surgery was performed to seal the CSF leak. Intraoperatively, a pouch suggestive of an extradural arachnoid cyst around the left C2 nerve root was found, which was repaired by packing the pouch with muscle and fibrin glue. Clinical improvement was observed shortly after surgery, and postoperative imaging revealed the disappearance of the CSF leakage.Conclusions:T-SLIP MRI may provide useful information on the flow dynamics of CSF in SIH patients due to high-flow leakage. However, further experience is required to assess its sensitivity and specificity as an imaging modality for identifying CSF leakage points.

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“…Notably, Time-SLIP MRI has been highlighted in multiple studies for its non-invasive evaluation of CSF dynamics. Takeuchi et al applied Time-SLIP in a syringomyelia case, unveiling unique CSF flow patterns otherwise unseen with conventional imaging 20 . Ohtonari et al further emphasized the utility of Time-SLIP MRI in assessing combined ventral and dorsal CSF dynamics at the craniocervical junction in Chiari malformation type I patients 16 .…”

Section: Discussionmentioning

confidence: 99%

The significance of cerebrospinal fluid dynamics in adolescent idiopathic scoliosis using time-SLIP MRI

Tomita,

Yagi,

Seki

et al. 2024

Sci Rep

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Adolescent idiopathic scoliosis (AIS) affects approximately 3% of the global population. Recent studies have drawn attention to abnormalities in the dynamics of the CSF as potential contributors. This research aims to employ the Time-Spatial Labeling Inversion Pulse (Time-SLIP) MRI to assess and analyze cerebrospinal fluid (CSF) dynamics in AIS patients. 101 AIS patients underwent Time-SLIP MRI. Images were taken at the mid-cervical and craniocervical junction regions. The sum of the maximum movement distances of CSF on the ventral and dorsal sides of the spinal canal within a single timeframe was defined and measured as Travel Distance (TD). Correlations between TD, age, Cobb angle, and Risser grade were analyzed. TD comparisons were made across Lenke classifications. TD for all patients was a weak correlation with the Cobb angle (r = − 0.16). Comparing TD between Lenke type 1 and 5, type 5 patients display significantly shorter TD (p < 0.05). In Risser5 patients with Lenke type 5 showed a significant negative correlation between Cobb angle and TD (r = − 0.44). Lenke type 5 patients had significantly shorter CSF TD compared to type1, correlating with worsening Cobb angles. Further analysis and exploration are required to understand the mechanism of onset and progression.

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Visualization of cerebrospinal fluid flow in syringomyelia through noninvasive magnetic resonance imaging with a time-spatial labeling inversion pulse (Time-SLIP)

Cited by 9 publications

References 18 publications

Cerebrospinal fluid flow in normal beagle dogs analyzed using magnetic resonance imaging

Cerebrospinal fluid flow in normal beagle dogs analyzed using magnetic resonance imaging

Application of time-spatial labeling inversion pulse magnetic resonance imaging in the diagnosis of spontaneous intracranial hypotension due to high-flow cerebrospinal fluid leakage at C1-2

The significance of cerebrospinal fluid dynamics in adolescent idiopathic scoliosis using time-SLIP MRI

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