Vitamin C Status of Cigarette Smokers an Nonsmokers

Pelletier, Omer

doi:10.1093/ajcn/23.5.520

Cited by 84 publications

(27 citation statements)

References 7 publications

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“…Contrary to expectation (Pelletier, 1970;Hume & Weyers, 1973), there was no evidence that either infections or current smoking had contributed to the low vitamin C values in lung-cancer patients. Leucocyte counts did not correlate inversely with vitamin C values, and the latter were not lower in patients with recent infections.…”

Section: Discussioncontrasting

confidence: 88%

Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance

Anthony¹,

Schorah²

1982

Br J Cancer

106

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Summary.-Plasma and buffy-coat vitamin C were estimated in 158 samples from 139 lung-cancer patients, at all stages of the disease. Most samples showed hypovitaminosis C in both estimations: 64% had plasma, and 25% buffy-coat values below the thresholds for incipient clinical scurvy (0.3 mg% and 10 jg/108 cells respectively).Levels were diet-dependent and could be increased by oral supplements. Levels were low both in tumour-bearing patients and in those clinically free of disease after resection. The latter had particularly low values during the first 6 months, indicating the utilization of vitamin C in surgical repair.The vitamin C content of 13 primary lung tumours was assayed: tumours had a higher vitamin C content (mean 1116 +551 ,ug/g tissue) than normal lung (58.5 + 20-4 ,ug/g).Mononuclear cells from normal individuals show a higher vitamin C content than polymorphs, but in lung -cancer patients the expected correlation of buffy-coat vitamin C with the proportion of lymphocytes in peripheral blood was obscured by an inverse correlation in patients with relative lymphocytosis (.25% lymphocytes), confirmed by an inverse correlation of the proportion of lymphocytes in peripheral blood with mononuclear-cell vitamin C in 14 patients in whom this was measured. These correlations were unaffected by controlling for plasma values, and indicate the utilization of vitamin C in lymphocyte-related anti-tumour mechanisms.Vitamin C is necessary for phagocytosis and for the expression of cell-mediated immunity. In view of the increasing circumstantial evidence that immune mechanisms exert some measure of control on tumour extension and metastasis in man, the effect of supplementation with vitamin C in lung-cancer patients on survival should be tested in a clinical trial.

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Section: Discussioncontrasting

confidence: 88%

Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance

Anthony¹,

Schorah²

1982

Br J Cancer

106

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“…This effect, however, is complicated by the number of moderate to heavy smokers found in the low group. The data showing that smokers had lower levels of plasma vitamin C than non-smokers replicates previous findings (12,13). In addition, the present findings indicate that vitamin supplementation involving 75 mg of vitamin C a day does not ameliorate this condition.…”

Section: Resultssupporting

confidence: 87%

“…Research has also shown that smokers have low levels of vitamin C (12,13). A possible explanation for this effect is that smokers absorb less vitamin C from the gut than non-smokers.…”

mentioning

confidence: 99%

Vitamin C Status of Submariners

Gilman¹,

Biersner²,

Thornton³

1980

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“…The difference in dietary habits between the young and elderly should be considered for the decline in vitamin C concentration with age. Burr et al (1974) and Pelletier (1975) have found that differences between males and females exist where subjects have been matched for dietary intake. Morgan et al (1955) have observed that females maintained higher serum levels of vitamin C on lower intakes than males.…”

Section: Correlationsmentioning

confidence: 99%

“…Morgan et al (1955), Brook and Grimshaw (1968), Burr et al (1974), Pelletier (1975), Attwood et al (1978) and Bates et al (1979) have reported that the value of vitamin C in plasma and leukocytes is higher in females than in males, and the difference persists into old age. Loh and Wilson (1971) have shown that below the age of 60, the females have higher ascorbic acid values than the males, but after this age, the male concentrations exceed those in females.…”

mentioning

confidence: 99%