Vitamin D deficiency and low osteocalcin concentrations in anorexia nervosa.

Fonseca, V.; D'Souza, V; Houlder, S; Miles, Thomas J.; Wakeling, A.; Dandona, Paresh

doi:10.1136/jcp.41.2.195

Cited by 59 publications

(39 citation statements)

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“…In K, 3 wk of nutritional rehabilitation produced a significant rise in both of these proteins (6), suggesting that serum osteocalcin level is sensitive to nutritional status. This is strengthened by the low osteocalcin levels found in patients suffering from anorexia nervosa (22), in 3-day starved rats (21), or after 4 wk of dietary restriction in rats (23), whereas high osteocalcin levels are found in obese children fed an energy-rich diet (24). Michaelsen et al (25) have found a positive correlation between serum osteocalcin and milk intake in a study of 2-to 9-mo-old breast-fed babies.…”

Section: Discussionmentioning

confidence: 88%

Serum Osteocalcin Regulation in Protein-Energy Malnourished Children

Ndiaye

Lemonnier

Sall³

et al. 1995

Pediatr Res

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To evaluate bone turnover changes occurring during proteinenergy malnutrition, serum osteocalcin, a marker of bone formation, has been studied in healthy control, stunted, and severely malnourished (kwashiorkor and marasmus) Senegalese children. Serum osteocalcin levels were dramatically reduced in stunted, kwashiorkor, and marasmic childrencompared with control children. In addition serum osteocalcin levels of control children living in Senegal were lower (-46%) than those of African children living in France. Interestingly, serum osteocalcin level was not related to its major known regulator s (la,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol, and PTH) nor to stunting,but was related to serum transthyretin and thyroid hormones concentrations. These data suggest that serum osteocalcin level is related to protein-energy status and that bone formation was affected in apparently healthy and in malnourished PEM is a great probl em which concerns about half the world' s children. However, contrary to other aspects of PEM , bone metabolism has received little attention. Most of the studies on bone are from the last decades and were hindered by the lack of appropriate tools for investigation of bone turno ver. Previous studies based on radiography or ash weights have suggested an increase of bone resorption (1), whereas recently, Branca et al. (2), using urinary pyridinoline and deox ypyridinoline concentrations, have dem onstrated that bone resorption is decre ased in PEM. Thanks to the availability of new specific biochemical mark ers, such as osteocalcin, it was found relevant to reevalute with more insight the other side of bone turnover, i.e. bone formation.Osteocalcin is the most abundant noncollagenous bone protein and is produced by osteoblast (3). Most of the newly synthesized osteocalcin remains bound to bone hydroxyapatite, but a small fraction of the protein is released into the blood (3, 4) and serum osteocalcin appears to be an useful marker of Senegalese children.Serum osteocalcin could be a potent tool in the study of the alterations of bone formation in malnutrition. (Pediatr Res 37: 606-610, 1995) Abbreviations 1,25(OH)2D, la,25-dihydroxycholecalciferol 25(OH)D, 25-hydroxycholecalciferol CD, control children living in Dakar CP, control children living in Paris iPTH, immunoreactive PTH K, kwashiorkor children M, marasmic children MS, moderately stunted children PEM , protein-energy malnutrition SS, severely stunted children bon e formation (4). To further clarify possibl e effects of PEM on bone form ation , serum osteocalcin concentrations were determi ned in groups of children from Senegal (West Africa) with various forms of malnutrition in relation to mark ers of the protein energy and the inflammation status. In addition, the main regulators of osteocalcin synthesis, i.e. 1,25(OH)2D and parath yroid and thyroid hormones, were measured to investigate the regulation of serum osteocalcin concentration in PEM . METHODSOur criteria for inclusion in the study were based on age and anthropome...

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Section: Discussionmentioning

confidence: 88%

Serum Osteocalcin Regulation in Protein-Energy Malnourished Children

Ndiaye

Lemonnier

Sall³

et al. 1995

Pediatr Res

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“…However, TGF-β1 stimulates vitamin D receptor expression in mature osteoblast cell line. Fonseca et al [48] reported prevalent vitamin D insufficiency in young women with AN. Calcium and vitamin D intake among patients with AN is presumably low due to dietary restriction.…”

Section: Discussionmentioning

confidence: 99%

TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

Ostrowska

Ziora

Oświęcimska

et al. 2016

Endokrynologia Polska

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Introduction: Numerous investigations, and especially in vitro studies, indicate that TGF-β1 may act as an important regulator of bone remodelling. Thus, it could be expected that disturbances of this cytokine production observed by several researchers might play a role in the mechanism leading to the development of osteoporosis in girls with anorexia nervosa (AN). The aim of the study was to determine whether 1) girls with AN exhibited a relationship between TGF-β1 and bone metabolism (as assessed based on serum OC and CTx concentrations) and 2) whether OPG and sRANKL might modify the possible relationship between TGF-β1 and bone metabolism. Material and methods: Serum concentrations of TGF-β, OC, CTx, OPG, and its soluble ligand sRANKL were determined by ELISA in 60 girls with AN and in 20 healthy controls (C). All study participants were aged 13 to 17 years. Results: Body weight, BMI, BMI-SDS and the Cole index, serum TGF-β1, OC, CTx, and the OPG/sRANKL ratio were significantly reduced, while OPG and sRANKL levels were significantly increased, in girls with AN compared to healthy participants. BMI and the Cole index correlated negatively and significantly with serum CTx and OPG (AN group) or CTx only (groups C and C + AN). Girls with AN showed a positive and significant correlation between the Cole index and serum TGF-β1. The combination group (C + AN) showed a positive and significant correlation between BMI, the Cole index, and the OPG/sRANKL ratio and TGF-β1 concentration, while TGF-β1 correlated positively and significantly with OC concentrations and the OPG/sRANKL ratio. The Cole index and BMI were identified to be significant and independent predictors of CTx (C, AN, and C+AN groups) and OPG (AN group); the Cole index, BMI, and TGF-β1 independently predicted the OPG/sRANKL ratio (C, AN, and C + AN groups); TGF-β1 was found to be an independent predictor of OC (C + AN group). Conclusions: Changes in bone markers, OPG, and/or OPG/sRANKL ratio observed in girls with AN are associated with changes in serum TGF-β1 concentrations. TGF-β1 suppression in girls with AN might lead to disturbances in the relationship between bone metabolism and the OPG/sRANKL system, which, in turn, might compromise the mechanism compensating for bone remodelling disturbances. (Endokrynol Pol 2016; 67 (5): 493-500)

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“…Fonseca et al measured serum vitamin D concentrations in 17 young adults with AN [6]. The participants' dietary intake was less than 50 IU daily and only one patient was receiving vitamin D supplementation; the median serum concentration of 25-hydroxyvitamin D (25OHD) was significantly lower than controls.…”

Section: Introductionmentioning

confidence: 99%

“…The vitamin D status of teenagers with AN, with its implications for bone health, has only been examined previously in small studies [4,[6][7][8]. Fonseca et al measured serum vitamin D concentrations in 17 young adults with AN [6].…”

Section: Introductionmentioning

confidence: 99%

Low prevalence of vitamin D deficiency among adolescents with anorexia nervosa

et al. 2007

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Summary-Fifty adolescents with AN and 200 healthy girls underwent vitamin D screening. Girls with AN reported exceptional compliance with vitamin D supplementation and PTH concentrations were lower. Vitamin D deficiency was less common in the group with AN, but when race was considered, the trend was no longer significant.Introduction-The objective of this study was to determine whether patients with anorexia nervosa (AN) are more compliant with supplementation and have a lower prevalence of vitamin D deficiency than healthy controls.

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Vitamin D deficiency and low osteocalcin concentrations in anorexia nervosa.

Cited by 59 publications

References 13 publications

Serum Osteocalcin Regulation in Protein-Energy Malnourished Children

Serum Osteocalcin Regulation in Protein-Energy Malnourished Children

TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

Low prevalence of vitamin D deficiency among adolescents with anorexia nervosa

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