Vitamin D, Parathyroid Hormone, and Serum Lipid Profiles in a Middle-Aged and Elderly Chinese Population

Chen, Wei Ren; Sha, Yuan; Chen, Yun Dai; Shi, Yang; Yin, Da Wei; Wang, Hao

doi:10.4158/ep13329.or

Cited by 8 publications

(8 citation statements)

References 35 publications

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“…Ponda et al reported that LDL-C was inversely correlated with serum PTH in a vitamin D repletion group ( 32 ). However, other studies found no association between serum cholesterol and bone turnover markers ( 12 , 30 , 31 , 33 ).…”

Section: Discussionmentioning

confidence: 84%

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Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes

et al. 2018

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Purpose: The association between bone mineral density (BMD), bone turnover markers, and serum cholesterol in healthy population has already been proved. However, in patients with type 2 diabetes mellitus (T2D), it has not been adequately analyzed. In this study, we investigated the correlation between BMD, bone turnover markers, and serum cholesterol levels in people with T2D.Methods: We enrolled 1,040 men and 735 women with T2D from Zhongshan Hospital between October 2009 and January 2013. Their general condition, history of diseases and medication, serum markers, and BMD data were collected. We used logistic regression analysis to identify the association between serum cholesterol levels and BMD as well as bone turnover markers.Results: In multivariate regression analysis, we observed that in men with T2D, high high-density lipoprotein-cholesterol and total cholesterol levels were significantly associated with low total lumbar, femur neck, and total hip BMD, while low-density lipoprotein-cholesterol level was only inversely associated with total lumbar and femur neck BMD. Total cholesterol and low-density lipoprotein-cholesterol levels were also negatively associated with osteocalcin, procollagen type I N-terminal propeptide, and β-crosslaps. In women with T2D, high-density lipoprotein-cholesterol level was observed to be negatively correlated with total lumbar, femur neck, and total hip BMD, while total cholesterol and low-density lipoprotein-cholesterol levels were only associated with BMD at the total lumbar. Furthermore, total cholesterol was also negatively associated with osteocalcin, procollagen type I N-terminal propeptide, and β-crosslaps; high-density lipoprotein-cholesterol was only related to osteocalcin and parathyroid hormone, while low-density lipoprotein-cholesterol was only related to β-crosslaps in women.Conclusion: Our study suggests a significantly negative correlation between serum cholesterol levels and BMD in both men and women with T2D. The associations between serum cholesterol levels and bone turnover markers were also observed in T2D patients.

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Section: Discussionmentioning

confidence: 84%

“…According to Ponda et al in vitamin D repletion group, LDL-C was inversely correlated with serum parathyroid hormone (PTH) ( 32 ). However, another study found no association between PTH and serum cholesterol ( 33 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes

et al. 2018

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“…Our results are mainly in line with previous crosssectional studies on the association between serum 25(OH)D and serum lipids. Few studies reported no significant association with any lipid at all (31,32) . By contrast, as in the total, unstratified sample in the present study, 25(OH)D levels in previous studies were found to be significantly positively associated with HDL-C (5,14,25,(28)(29)(30)33) and significantly inversely associated with TAG (5,14,25,29,30) in most studies.…”

Section: Discussionmentioning

confidence: 99%

“…The covariables were chosen based upon prior studies on the association between 25(OH)D and serum lipids (5,14,(25)(26)(27)(28)(29)(30)(31)(32)(33) . Information on age, sex, self-identified ethnicity, level of education, physical activity, smoking behaviour, alcohol consumption and intake of prescribed cholesterol-lowering medication was obtained from the interview.…”

Section: Covariable Assessmentmentioning

confidence: 99%

Effect of waist circumference on the association between serum 25-hydroxyvitamin D and serum lipids: results from the National Health and Nutrition Examination Survey 2001–2006

Vogt¹,

Baumert²,

Peters³

et al. 2016

Public Health Nutr.

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“…In the majority of previous studies, the focus was on the associations between serum vitamins and serum lipids in specific populations (e.g., obese people [10], cardiovascular disease patients [11], and diabetics [12]). Furthermore, most studies involving Chinese subjects focused on the association between a single vitamin, especially vitamin D, and serum lipids [13,14]. However, the associations between other serum vitamins and lipid profiles have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Associations between serum vitamins and serum lipids in healthy Northeast China adults

Li¹,

Xia

et al. 2019

Preprint

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Objective In previous studies, serum vitamins were shown associated with lipid levels. However, evidence regarding the associations between various serum vitamins and serum lipids is limited. Therefore, the associations between serum vitamins and serum lipids were investigated in this cross-sectional study.Methods The study population included 131 adults (42 males and 89 females) ≥ 18 years of age who lived more than three years in Shenyang, Liaoning province, China. Serum lipids included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Analysis of covariance was used to explore the associations between serum vitamins and serum lipids.Results After multiple adjustments, vitamin A and vitamin C concentrations were positively associated with LDL-C level ( P for trend < 0.05). Vitamin A, vitamin B5, and vitamin C concentrations were positively associated with TG level ( P for trend < 0.05). However, vitamin B1 concentration was negatively associated with TG level ( P for trend = 0.04). Vitamin E concentration was positively associated with HDL-C level ( P for trend = 0.02). No association was observed between vitamin concentrations and TC level.Conclusion The results in the present study indicate that serum vitamin concentrations are associated with serum lipid levels. Vitamin B1 and vitamin E concentrations were associated with a better status of lipid profiles. However, vitamin A, vitamin C, and vitamin B5 concentrations were associated with a worse status of lipid profiles.

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Vitamin D, Parathyroid Hormone, and Serum Lipid Profiles in a Middle-Aged and Elderly Chinese Population

Cited by 8 publications

References 35 publications

Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes

Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes

Effect of waist circumference on the association between serum 25-hydroxyvitamin D and serum lipids: results from the National Health and Nutrition Examination Survey 2001–2006

Associations between serum vitamins and serum lipids in healthy Northeast China adults

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