Vitamin C in Clinical Therapeutics

Hemilä, Harri

doi:10.1016/j.clinthera.2017.08.005

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Some recent systematic reviews and meta-analyses suggested that vitamin C significantly decreased the incidence of atrial fibrillation, ventilation time, length-of-stay in the intensive care unit, and hospital length-of-stay, but it had no significant effect on in-hospital mortality or incidence of stroke, acute kidney injury, or ventricular arrhythmia in cardiac surgery patients. The data on the effect of vitamin C on clinical outcomes in patients undergoing cardiac surgery is still insufficient to draw firm conclusions [191][192][193][194].…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

“…The effect of vitamin C in the prevention and treatment of pneumonia is uncertain as well [196,197]. Notwithstanding that the effect is absent in the general population, vitamin C can be effective under specific conditions, such as low levels of vitamin C, e.g., in people under physical stress [6,191,195,198]. The recent clinical trial did not find the effect of intravenous vitamin C infusion on organ failure and biological markers of inflammation and vascular injury in patients with sepsis and acute respiratory distress syndrome, but vitamin C compared with the placebo was associated with a significant reduction in 28-day all-cause mortality [199].…”

Section: Infectionsmentioning

confidence: 99%

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Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

et al. 2021

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Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much higher than its plasma concentrations, and compared to other vitamins. The role of vitamin C is well demonstrated by miscellaneous symptoms of its absence—scurvy. The only clinically well-documented indication for vitamin C is scurvy. The effects of vitamin C administration on cancer, cardiovascular diseases, and infections are rather minor or even debatable in the general population. Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones). Lastly, analytical methods for its determination with advantages and pitfalls are also discussed in this review.

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Section: Cardiovascular Diseasesmentioning

confidence: 99%

Section: Infectionsmentioning

confidence: 99%

Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination

et al. 2021

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“…Ambra Grisea. Ulcers like salt rheum, with gray and salty discharge, in lean thin old aged persons [9] 2. Ammonium carbonicum.…”

Section: Pathophysiologymentioning

confidence: 99%

A homoeopathic approach to skin ulcer with therapeutics

Thebar¹,

Raika²,

Srivastav³

2022

Int. J. Homoeopathic Sci.

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An ulcer is a break in the durability of the epithelium, either skin or mucus membrane due to cellular death. Wound is simply a disruption of any tissue-soft tissue or bone or internal organ i.e. structurally and functionally. Ulcer is break in the continuity of any layer of skin. Ulcer is one of the type of wound. Non healing cutaneous ulcers are commonly seen in diabetes, vascular insufficiency, and other chronic conditions, and this is global health concern and which continuous to increase in annual incidence.

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