Vitamin D and methylarginines in chronic kidney disease (CKD)

Torino, Claudia; Pizzini, Patrizia; Cutrupi, Sebastiano; Tripepi, Rocco; Tripepi, Giovanni; Mallamaci, Francesca; Zoccali, Carmine

doi:10.1371/journal.pone.0185449

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Additionally, the authors assessed the impact of age, sex, and body weight on the concentration of this parameter in this species and correlated the SDMA values with serum creatinine and urea values. The obtained SDMA values in blood serum in healthy adult horses correspond to the results obtained by Schott et al (2018) in draft horses and are similar to the reference values in humans (from 0.3 to 0.7 μmol/L), dogs (from 0.28 to 0.58 μmol/L) and cats (from 0.35 to 0.6 μmol/L) [4,19,[22][23][24][25].…”

Section: Discussionsupporting

confidence: 90%

Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury

et al. 2020

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Background There are limited options to diagnose acute kidney injury (AKI) in horses. Symmetric dimethylarginine (SDMA) is routinely used in human and small animal medicine. The aim of this study was to assess serum SDMA concentrations in healthy horses and horses with AKI. The objective of this study was to evaluate the association of: 1) age, 2) sex, 3) body weight and 4) serum creatinine and urea levels on serum SDMA concentrations. Fifty-three healthy horses, including 17 foals (2–6 months of age) and 36 adult horses (3–29 years of age), and 23 horses with AKI were included in the study based on history, physical examination, blood analysis, urinalysis and an ultrasonographic examination of the urinary tract. Serum SDMA concentrations were measured using a non-species specific commercial ELISA test. Results In healthy adult horses, the value of SDMA was 0.53 ± 0.14 μmol/L. The value was higher in foals (1.5 ± 0.4 μmol/L, P < 0.001). Horses with AKI had significantly higher concentrations of SDMA compared to healthy horses (1.76 ± 1.05 μmol/L, P < 0.001). In the healthy adult horses, there was no association of sex, age or body weight on SDMA. However, a significant positive relationship was found between serum creatinine and SDMA concentrations. Conclusions Healthy adult horses had SDMA values similar to those of other species. Foals had higher SDMA values. Therefore, different reference values should be created for them. The study confirmed an increased SDMA in horses with AKI. This, as well as the low influence of extrarenal factors on the SDMA values, may confirm its usefulness in the diagnosis of kidney dysfunction. Higher SDMA values may also indicate a more advanced degree of kidney dysfunction. Further research is required to determine whether SDMA could be used to detect kidney dysfunction in the asymptomatic stage of AKI.

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Section: Discussionsupporting

confidence: 90%

Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury

et al. 2020

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“…The PENNY trial (Paricalcitol and ENdothelial fuNction in chronic kidneY disease trial) [84] showed that paricalcitol improves endothelium-dependent vasodilatation in patients with stage 3–4 CKD. However, in a publication by the same group, the group found that paricalcitol did not modify plasma ADMA and SDMA in patients with stage 3–4 CKD [85].…”

Section: Adma and Drugs: A Modifiable Risk Factor?mentioning

confidence: 99%

Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach

Oliva-Damaso

Oliva-Dámaso

Rodrı́guez-Esparragón

et al. 2019

IJMS

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Asymmetric dimethylarginine (ADMA) and its enantiomer, Symmetric dimethylarginine (SDMA), are naturally occurring amino acids that were first isolated and characterized in human urine in 1970. ADMA is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD). ADMA has shown to be a significant predictor of cardiovascular outcome and mortality among dialysis patients. On the other hand, although initially SDMA was thought to be an innocuous molecule, we now know that it is an outstanding marker of renal function both in human and in animal models, with ESRD patients on dialysis showing the highest SDMA levels. Today, we know that ADMA and SDMA are not only uremic toxins but also independent risk markers for mortality and cardiovascular disease (CVD). In this review, we summarize the role of both ADMA and SDMA in chronic kidney disease along with other cardiovascular risk factors.

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“…However, unlike other studies, Pincombe et al 26 argued in their meta-analysis study that vitamin D supplementation had no effect on endothelial dysfunction and that more evidence should be presented before vitamin D supplementation was applied for the treatment of endothelial dysfunction. Torino et al 27 administered vitamin D to patients with stage III and IV chronic kidney disease for 12 weeks and found that there was no change in ADMA and SDMA levels.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D supplementation on symmetric dimethyl arginine, asymmetric dimethyl arginine, homocysteine levels in rats being exposed to gamma radiation

et al. 2021

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Background: Radiation causes to damage on endothelial cells by increasing oxidative stress. Vitamin D is also a potent anti-oxidant that facilitates balanced mitochondrial activities, preventing oxidative stress-related protein oxidation, lipid peroxidation, and DNA damage. Aims and Objective: We aimed to investigate the potential effect of vitamin D supplementation on levels of Hcy (homocysteine), ADMA (Asymmetric Dimethyl Arginine), and SDMA (Symmetrical Dimethyl Arginine) which are admitted as endothelial dysfunction markers in rat models that are exposed to gamma radiation. Materials and Methods: Twentyfour female Wistar Albino rats were selected for the study. The mean weight of these rats were between 200 and 250 grams. Rats were fed with standard light (12 hours day light /12 hours dark), enough water (ad-libitum) at temperature (25ºC) for a total of 4 weeks. The rats were divided into 4 different groups and each group consisted of 6 rats. controlgroup (group I) did not receive any supplementation and not expose to gamma radiation), Group II was merely exposed to gamma radiation, Group III was exposed to gamma radiation and received vitamin D supplementation, and Group IV merely received vitamin D supplementation. Groups that are given vitamin D supplementation were fed by oral gavage at the same time and every day for one week. Finally, Group II and Group III were exposed to gammaradiation at the 8th day. After the completion of all processes, Vitamin D, ADMA, SDMA and Hcy levels were measured by HPLC (High-performance liquid chromatography) method. Results: When the results of Group II and Group III were compared with each other, we achieved merely statistical significance in vitamin D results (p=0.04) but did not other parameters (p>0.05). Conclusion: We observed that vitamin D supplementation did not any effect on SDMA, ADMA, and Hcy that accompany possible endothelial dysfunction after gamma radiation exposure.

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Vitamin D and methylarginines in chronic kidney disease (CKD)

Cited by 4 publications

References 38 publications

Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury

Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury

Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach

Effect of Vitamin D supplementation on symmetric dimethyl arginine, asymmetric dimethyl arginine, homocysteine levels in rats being exposed to gamma radiation

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