Vitamin B12 and Folate Levels During Pregnancy and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Wang, Li; Hou, Yanping; Meng, Dexia; Li, Yang; Meng, Xiang; Liu, Feng

doi:10.3389/fnut.2021.670289

Cited by 13 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most notably, genes in the one carbon pool by folate pathway were significantly down-regulated in placentas and umbilical cord bloods, indicating that both pregnant women and fetuses with GDM may have the characteristics of folate deficiency. However, a meta-analysis regarding to the correlation between folic acid and the pathogenesis of GDM provides controversial results [ 57 ]. Larger cohort studies are necessary to explore the correlations.…”

Section: Resultsmentioning

confidence: 99%

DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring

Wang

Kakongoma

et al. 2022

Clin Epigenet

View full text Add to dashboard Cite

Background Gestational diabetes mellitus (GDM) is a common pregnancy-specific disease and is growing at an alarming rate worldwide, which can negatively affect the health of pregnant women and fetuses. However, most studies are limited to one tissue, placenta or umbilical cord blood, usually with one omics assay. It is thus difficult to systematically reveal the molecular mechanism of GDM and the key influencing factors on pregnant women and offspring. Results We recruited a group of 21 pregnant women with GDM and 20 controls without GDM. For each pregnant woman, reduced representation bisulfite sequencing and RNA-seq were performed using the placenta and paired neonatal umbilical cord blood specimens. Differentially methylated regions (DMRs) and differentially expressed genes (DEGs) were identified with body mass index as a covariate. Through the comparison of GDM and control samples, 2779 and 141 DMRs, 1442 and 488 DEGs were identified from placenta and umbilical cord blood, respectively. Functional enrichment analysis showed that the placenta methylation and expression profiles of GDM women mirrored the molecular characteristics of “type II diabetes” and “insulin resistance.” Methylation-altered genes in umbilical cord blood were associated with pathways “type II diabetes” and “cholesterol metabolism.” Remarkably, both DMRs and DEGs illustrated significant overlaps among placenta and umbilical cord blood samples. The overlapping DMRs were associated with “cholesterol metabolism.” The top-ranking pathways enriched in the shared DEGs include “growth hormone synthesis, secretion and action” and “type II diabetes mellitus.” Conclusions Our research demonstrated the epigenetic and transcriptomic alternations of GDM women and offspring. Our findings emphasized the importance of epigenetic modifications in the communication between pregnant women with GDM and offspring, and provided a reference for the prevention, control, treatment, and intervention of perinatal deleterious events of GDM and neonatal complications.

show abstract

Section: Resultsmentioning

confidence: 99%

DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring

Wang

Kakongoma

et al. 2022

Clin Epigenet

View full text Add to dashboard Cite

show abstract

“…For example, lack of available studies, a relatively small number of studies was included in this meta-analysis. Furthermore, the latest meta-analysis indicated that the association between the risk of GDM and vitamin B12 deficiency is conflicting [ 29 ], and the conclusion was derived from descriptive analysis which does not allow to draw safe conclusions. Due to these contradictory results, we conducted this updated analysis that included all published observational studies to clarify the potential link between vitamin B12 levels and imbalance of serum folic acid and vitamin B12 to the risk of GDM.…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, the findings of existing meta-analyses and systematic reviews are contradictory, and the significance of the folic acid/vitamin B12 in the risk of GDM remains unknown. A negative link was detected in 1 systematic review; however, it was based on just two publications with tiny samples [ 28 ]; the other systematic review was irrelevant as it included three completely different studies [ 29 ] and the most recent has shown that higher plasma/serum folic acid may increase GDM risk but with a low grade of quality.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B12 status and folic acid/vitamin B12 related to the risk of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of observational studies

Jiang

Cui

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background This review was conducted to investigate the association between serum vitamin B12 levels as well as folic acid/vitamin B12 during pregnancy and the risk of gestational diabetes mellitus (GDM). Methods A comprehensive search of electronic databases (Embase, PubMed, and Web of Science) was performed. The odds ratios (ORs) with 95% confidence intervals (CIs) of GDM risk were summarized using a random effects model. We also performed subgroup analyses to explore the source of heterogeneity. Results A total of 10 studies, including 10,595 pregnant women were assessed. Women with vitamin B12 deficiency were at higher risk for developing GDM when compared with those who were vitamin B12 sufficient (OR, 1.46; 95% CI 1.21–1.79; I2: 59.0%). Subgroup analysis indicated that this association might differ based on sample size and geographical distribution. Elevated vitamin B12 levels may decrease the risk of GDM by 23%. The role of excess folic acid and low vitamin B12 levels in the occurrence of GDM is also controversial. Conclusion In summary, vitamin B12 deficiency is associated with increased risk of GDM, it is necessary to pay more attention to the balance of vitamin B12 and folic acid. However, more in-depth studies across multiple populations are needed to verify these results.

show abstract

“…The levels of these two biomarkers were significantly and inversely correlated in our population (r = −0.087, p < 0.05). The ratio of folic acid/vitamin B 12 and GDM risk has been investigated in several studies [ 15 , 16 , 17 ] and analyzed in a meta-analysis [ 47 ]. Nevertheless, these studies have yielded contradictory results with negative, positive and no link detected.…”

Section: Discussionmentioning

confidence: 99%

The Association between Maternal B Vitamins in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study

Wang

et al. 2022

Nutrients

View full text Add to dashboard Cite

Background: This study evaluated the association between maternal B vitamins in early pregnancy and gestational diabetes mellitus (GDM) risk. Methods: A cohort of 1265 pregnant women was recruited at 8–15 weeks of gestation in 2021–2022 (Shanghai, China). Pregnancies with both serum B vitamin measurements at recruitment and glucose measurements at 24–28 weeks of gestation were included in the final analysis. Results: Of the 1065 pregnancies, in the final analysis, GDM occurred in 121 women (11.36%). In multivariate logistic models, an increased risk trend across serum vitamin B1 quartiles with GDM was observed (p-Trend = 0.001). Compared with women in the lowest quartile of serum vitamin B6, those in the upper two quartiles had approximately twofold higher odds of GDM. Moreover, compared with women with vitamin B12 levels < 150 pmol/L, those with vitamin B12 levels > 150 pmol/L had lower odds of GDM (p = 0.005). The restricted cubic spline regression models also revealed that serum vitamin B6 and vitamin B12 were associated with an increased risk of GDM in a nonlinear fashion. Conclusions: Our study shows that higher maternal serum vitamin B1 and B6 levels in early pregnancy are associated with increased GDM risk, while sufficient vitamin B12 status is associated with lower GDM risk.

show abstract

Vitamin B12 and Folate Levels During Pregnancy and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Cited by 13 publications

References 38 publications

DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring

DNA methylation and expression profiles of placenta and umbilical cord blood reveal the characteristics of gestational diabetes mellitus patients and offspring

Vitamin B12 status and folic acid/vitamin B12 related to the risk of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of observational studies

The Association between Maternal B Vitamins in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study

Contact Info

Product

Resources

About