Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis

Sukik, Ayah; Alalwani, Joud; Ganji, Vijay

doi:10.3390/ijms24020940

Cited by 15 publications

(6 citation statements)

References 77 publications

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“…In addition, a high nutritional intake of vitamin D seems to induce a shift in bacterial composition and affects the species’ richness with a reduction in Veillonellaceae and Oscillospiraceae families, in the Firmicutes phylum with increasing levels of vitamin supplementation. In line with this, emerging evidence suggests that vitamin D deficiency links to CMD through GM [ 71 ] and that vitamin D status may play a role in regulating the GM composition by inhibiting the growth of pathogenic bacteria while nourishing the beneficial strains [ 72 ].…”

Section: Effects Of Diet On Gm Compositionmentioning

confidence: 99%

Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease

2023

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The cardiovascular and metabolic disorders, collectively known as cardiometabolic disease (CMD), are high morbidity and mortality pathologies associated with lower quality of life and increasing health-care costs. The influence of the gut microbiota (GM) in dictating the interpersonal variability in CMD susceptibility, progression and treatment response is beginning to be deciphered, as is the mutualistic relation established between the GM and diet. In particular, dietary factors emerge as pivotal determinants shaping the architecture and function of resident microorganisms in the human gut. In turn, intestinal microbes influence the absorption, metabolism, and storage of ingested nutrients, with potentially profound effects on host physiology. Herein, we present an updated overview on major effects of dietary components on the GM, highlighting the beneficial and detrimental consequences of diet–microbiota crosstalk in the setting of CMD. We also discuss the promises and challenges of integrating microbiome data in dietary planning aimed at restraining CMD onset and progression with a more personalized nutritional approach.

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Section: Effects Of Diet On Gm Compositionmentioning

confidence: 99%

Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease

2023

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“…Vitamin D is a fat-soluble vitamin synthesized endogenously when exposed to UV sunlight and can be obtained from food sources [93,94]. Vitamin D requirements range from 10-20 mcg depending on age and physiological status.…”

Section: Vitamin Dmentioning

confidence: 99%

Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

Ferenc,

Sokal-Dembowska,

Helma

et al. 2024

IJMS

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The intestinal microbiota is a community of microorganisms inhabiting the human intestines, potentially influencing both physiological and pathophysiological processes in the human body. Existing evidence suggests that nutrients can influence the modulation of the gut microbiota. However, there is still limited evidence regarding the effects of vitamin and mineral supplementation on the human gut microbiota through epigenetic modification. It is plausible that maintaining an adequate dietary intake of vitamin D, iron, fibre, zinc and magnesium may have a beneficial effect on alleviating inflammation in the body, reducing oxidative stress, and improving the condition of the intestinal microbiota through various epigenetic mechanisms. Moreover, epigenetics involves alterations in the phenotype of a cell without changing its fundamental DNA sequence. It appears that the modulation of the microbiota by various nutrients may lead to epigenetic regulation. The correlations between microbiota and epigenetics are potentially interdependent. Therefore, the primary objective of this review is to identify the complex relationships between diet, gut microbiota, and epigenetic regulation. These interactions could play a crucial role in systemic health.

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“…This is also demonstrated in individuals with obesity or overweight where supplementation reduced fasting blood glucose, decreased truncal subcutaneous fat, and reversed to normoglycemia [ 232 ]. Gut microbiota, vitamin D, and the development of metabolic diseases, including T2DM [ 233 ], has been described as a three-way axis with vitamin D anti-inflammatory actions playing a central role. Particularly, vitamin D binding to the vitamin D receptor (VDR) influences gut microbial composition, with findings showing increased Bifidobacterium and Akkermansia species, which exert anti-inflammatory effects and improve insulin resistance [ 234 ].…”

Section: Effects Of Micronutrients On T2dm and Gut Microbiotamentioning

confidence: 99%

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Hamamah,

Iatcu,

Covasa

2024

Nutrients

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Nutrition is one of the most influential environmental factors in both taxonomical shifts in gut microbiota as well as in the development of type 2 diabetes mellitus (T2DM). Emerging evidence has shown that the effects of nutrition on both these parameters is not mutually exclusive and that changes in gut microbiota and related metabolites such as short-chain fatty acids (SCFAs) and branched-chain amino acids (BCAAs) may influence systemic inflammation and signaling pathways that contribute to pathophysiological processes associated with T2DM. With this background, our review highlights the effects of macronutrients, carbohydrates, proteins, and lipids, as well as micronutrients, vitamins, and minerals, on T2DM, specifically through their alterations in gut microbiota and the metabolites they produce. Additionally, we describe the influences of common food groups, which incorporate varying combinations of these macronutrients and micronutrients, on both microbiota and metabolic parameters in the context of diabetes mellitus. Overall, nutrition is one of the first line modifiable therapies in the management of T2DM and a better understanding of the mechanisms by which gut microbiota influence its pathophysiology provides opportunities for optimizing dietary interventions.

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Vitamin D, Gut Microbiota, and Cardiometabolic Diseases—A Possible Three-Way Axis

Cited by 15 publications

References 77 publications

Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease

Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease

Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

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