Vitamin B12, bone mineral density and fracture risk in adults: A systematic review

Macêdo, Luciana Leal Gomes de; Carvalho, Cecília Maria Resende Gonçalves de; Cavalcanti, Janaína Costa; Freitas, Betânia de Jesus e Silva de Almendra

doi:10.1590/1806-9282.63.09.801

Cited by 12 publications

(9 citation statements)

References 33 publications

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“…It is well known that postoperative deficiency of vitamin B 12 can lead to anemia [ 44 , 45 ]. Still more importantly, vitamin B 12 deficiency has been associated with osteoporosis, which was reported in a systematic review by Macedo et al [ 46 ]. Today, postoperative vitamin B 12 supplementation is routinely recommended following bariatric surgery [ 47 ].…”

Section: Pathogenic Aspects Of Bone Loss and Nutrient Deficienciesmentioning

confidence: 98%

Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy

Aaseth

Alexander

2023

Nutrients

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Obesity has become a worldwide epidemic accompanied by adverse health effects. The limited efficiency of traditional weight reduction regimens has led to a substantial increase in the use of bariatric surgery. Today, sleeve gastrectomy (SG) and Roux-en-Y-gastric bypass (RYGB) are the most used procedures. The present narrative review focuses on the risk of developing postoperative osteoporosis and summarizes some of the most relevant micronutrient deficiencies associated with RYGB and SG. Preoperatively, the dietary habits of obese individuals might lead to precipitated deficiencies in vitamin D and other nutrients affecting bone mineral metabolism. Bariatric surgery with SG or RYGB can aggravate these deficiencies. The various surgical procedures appear to affect nutrient absorption differently. Being purely restrictive, SG may particularly affect the absorption of vitamin B12 and also vitamin D. In contrast, RYGB has a more profound impact on the absorption of fat-soluble vitamins and other nutrients, although both surgical methods induce only a mild protein deficiency. Despite adequate supplementation of calcium and vitamin D, osteoporosis may still occur after the surgery. This might be due to deficiencies in other micronutrients, e.g., vitamin K and zinc. Regular follow-ups with individual assessments and nutritional advice are indispensable to prevent osteoporosis and other adverse postoperative issues.

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Section: Pathogenic Aspects Of Bone Loss and Nutrient Deficienciesmentioning

confidence: 98%

Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy

Aaseth

Alexander

2023

Nutrients

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“…The association of vitamin B 12 status with bone mineral density and osteoporotic fractures was investigated in a systematic review by Macedo et al, including 6 longitudinal studies, 9 cross-sectional studies, and two RCTs ( 19 ). The authors concluded that the potential effect of vitamin B 12 deficiency on bone health and the underlying mechanisms warrant further research, especially in vulnerable groups such as postmenopausal and elderly women.…”

Section: Health Outcomes Relevant For Nordic and Baltic Countriesmentioning

confidence: 99%

Vitamin B12 – a scoping review for Nordic Nutrition Recommendations 2023

Bjørke-Monsen,

Lysne

2023

Food & Nutrition Research

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Vitamin B 12 (cobalamin) is essential for normal metabolic function, and even moderate deficiency of this vitamin has negative health effects. Vitamin B 12 is found in animal foods, and as vegetarian diets are increasingly popular in Western countries, one might expect a higher prevalence of vitamin B 12 deficiency in the Nordic population. Setting recommendations for vitamin B 12 intake has proven to be difficult, as uptake of vitamin B 12 varies substantially, the clinical deficiency symptoms are often diffuse, and there is no clear agreement on the decision limits for vitamin B 12 deficiency. Vitamin B 12 deficiency is reported to be particularly common among pregnant women and infants, despite the fact that less than 1% of Norwegian pregnant women have a cobalamin intake below the Nordic Nutrition Recommendations 2012-recommended level of 2.0 µg/day. In addition, the assumption that breast milk contains sufficient vitamin B 12 for optimal health and neurodevelopment during the first 6 months of life does not comply with the high prevalence of insufficient vitamin B 12 status in this age group. Recommended intakes of vitamin B 12 vary among age groups and must be based on markers of cobalamin status, indicating an optimal intracellular biochemical status, and not merely absence of clinical signs of vitamin B 12 deficiency.

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“…Macêdo et al (2017) reviewed several studies, in which three of them demonstrated an association between vitamin B12 and fracture risk and/or bone mineral density (BMD reduction), while in fourteen studies no association was recorded[ 25 ]. In another study that Macêdo et al reviewed, it was concluded that supplementation of vitamin B12 and folic acid is beneficial for the prevention of osteoporotic fractures.…”

Section: Investigating the B12-frailty Interplaymentioning

confidence: 99%

“…In another study that Macêdo et al reviewed, it was concluded that supplementation of vitamin B12 and folic acid is beneficial for the prevention of osteoporotic fractures. However further studies are required in order to determine the association between B12 and bone metabolism[ 25 ].…”

Section: Investigating the B12-frailty Interplaymentioning

confidence: 99%

B12 levels and frailty syndrome

Pyrgioti

Karakousis

2022

JFSF

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is of great importance to investigate the possible correlation between these two conditions.This paper reviews the interplay between frailty syndrome and vitamin B12 levels. B12 vitamin profileVitamin B12 as a member of the corrinoids, a group of molecules with a corrin ring structure and central cobalt atom. It is found in many forms such as hydroxocobalamin, methylcobalamin, and 50-deoxyadenosylcobalamin, which

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Vitamin B12, bone mineral density and fracture risk in adults: A systematic review

Cited by 12 publications

References 33 publications

Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy

Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy

Vitamin B12 – a scoping review for Nordic Nutrition Recommendations 2023

B12 levels and frailty syndrome

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