Vitamin D level in pregnant women with preeclampsia

Шелепова, Е. С.; Яковлева, Н. Ю.; Рябоконь, Н. Р.; Кузнецова, Л. В.; Хаджиева, Э Д; Зазерская, И. Е.

doi:10.18705/1607-419x-2015-21-6-623-629

Cited by 6 publications

(1 citation statement)

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“…Vitamin D deficiency is a notable risk factor for preeclampsia development, due to its regulation of the transcription and activity of genes associated with placental function, including placental invasion, normal implantation, and angiogenesis. 4,5 A metabolic intermediate of vitamin D, 25-hydroxyvitamin D (25[OH]D), plays a vital role in maintaining the balance of calcium and phosphate metabolism by promoting the absorption and utilization of calcium. 6 In its active form as 1, 25-dihydroxyvitamin D, it significantly inhibits vascular endothelial growth factor (VEGF)-induced endothelial cell activation and vascular formation.…”

Section: Introductionmentioning

confidence: 99%

Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia

Chen

Cui

et al. 2019

J Int Med Res

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Objective To determine the association between levels of serum 25-hydroxyvitamin D (25[OH]D) and soluble fms-like tyrosine kinase 1 (sFlt-1) in patients with preeclampsia. Methods Clinical and demographic data were collected from patients with preeclampsia and healthy pregnant controls. Serum 25(OH)D and sFlt-1 levels were evaluated by enzyme-linked immunosorbent assay and their correlations were determined using Spearman’s rank correlation coefficient. Associations between serum 25(OH)D and sFlt-1 levels and disease severity and clinical parameters were evaluated. Results Significantly lower serum 25(OH)D and higher sFlt-1 levels were observed in patients with preeclampsia ( n = 100) versus controls ( n = 100), and 25(OH)D was inversely correlated with sFlt-1 in patients with preeclampsia. Serum 25(OH)D levels were reduced, while sFlt-1 concentration was increased in patients with severe versus mild preeclampsia. Serum 25(OH)D levels were reduced in late-onset versus early-onset severe preeclampsia. Patients with preeclampsia who had lower serum 25(OH)D or elevated sFlt-1 levels showed significantly higher blood pressure indexes versus those with higher 25(OH)D or lower sFlt-1. Conclusions Low serum 25(OH)D and high sFlt-1 may be candidate biomarkers for preeclampsia diagnosis and prognosis.

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Section: Introductionmentioning

confidence: 99%