Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression

Agmon‐Levin, Nancy; Blank, Miri; Zandman‐Goddard, Gisele; Orbach, Hedi; Meroni, Pier Luigi; Tincani, Anǵela; Doria, Andrea; Cervera, Ricard; Miesbach, Wolfgang; Stojanovich, Ljudmila; Barak, Vivian; Porat-Katz, Bat Sheva; Amital, Howard; Shoenfeld, Yehuda

doi:10.1136/ard.2010.134817

Cited by 139 publications

(110 citation statements)

References 45 publications

(45 reference statements)

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“…Additionally, experimental models suggest significant role of complement system and inflammation in APS pathogenesis, which is similar to SLE pathogenesis [49][50][51]. New data indicate role of vitamin D in SLE pathogenesis and also very current are researches of vitamin D role in APS [52]. Based on many similarities with SLE, some authors indicate possible systemic character of APS and raise an intriguing question: are http://www.mjms.mk/ http://www.id-press.eu/mjms/ APS and SLE two separate autoimmune disorders or represent one same autoimmune phenomenon?…”

Section: Is Antiphospholipid Syndrome a Systemic Autoimmune Disorder?mentioning

confidence: 89%

Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Plavšić¹,

Mišković²,

Rašković

et al. 2014

Open Access Maced J Med Sci

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Antiphospholipid syndrome is an autoimmune disorder defined as association of vascular thrombosis and/or pregnancy complications with presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin and anti-β2 glycoprotein I). It is the most common cause of acquired thrombophilia, and can occur as an independent entity or in relation with other diseases, especially systemic lupus erythematosus. Presence of antiphospholipid syndrome in systemic lupus erythematosus is additional vaso occlusive factor in already present inflammation, bringing further risk for thrombotic events. Clinical and serological manifestations of antiphospholipid syndrome and systemic lupus erythematosus are very similar, so possible connection for these two autoimmune disorders is assumed.

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Section: Is Antiphospholipid Syndrome a Systemic Autoimmune Disorder?mentioning

confidence: 89%

Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Plavšić¹,

Mišković²,

Rašković

et al. 2014

Open Access Maced J Med Sci

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show abstract

“…It was shown that ~ 50% of patients had vitamin D deficiency (<15ng/ml) which correlates with thrombotic complications and other clinical manifestations of the syndrome (neurological, ocular, livedo reticularis and skin ulcers). In vitro, vitamin D seems to suspend the anti-2GPI-induced expression of TF [ 67 ]. The role of anti-endothelial antibodies, especially of anti-HSP60, in the mechanism of thrombosis was studied in LA positive patients with secondary APS [ 68 ].…”

Section: Clinical and Laboratory Characteristicsmentioning

confidence: 99%

Pathogenic Mechanisms of Thrombosis in Antiphospholipid Syndrome (APS)

Sikara¹,

Grika²,

Vlachoyiannopoulos³

2011

Thrombophilia

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“…Numerous infectious agents have been related to autoimmunity and production of autoantibodies [20][21][22] as well as with evident diseases such as SLE and APS [23][24][25][26][27]. Additional factors such as hormones [28,29], vitamins such as vitamin D [30][31][32], sun exposure, etc. were also allied the pathogenesis of both SLE and APS [33].…”

mentioning

confidence: 99%