Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis

Abstract

BackgroundIn addition to its important metabolic activities, vitamin D also contributes to the regulation of the immune system. The aim of this study was to assess the relationship between hypovitaminosis D and disease activity in Moroccan children with juvenile idiopathic arthritis (JIA).MethodsIn this cross-sectional study, forty children with JIA were included, all having been diagnosed according to the classification criteria of International League of Associations for Rheumatology (ILAR). The children underwent anthropometric assessment and clinical evaluation. Disease activity was measured using the Disease Activity Score in 28 joints (DAS28) for polyarticular and oligoarticular JIA and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for enthesitis-related arthritis. Serum 25-hydroxyvitamin [25(OH)D] D2 and D3 were measured using radioimmunoassay (RIA). Hypovitaminosis D was defined as serum 25(OH)D <30 ng/ml.ResultsThe average age of participants was 11 years ± 4.23. Hypovitaminosis D was observed in 75% of patients. In univariate analyses, 25(OH)D levels were negatively associated with DAS28 for polyarticular and oligoarticular JIA. No significant relationship was found between 25(OH)D levels and BASDAI for juvenile spondylarthropathy. In multivariate linear regression analysis, no association persisted between 25(OH)D levels and DAS28.ConclusionsOur study suggested that serum levels of vitamin D were low in Moroccan children with JIA disease. Future studies with a larger population are needed to confirm our results.

Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever

“…However, they detected high levels of vitamin D deficiency and insufficiency in healthy children and patients (deficiency was found with a rate of 26.7% and insufficiency was found with a rate of 46.7% in the patients with JIA; deficiency was found with a rate of 16.7% and insufficiency was found with a rate of 60% in the healthy children). In a crosssectional study conducted by Bouaddi et al 24 with Moroccan children, 75% of the patients with JIA were found to be vitamin D deficient. However, no correlation was demonstrated between vitamin D level and disease activity.…”

Adjunctive vitamin D for the treatment of active juvenile idiopathic arthritis: An open‑label, prospective, randomized controlled trial

“…Vitamin D regulates the innate and adaptive immune systems by activating the vitamin D receptor, which is distributed widely on immune cells (7,8). Consequently, vitamin D deficiency is associated with autoimmune diseases such as diabetes, rheumatoid arthritis, systemic lupus erythematosus, and JIA (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). A previous study reported suboptimal vitamin D levels in JIA patients (13).…”

Ab0994 vitamin D Status in Children With Jia Depending on the Season

“…Results: We followed 31 patients (81% female) suffering from JIA with ocular manifestations. Median age at JIA onset in girls was 2.5 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) years and in boys 8.6 (1-14.5) years, while girls had median age 4.25 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) years at first ocular manifestation and boys 8.25 (4 -13.5) years. All patients were RF negative.…”

“…Background: Plenty of studies demonstrated the relationship between vitamin D and Juvenile idiopathic arthritis (JIA) disease activity [1,2] .Others reported no relationship between 25(OH)D and disease activity [3,4] . The main source of vitamin D is endogenous vitamin D synthesis induced by sunlight exposure.…”