Vitamin D from different sources is inversely associated with Parkinson disease

Wang, Liyong; Evatt, Marian L.; Maldonado, Lizmarie; Perry, William; Ritchie, James C.; Beecham, Gary W.; Martin, Eden R.; Haines, Jonathan L.; Pericak‐Vance, Margaret A.; Vance, Jeffery M.; Scott, William K.

doi:10.1002/mds.26117

Cited by 70 publications

(63 citation statements)

References 39 publications

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“…Several epidemiological studies have evaluated the potential association between serum vitamin D concentrations and PD. Four US‐based case‐control studies have reported a higher prevalence of vitamin D deficiency in PD patients than in controls or a dose‐response relationship between serum 25(OH)D concentrations and the odds of PD . One study conducted in the Faroese population did not find any association .…”

Section: Discussionmentioning

confidence: 96%

“…For instance, studies have demonstrated that administration of 1,25‐dihydroxyvitamin D 3 attenuates the toxic effects of 6‐hydroxydopamine on nigrostriatal dopaminergic neurons in rats . Multiple epidemiological studies have shown that relative to controls, PD cases have lower serum/plasma levels of 25‐hydroxyvitamin D (25(OH)D), a measure of vitamin D sufficiency status . However, interpretation of these cross‐sectional comparisons is not straightforward because of concerns about reverse causation because sun exposure influences 25(OH)D levels and PD patients may be less likely to spend time outdoors.…”

mentioning

confidence: 99%

“…6,7,9 Multiple epidemiological studies have shown that relative to controls, PD cases have lower serum/plasma levels of 25hydroxyvitamin D (25(OH)D), a measure of vitamin D sufficiency status. [10][11][12][13] However, interpretation of these cross-sectional comparisons is not straightforward because of concerns about reverse causation because sun exposure influences 25(OH)D levels and PD patients may be less likely to spend time outdoors. To the best of our knowledge, only 1 prospective study has examined the association between serum vitamin D and risk of PD.…”

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confidence: 99%

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Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk

et al. 2016

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Background Low vitamin D levels are common among patients with Parkinson’s disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. Objectives We prospectively assessed the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort. Methods Serum samples were collected in 1990–1992 and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association between serum 25-hydroxyvitamin D concentrations and PD risk, regardless of how serum 25-hydroxyvitamin D was modeled. Compared to participants with serum 25-hydroxyvitamin D < 20 ng/mL, the hazards ratio for PD was 1.05 (95% confidence interval = 0.58, 1.90) for 20–30 ng/mL and 1.14 (95% confidence interval = 0.59, 2.23) for ≥ 30 ng/mL. Similar results were obtained in sensitivity analyses that included white participants only and that were stratified by the length of follow-up. Conclusion This prospective study lends no support to the hypothesis that vitamin D may reduce the risk of PD.

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Section: Discussionmentioning

confidence: 96%

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confidence: 99%

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confidence: 99%

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Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk

et al. 2016

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“…For example, the first epidemiological risk study from Finland found lower baseline vitamin D levels in individuals who went on to develop PD compared to those who did not, but the more recent prospective Atherosclerosis Risk in Communities (ARIC) study cohort of almost 13,000 subjects found no association between baseline vitamin D levels and risk of PD 17 years later . Moreover, whereas studies involving populations with more advanced PD have consistently shown associations between decreased vitamin D and PD, they face potential confounding attributed to reduced sun exposure, leading to reduced dermal synthesis of Vitamin D, in patients with progressive motor limitations.…”

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confidence: 99%

Vitamin D in the Parkinson Associated Risk Syndrome (PARS) study

et al. 2017

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Background Lower vitamin D levels have been associated with manifest Parkinson’s disease, prompting the hypothesis that vitamin D insufficiency or deficiency may increase risk for PD. Objectives To evaluate vitamin D levels in a population at risk for developing PD. Methods Plasma vitamin D levels were measured in the Parkinson Associated Risk Syndrome Study, a cohort of asymptomatic individuals, some of whom are at high risk for PD. Vitamin D levels were compared between subjects at high risk for PD (hyposmia and dopamine transporter scan deficit) versus all others and examined for correlations with dopaminergic system integrity. Results Mean vitamin D levels did not differ between groups, with a level of 27.8 ng/mL (standard deviation = 12.0) in the high-risk group versus 24.7 ng/mL (standard deviation = 9.0) in all others (P = 0.09). Vitamin D levels did not associate with putaminal dopamine transporter uptake. Conclusions Our data from the asymptomatic Parkinson Associated Risk Syndrome cohort do not support the hypothesis that chronic vitamin D insufficiency threatens dopaminergic system integrity, contributing to PD pathogenesis.

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“…Although the evidence for this is weak, early studies suggest that PD mortality is higher in the northern regions of the United States . The point has been made that age‐adjusted PD incidence is slightly higher in Finland when compared with California, Minnesota, and New York City . It is also higher in the Faroe Islands between Norway and Iceland .…”

mentioning

confidence: 99%