Vitamin A Toxicity and Its Effect on Liver Nucleic Acids, Protein and Lipids in the Chick

Squibb, Robert L.

doi:10.3382/ps.0421332

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…The data obtained support, in part, the view of Squibb ( 6 ) that animals receiving high dosages of vit. A showed a significant decrease in liver proteins.…”

Section: Sodium Mobilization In Tail Arterysupporting

confidence: 82%

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Respiratory Activities of Hypo- and Hypervitaminotic-A Rat Liver Homogenates

Seward

Vaughan

Hove

1964

Experimental Biology and Medicine

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Although the role of vitamin A in the visual process is now reasonably well understood, its mechanism of action in intermediary metabolism and particularly in structural integrity of various tissues is not clear. Many investigators have sought to learn more about thle function of vit. A through studies on the metabolic lesions elicited by a deficiency or an excess of the vitamin. Recently DeLuca et aZ( 1) showed an increase in oxygen uptake (measured for 30 min) by liver homogenates of vit. A-deficient rats with a number of Krebs cycle acids. Sampson and co-workers (2) demonstrated that most female rats receiving from 300-525 units of vit. A/g of body weight daily had higher respiratory quotients than litter mate controls. Redfern( 3) recorded an increase in endogenous oxidation by liver homogenates from vit. A-deficient rats. On the other hand, Ray and Sadhu(4) reported that liver slices and homogenates of rats fed excess vit. A, showed a significantly decreased oxidation of succinate. Berdjis(5) reported an increase in number of mast cells in almost all organs of rats given toxic doses of vit. A. They further stated that many pathological conditions and metabolic disturbances are directly related to the variations in mast cell population in tissues. Squibb (6) reported that chickens receiving 100,000 units of vit. A/day for 13 days showed a decrease in liver lipids. Brown et aZ ( 7) suggested that permeability changes associated with hypervitaminosis-A may be due to a change in sulfation of membraneassociated mucopolysaccharides, which appear to be necessary for the integrity of membrane structure.In this paper results are reported which show a marked initial elevation in oxygen uptake by liver homogenates from either hjrpovi tamino tic or hypervi taminotic-A rats. The initial increase in oxygen consumption is fo'llowed by a rapid decline during the follow-ing hour. An effect of tri-o-cresyl phospha.te (TCP) on respiratory control and liver lipids has also been demonstrated. This substance was studied because previous work( 10) had shown it to have a pro-oxidant action in unsaturated lipid systems in vitro, to decrease vit. A, and to produce changes in body fat composition in vivo.Materials and methods. Male weanling ratts of an Osborne-Mendel derived strain (FDA, Division of Nutrition) from dams maintained on a low vit. A stock diet were used in our deficiency studies. The basal diet contained 18% casein (vitamin free), 64% sucrose, 10% lard, 4% salt mixture (Jones-Foster), and 4% vitamin mixture (vit. A and E free). To this was added vit. E as a mixture of dl-alpha tocopherol and dl-alpha tocopherol acetate at 200 mg/kilo. Six weanling rats were used in each of 4 groups: They were fed 1) the basal diet, 2) basal diet supplemented with 5 mg of vit. A acetate per kilo, 3) basal diet with 0.1% TCP, and 4) b a d diet containing both vit. A and TCP. Vit. A deficiency was determined by the onset of loss in body weight, which occurred in 28-40 days. Food and water were available ad libitum. In our excess vit. A expe...

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“…The data obtained support, in part, the view of Squibb ( 6 ) that animals receiving high dosages of vit. A showed a significant decrease in liver proteins.…”

Section: Sodium Mobilization In Tail Arterysupporting

confidence: 82%

“…They further stated that many pathological conditions and metabolic disturbances are directly related to the variations in mast cell population in tissues. Squibb (6) reported that chickens receiving 100,000 units of vit. A/day for 13 days showed a decrease in liver lipids.…”

mentioning

confidence: 99%

Respiratory Activities of Hypo- and Hypervitaminotic-A Rat Liver Homogenates

Seward

Vaughan

Hove

1964

Experimental Biology and Medicine

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Vitamin A und Eiweiß

Rödel¹

1966

Nahrung

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In einer Übersicht werden die wechselseitigen Beziehungen zwischen Vitamin A und Eiweiß an Hand der jüngeren Literatur dargelegt. Im einzelnen werden folgende Themen behandelt: Vitamin‐A‐Bedarf und Eiweißversorgung, Resorption und Speicherung des Vitamin A in Abhängigkeit von der Eiweißversorgung, Carotinausnutzung und Eiweißversorgung, Bindung von Vitamin A und Carotin an Proteine, Einfluß von Vitamin A auf den Eiweißstoffwechsel.

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The influence of vitamin A status on the response of chickens to aflatoxin B₁and changes in liver lipid metabolism associated with aflatoxicosis

1979

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I A series of experiments were conducted to investigate the effects of dietary retinol status on chickens ingesting aflatoxin B,. The effects of dietary supplementation with biotin and a-tocopherol were also examined.2. Aflatoxin B, levels greater than I mg/kg diet had a detrimental effect on 'liveability', body-weight gain, food intake and food conversion efficiency. When fed for more than 2 weeks aflatoxin increased relative liver weight and liver lipid concentration. These effects were less pronounced with avitaminotic A chickens.3. A synergistic effect on hydropericardium development was observed between aflatoxin B, and retinol. This effect was not observed when the dietary level of a-tocopherol was increased tenfold.4. The specific activities of certain hepatic lipogenic and amino acid-metabolizing enzymes were influenced by aflatoxin ingestion. A reduction in lipogenic enzyme activity was observed before a reduction in the activities of amino acid-metabolizing enzymes.5. Liver fatty acid composition was significantly influenced by aflatoxin B,. The extent of these changes was reduced by the inclusion of additional dietary biotin.

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Vitamin A Toxicity and Its Effect on Liver Nucleic Acids, Protein and Lipids in the Chick

Cited by 7 publications

References 8 publications

Respiratory Activities of Hypo- and Hypervitaminotic-A Rat Liver Homogenates

Respiratory Activities of Hypo- and Hypervitaminotic-A Rat Liver Homogenates

Vitamin A und Eiweiß

The influence of vitamin A status on the response of chickens to aflatoxin B₁and changes in liver lipid metabolism associated with aflatoxicosis

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Vitamin A Toxicity and Its Effect on Liver Nucleic Acids, Protein and Lipids in the Chick

Cited by 7 publications

References 8 publications

Respiratory Activities of Hypo- and Hypervitaminotic-A Rat Liver Homogenates

Respiratory Activities of Hypo- and Hypervitaminotic-A Rat Liver Homogenates

Vitamin A und Eiweiß

The influence of vitamin A status on the response of chickens to aflatoxin B1and changes in liver lipid metabolism associated with aflatoxicosis

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The influence of vitamin A status on the response of chickens to aflatoxin B₁and changes in liver lipid metabolism associated with aflatoxicosis