Vitamin D Deficiency, Supplementation, and Cardiovascular Health

Trehan, Naveen; Afonso, Luís; Levine, Diane; Levy, Phillip D.

doi:10.1097/hpc.0000000000000122

Cited by 37 publications

(25 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many other health benefits are associated with higher 25(OH)D concentrations, including reduced risk of autoimmune diseases (133), diabetes mellitus type 2 (134), adverse pregnancy and birth outcomes (135), respiratory tract infections (136), and all-cause mortality rate (137). Whether vitamin D reduces risk of cardiovascular disease is still uncertain based on support from observational studies but not clinical trials (138). Thus, raising 25(OH)D concentrations in an effort to reduce cancer risk will yield additional benefits.…”

Section: Summary Tablementioning

confidence: 99%

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

Grant

2018

View full text Add to dashboard Cite

The vitamin D-cancer prevention hypothesis has been evaluated through several types of studies, including geographical ecological studies related to indices of solar ultraviolet-B (UVB) dose (the primary source of vitamin D for most people), observational studies related to UVB exposure or serum 25-hydroxyvitamin D [25(OH)D] concentrations, laboratory studies of mechanisms, and clinical trials. Each approach has strengths and limitations. Ecological studies indirectly measure vitamin D production and incorporate the assumption that vitamin D mediates the effect of UVB exposure. Findings from observational studies with long follow-up times are affected by changing 25(OH)D concentrations over time. Most clinical trials have been poorly designed and conducted, based largely on guidelines for pharmaceutical drugs rather than on nutrients. However, three clinical trials do support the hypothesis. In general, the totality of the evidence, as evaluated using Hill's criteria for causality in a biological system, supports the vitamin D-cancer prevention hypothesis.

show abstract

Section: Summary Tablementioning

confidence: 99%

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

Grant

2018

View full text Add to dashboard Cite

show abstract

“…Humans obtain vitamin D from exposure to sunlight, diet and dietary supplements (1,2) . Although there is no consensus on optimal 25-hydroxyvitamin D (25(OH)D) concentrations as measured in serum, vitamin D deficiency (VDD) is commonly defined as a 25(OH)D concentration of <50 nmol/l (20 ng/ml) (1)(2)(3)(4) . This cut-off is the point where parathyroid hormone (PTH) starts to rise, which is the physiological definition of VDD (1) , although vitamin D supplementation (e.g.…”

mentioning

confidence: 99%

Vitamin D deficiency and insufficiency among US adults: prevalence, predictors and clinical implications

2018

Self Cite

View full text Add to dashboard Cite

Vitamin D deficiency (VDD) and insufficiency (VDI) are increasing at a global level, and they are associated with increased risk of various diseases. However, little information is available on the prevalence and predictors of VDD and VDI in a representative population of US adults. Serum 25-hydroxyvitamin D (25(OH)D) measurements were collected from 26 010 adults aged ≥18 years from the National Health and Nutrition Examination Survey (NHANES) 2001-2010. Using thresholds recommended by the Endocrine Society, VDD was defined as 25(OH)D<50 nmol/l and VDI as 50≤25(OH)D<75 nmol/l. Weighted multinomial log-binomial regression was conducted to estimate prevalence ratios of VDD and VDI. The prevalences of VDD and VDI in 2001-2010 were 28·9 and 41·4 %, respectively. Adults who were black, less educated, poor, obese, current smokers, physically inactive and infrequent milk consumers had a higher prevalence of VDD. After adjustment for other potential predictors, obese adults showed 3·09 times higher prevalence of VDD and 1·80 times higher prevalence of VDI than non-obese adults. Physically inactive adults had 2·00 and 1·36 times higher prevalence of VDD and VDI than active peers. Compared with frequent consumers, rare consumers of milk had 2·44 and 1·25 times higher prevalence of VDD and VDI, respectively. Current alcohol drinkers had 38 % lower prevalence of VDD than non-drinkers. Awareness of the high prevalence of VDD and VDI among US adults and related predictors could inform behavioural and dietary strategies for preventing VDD and monitoring VDI, especially in old, black, obese and inactive individuals who report rare consumption of milk.

show abstract

“…For example in a recent review article, it has been reported that VDBP polymorphism may affect the binding affinity for vitamin D, thereby, increasing the risk of vitamin D deficiency and other CVDs. 22 Lafi et al have also reported an association of VDBP polymorphism with increased risk of vitamin D deficiency among healthy Jordanians. 23 On the other hand, Michos et al showed that low serum levels of 25(OH)D were associated with increased incidence of CHD among Whites, however, no interaction of 25(OH)D levels with VDBP genotypes was found in that population.…”

Section: Discussionmentioning

confidence: 95%

Association of Vitamin D deficiency and VDBP gene polymorphism with the risk of AMI in a Pakistani population

et al. 2017

View full text Add to dashboard Cite

Objective:To investigate the relationship of vitamin D deficiency and risk of AMI in a Pakistani population, and to find out any association between vitamin D binding protein (VDBP) genotypes and risk of AMI in this population.Methods:In a comparative cross-sectional study, 246 patients (age: 20-70 years; 171 males and 75 females) with first AMI were enrolled with informed consent. Similarly, 345 healthy adults (230 males and 115 females) were enrolled as controls. Their fasting serum samples were analyzed for 25 (OH) vitamin D, lipids and other biomarkers using kit methods, while DNA was analyzed for VDBP genotypes using PCR-RFLP based methods. Chi-squared test and logistic regression were used for association of vitamin D deficiency and VDBP genotypes with AMI.Results:Mean serum concentration of 25(OH) vitamin D was significantly lower in AMI patients compared to healthy subjects (p=0.015) and percent vitamin D deficiency was higher in AMI patients compared to healthy subjects (p=0.003). VDBP IF-IF genotype was positively associated with the risk of AMI in subject above 45 years after adjusting for potential confounders [OR = 9.86; 95% CI=1.16 to 83.43].Conclusion:Vitamin D deficiency and VDBP IF-IF genotype are associated with AMI in Pakistani adults.

show abstract

Vitamin D Deficiency, Supplementation, and Cardiovascular Health

Cited by 37 publications

References 128 publications

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

Vitamin D deficiency and insufficiency among US adults: prevalence, predictors and clinical implications

Association of Vitamin D deficiency and VDBP gene polymorphism with the risk of AMI in a Pakistani population

Contact Info

Product

Resources

About