Vitamin D and IBD: More Pieces to the Puzzle, Still No Complete Picture

Silva, Punyanganie S. de; Ananthakrishnan, Ashwin N.

doi:10.1002/ibd.22854

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…This deficiency is thought to be related to reduced physical activity, reduced sunlight exposure, malnutrition, inadequate dietary intake, or lower bioavailability. It is also possible that vitamin D affects the immune system through T cells, B cells, and antigen-presenting cells, impacting disease development and/or course 72. A study from a large prospective cohort of female nurses initiated in 1976 and 1989, respectively, revealed that women living in southern latitudes had a lower risk of CD (HR 0.48, 95% CI 0.30–077) and UC (HR 0.62, 95% CI 0.42–0.90) when compared to those residing in northern latitudes 73.…”

Section: Medicationsmentioning

confidence: 99%

A clinical review of recent findings in the epidemiology of inflammatory bowel disease

Ponder

Long

2013

CLEP

134

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Inflammatory bowel diseases (IBD), including both Crohn’s disease and ulcerative colitis, are disorders of chronic inflammation of the gastrointestinal tract marked by episodes of relapse and remission. Over the past several decades, advances have been made in understanding the epidemiology of IBD. The incidence and prevalence of both Crohn’s disease and ulcerative colitis have been increasing worldwide across pediatric and adult populations. As IBD is thought to be related to a combination of individual genetic susceptibility, environmental triggers, and alterations in the gut microbiome that stimulate an inflammatory response, understanding the potentially modifiable environmental risk factors associated with the development or the course of IBD could impact disease rates or management in the future. Current hypotheses as to the development of IBD are reviewed, as are a host of environmental cofactors that have been investigated as both protective and inciting factors for IBD onset. Such environmental factors include breast feeding, gastrointestinal infections, urban versus rural lifestyle, medication exposures, stress, smoking, and diet. The role of these factors in disease course is also reviewed. Looking forward, there is still much to be learned about the etiology of IBD and how specific environmental exposures intimately impact the development of disease and also the potential for relapse.

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Section: Medicationsmentioning

confidence: 99%

A clinical review of recent findings in the epidemiology of inflammatory bowel disease

Ponder

Long

2013

CLEP

134

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“…Notably, patients with IBD mainly experience a loss of appetite due to nausea, vomiting, abdominal pain and diarrhea, and folate deficiency has classically been associated with anemia in these patients (16)(17)(18)(19). Thus, vitamins, such as vitamin D, vitamin B6, vitamin B12 and vitamin C, are occasionally recommended for patients with IBD (20)(21)(22)(23)(24). Several studies have shown that vitamin D supplementation can prevent and ameliorate symptoms of IBD (25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the anti‑inflammatory effects of vitamin E and vitamin D on a rat model of dextran sulfate sodium‑induced ulcerative colitis

Fan¹,

Yin²,

Yin³

et al. 2023

Exp Ther Med

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The present study aimed to compare the clinical effects of vitamin E and vitamin D on a rat model of dextran sulfate sodium (DSS)-induced ulcerative colitis (UC), and to elucidate the underlying mechanisms associated with changes in the levels of cytokines. After successful establishment of the rat model of DSS-induced UC, prednisolone (1 mg/kg), vitamin D (50 ng) and vitamin E (6, 30 and 150 IU/kg) were orally administered for 1 week. The pharmacodynamics were evaluated by a daily combination of clinical observation (CO) scores, histopathological evaluations and assessment of molecular markers of inflammation. Administration of vitamin D, vitamin E (30 and 150 IU/kg), prednisolone, and the combination of vitamin D and vitamin E resulted in a decrease in CO scores. The severity of inflammation of the colon was markedly alleviated in the treatment groups compared with that in the untreated DSS group according to the results of histopathological examination; however, they showed different inhibitory effects on the levels of some cytokines. In conclusion, the present results indicated that oral administration of vitamin E could promote recovery of DSS-induced UC by the inhibition of proinflammatory cytokines, and that its underlying mechanism may differ from that of vitamin D and glucocorticoid drugs.

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Vitamin D Prevents the Intestinal Fibrosis Via Induction of Vitamin D Receptor and Inhibition of Transforming Growth Factor-Beta1/Smad3 Pathway

et al. 2014

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Vitamin D and IBD: More Pieces to the Puzzle, Still No Complete Picture

Cited by 5 publications

References 15 publications

A clinical review of recent findings in the epidemiology of inflammatory bowel disease

A clinical review of recent findings in the epidemiology of inflammatory bowel disease

Comparison of the anti‑inflammatory effects of vitamin E and vitamin D on a rat model of dextran sulfate sodium‑induced ulcerative colitis

Vitamin D Prevents the Intestinal Fibrosis Via Induction of Vitamin D Receptor and Inhibition of Transforming Growth Factor-Beta1/Smad3 Pathway

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